Version 2.77

Part Descriptions

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, D-lactate (Wikipedia)

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. PMID: 3882046. Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition] Source: Regenstrief LOINC

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. Lactate Dehydrogenase (LD)

Fully-Specified Name

Lactate dehydrogenase
Reaction: lactate to pyruvate

Additional Names

Short Name
LDH SerPl L to P-cCnc
Display Name
LDH Lactate to pyruvate reaction [Catalytic activity/Vol]
Consumer Name Alpha Get Info
Lactate Dehydrogenase (LDH), Blood

Associated Observations

95405-7 Assay related variables panel [PhenX]

This panel contains a collection of ask-at-order entry questions and associated observations that may be included within various PhenX protocols for biomarker testing. Each protocol varies as to the items asked & recorded, so not all terms will be used but are displayed together for users to find the appropriate LOINCs.

LOINC Name R/O/C Cardinality Example UCUM Units
95405-7 Assay related variables panel
Indent30525-0 Age a
Indent46098-0 Sex
Indent66165-2 Last ate or drank anything other than plain water [Date and time]
Indent80331-2 Date and time of last void {clock_time}
Indent66177-7 Do you have hemophilia?
Indent94741-6 Cancer chemotherapy received in the past 4W
Indent66178-5 Have you received cancer chemotherapy in the past four weeks or do you anticipate such therapy in the next four weeks?
Indent66504-2 Exclusion Criteria
Indent41395-5 Collection date of Urine
Indent74751-9 Collection time of Urine {clock_time}
Indent94331-6 Specimen Collection procedure comment
Indent95044-4 Patient refused specimen collection
Indent94846-3 History of Specimen collection problem
Indent94847-1 Reason specimen not collected
Indent77301-0 Reason care action performed or not
Indent66180-1 Was blood drawn?
Indent66181-9 Was full sample obtained?
Indent94330-8 Specimen Processing comment
Indent8251-1 Service comment
Indent85069-3 Lab test method [Type]
Indent66200-7 Repeatability of the assay {ratio}
Indent66201-5 Coefficient of variation for the assay {CV}
Indent66208-0 Make of the equipment used to perform...
Indent74719-6 Manufacturer of the equipment used
Indent74720-4 Device name

Basic Attributes

First Released
Version 1.0k
Last Updated
Version 2.73
Order vs. Observation
Common Test Rank Get Info

Member of these Panels

LOINC Long Common Name
42929-0 Lactate dehydrogenase panel - Serum or Plasma

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Lactatdehydrogenase:Katalytische Konzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:Reaktion: Lactat zu Pyruvat
Synonyms: LDH
de-AT German (Austria) Synonyms: LDH
es-AR Spanish (Argentina) lactato deshidrogenasa:concentración catalítica:punto en el tiempo:suero/plasma:cuantitativo:reacción: lactato a piruvato
es-ES Spanish (Spain) Lactato deshidrogenasa:Concentración Catalítica:Punto temporal:Suero o Plasma:Qn:Reacción - lactato piruvato
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Lactato deshidrogenasa:Concentración catalítica:Punto temporal:Suero o Plasma:Cuantitativo:Reacción - lactato a piruvato
fr-CA French (Canada) Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:Réaction: lactate en pyruvate
fr-FR French (France) Lactate déhydrogénase:Catalytique/Volume:Ponctuel:Sérum/Plasma:Numérique:Réaction : Lactate vers Pyruvate
fr-BE French (Belgium) Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:Réaction: lactate en pyruvate
Synonyms: LDH
it-IT Italian (Italy) Lattato deidrogenasi:CCnC:Pt:Siero/Plasma:Qn:Reazione: lattato in piruvato
Synonyms: Chimica Concentrazione Catalitica Plasma Punto nel tempo (episodio) Reazione- lattato in piruvato Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 젖산 탈수소효소:촉매농도:검사시점:혈청/혈장:정량 :반응:젖산에서에서 피루브산염 반응:
nl-NL Dutch (Netherlands) lactaatdehydrogenase:enzymatische activiteit/volume:moment:serum of plasma:kwantitatief:reactie: lactaat naar pyruvaat
pl-PL Polish (Poland) Dehydrogenaza mleczanowa:stężenie katalityczne:punkt w czasie:surowica lub osocze:ilościowy:reakcja L-P, mleczan-pirogronian
pt-BR Portuguese (Brazil) Desidrogenase Láctica:CCnc:Pt:Sor/Plas:Qn:Reação de lactato a piruvato
Synonyms: ; LDH; L.D.H; Lactic acid dehydrogenase; LD; L-lactate dehydrogenase; Lact; 2-hydroxy-propionic acid; 2-hydroxy-propionate; Catalytic Concentration; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; L to P; Rxn; React; Dehydrog; Dehyrdogenase; Chemistry
tr-TR Turkish (Turkey) Laktat dehidrojenaz:KtlKons:Zmlı:Ser/Plaz:Kant:Reaksiyon: laktat tan piruvat a
uk-UA Ukrainian (Ukraine) Лактатдегідрогеназа:Каталітична Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:Реакція - лактат до піруват
Synonyms: 2-Hydroxypropanoic acid; 2-hydroxy-propionate; 2-hydroxy-propionic acid; Catalytic Concentration; Chemistry; Dehydrog; Dehyrdogenase; L to P; L.D.H; Lact; Lactic acid; Lactic acid dehydrogenase; LD; LDH; L-lactate; L-lactate dehydrogenase; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; React; Rxn; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; Tumor marker; UniversalLabOrders
zh-CN Chinese (China) 乳酸脱氢酶:催化浓度:时间点:血清/血浆:定量型:反应: 乳酸至丙酮酸
Synonyms: 2-羟基-丙酸;Lact;L-乳酸 L.D.H;LD;LDH;L-乳酸脱氢酶 React Rxn 乳酸 - 丙酮酸转化法;乳酸 -> 丙酮酸转化法;乳酸转化为丙酮酸的反应;反应: 乳酸 - 丙酮酸;反应: 乳酸 -> 丙酮酸 催化浓度(单位体积);单位体积内酶的单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 去氢酶 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清或血浆

Example Units

Unit Source
U/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup$lookup?system=