10515-5

Thyroglobulin Ag [Presence] in Tissue by Immune stain

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Part Descriptions

LP14697-4   Thyroglobulin
Thyroglobulin (Tg) is a protein produced by and used entirely within the thyroid gland. Thyroglobulin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is stored in the thyroid in follicle cysts surrounded by colloid cells. Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Thyroxine is produced by linking two moieties of DIT. Combining one particle of MIT and one particle of DIT produces triiodothyronine. Proteases in lysosomes digest iodinated thyroglobulin, releasing T3 and T4. Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin levels in the blood can also be elevated in cases of Graves Disease. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Thyroglobulin (Wikipedia)

LP14697-4   Thyroglobulin
Thyroglobulin (Tg) is a glycoprotein homodimer produced by the thyroid gland. It is important in the synthesis of thyroxine and triiodothyronine, and is where the inactive forms of thyroid hormone and iodine are stored. Mutations in the Tg gene cause thyroid dyshormonogenesis resulting in goiter, and can be associated with moderate to severe congenital hypothyroidism. Polymorphisms in the Tg gene are associated with susceptibility to autoimmune thyroid diseases such as Graves disease or Hashimoto thyroiditis. [NCBI Gene ID:7038] Tg is an established tumor marker used in the diagnosis of differentiated thyroid carcinoma. PMID: 9543128 Source: Regenstrief LOINC

Fully-Specified Name

Component

Thyroglobulin Ag

Property

PrThr

Time

Pt

System

Tiss

Scale

Ord

Method

Immune stain

Additional Names

Short Name

Thyroglob Ag Tiss Ql ImStn

Display Name

Thyroglobulin Ag Immune stain Ql (Tiss)

Consumer Name Alpha Get Info

Thyroglobulin antigen, Tissue

Basic Attributes

Class

PATH

Type

Laboratory

First Released

Version 1.0i

Last Updated

Version 2.73

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

10276

Language Variants Get Info

Related Names

• Antigen
• Antigens
• IHC
• Imm
• Immunohistochemical stain
• Immunostain
• ImStn
• Imun
• Imune
• Ordinal
• PATHOLOGY
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• St
• Stains
• Stn
• Tg
• Thyglobulin
• Thyroglbn
• Thyroglob
• Tissue
• Tissue, unspecified
• Tumor marker

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=10515-5

LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.