1096-7
K Ag [Presence] on Red Blood Cells
Active
Part Description
LP14926-7 K
Kell is highly polymorphic. It has two major codominant alleles, k and K, which result from a SNP (698C→T), and the corresponding k and K antigens differ by a single amino acid change (T193M). Mostly IgG antibodies, so IgM is uncommon. Anti-K does not bind complement. If hemolysis does occur, it is extravascular in nature. Anti-K can cause a severe hemolytic transfusion reaction and severe fetal anemia. In the RBC membrane, the Kell glycoprotein is covalently linked to the XK protein, a multipass membrane protein thought to have a role in transport. In the absence of XK, a condition called McLeod syndrome, Kell antigens are only weakly expressed and the RBCs are abnormal with spiky projections (acanthocytosis). Systemic findings include muscular dystrophy, cardiomyopathy, psychiatric disturbances, and neurological defects, such as loss of reflexes and movement disorders. The frequency of K antigens is 2% in Blacks, 9% in Caucasians, up to 25% in Arabs populations. Beck L, Blood groups and red cell antigens. NCBI Bookself [Internet Book], 2005.
Source: National Library of Medicine, K
Fully-Specified Name
- Component
- K Ag
- Property
- PrThr
- Time
- Pt
- System
- RBC
- Scale
- Ord
- Method
Additional Names
- Short Name
- K Ag RBC Ql
- Display Name
- K Ag Ql (RBC)
- Consumer Name Alpha Get Info
- K antigen, Red blood cells
Basic Attributes
- Class
- BLDBK
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 7405
Member of these Panels
LOINC | Long Common Name |
---|---|
93914-0 | Blood group antigens panel - Red Blood Cells |
93951-2 | Rh antigens and K Ag panel - Blood |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-AR | Spanish (Argentina) | [antígeno-] K [Ag]: |
es-ES | Spanish (Spain) | K Antígeno: |
es-MX | Spanish (Mexico) | K Ag: |
et-EE | Estonian (Estonia) | K antigeen: Synonyms: Erütrotsüüdid Järgarvuline Juhuslik |
fr-CA | French (Canada) | K, Ag: |
fr-FR | French (France) | KEL1 (K) antigène: |
fr-BE | French (Belgium) | K Ag: Synonyms: Antigène |
it-IT | Italian (Italy) | K, Ag: Synonyms: Banca del sangue Globuli rossi Presenza o Soglia Punto nel tempo (episodio) |
ko-KR | Korean (Korea, Republic Of) | k 항원: |
nl-NL | Dutch (Netherlands) | K Ag: Synonyms: antigeen rode bloedcellen |
pt-BR | Portuguese (Brazil) | K Ag: Synonyms: Arbitrary concentration; |
ru-RU | Russian (Russian Federation) | K Аг: Synonyms: Порядковый Точка во времени; |
tr-TR | Turkish (Turkey) | K Ag: Synonyms: Antijen Mevcut RBC |
zh-CN | Chinese (China) | K 抗原: Synonyms: Ag K 型 K 抗原 RBC; |
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