LOINC
Version 2.70

1743-4Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma by With P-5'-PActive

Term Description

Alanine aminotransferase (ALT) is an enzyme found primarily in the cells of the liver and is used to monitor possible liver damage. The ALT can be elevated from a number of causes including viral Hepatitis A or B, severe liver damage resulting from toxins in the blood such as medication overdose, and extended collapse of the circulatory system. P-5-P, also known as vitamin B6, is a co-enzyme to ALT during amino group transfer. When the assay for ALT is run, it is recommended by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) that P-5-P be added to the reaction to ascertain that all of the ALT enzyme activity is measured. If the patient is deficient in B6 and additional P-5-P were not added, a falsely low level of ALT enzyme activity could be reported. Information from www.aacb.asn.au, MedicineNet.com, www.iffc.org accessed 2008 08 20.
Source: Regenstrief Institute

Part Descriptions

LP15333-5   Alanine aminotransferase
Alanine transaminase or ALT is an enzyme (EC 2.6.1.2) also called serum glutamic pyruvic transaminase (SGPT) or alanine aminotransferase (ALAT). It is found in serum and in various bodily tissues, but is most commonly associated with the liver. It catalyzes the two parts of the alanine cycle. It is commonly measured clinically as a part of a diagnostic evaluation of liver health. Significantly elevated levels of ALT often suggest the existence of other medical problems such as viral hepatitis, diabetes, congestive heart failure, bile duct problems, infectious mononucleosis, or myopathy. However, elevated levels of ALT do not automatically mean that medical problems exist. Fluctuation of ALT levels is normal over the course of the day, and ALT levels can also increase in response to strenuous physical exercise. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, ALT

LP15333-5   Alanine aminotransferase
Alanine aminotransferase (ALT) is an enzyme produced primarily in the liver but are also found in the heart, skeletal muscles, pancreas and kidney cells. The main function of ALT is to convert alanine into pyruvate. ALT is released into the bloodstream when cells containing it are damaged. Increased levels of ALT in the blood provide an early indicator of liver damage. ALT is often measured with aspartate aminotransferase (AST) as part of a liver panel. High levels of ALT could indicate hepatitis, obstructed bile ducts, liver tumors, cirrhosis, alcoholism or other liver disorders. [Lab Tests Online:alt/tab/sample] Source: Regenstrief LOINC

LP6762-1   With P-5'-P
Pyridoxal phosphate is a derivative of Vitamin B6 and is used by enzymes in all organisms. The majority of enzymes which depend on pyridoxal phosphate are associated with pathways involving amino acids, such as amino group transfer, decarboxylation and other important biochemical processes. [PMCID: 1326353]
When measuring AST and/or ALT without pyridoxal-5-phosphate (P-5-P), the rate of the decrease of NADH is directly proportional to the AST/ALT (respectively)-activity in the specimen. Testing for AST and/or ALT with the addition of P-5-P stabilizes the transaminases in the specimen and avoids falsely low values in specimens of patients suffering from either myocardial infarction or liver disease, who have an insufficient amount of P-5-P in their blood. Source: Regenstrief LOINC

Fully-Specified Name

Component
Alanine aminotransferase
Property
CCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
With P-5'-P

Additional Names

Short Name
ALT SerPl w P-5'-P-cCnc
Display Name
ALT With P-5'-P [Catalytic activity/Vol]
Consumer Name Alpha
Alanine Aminotransferase (ALT; SGPT), Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.68
Order vs. Observation
Both

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2001-2019 American Association for Clinical Chemistry Alanine Aminotransferase (ALT)

Member of these Panels

LOINC Long Common Name
48796-7 Hepatitis C virus FibroSURE panel - Serum or Plasma
93691-4 Nonalcoholic steatohepatitis and fibrosis panel - Serum or Plasma

Member of these Groups

LG5272-2 Alanine aminotransferase|CCnc|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
丙氨酸氨基转移酶:催化浓度:时间点:血清/血浆:定量型:采用 P-5'-P
nl-NLDutch (Netherlands)
alanine-aminotransferase:enzymatische activiteit/volume:moment:serum of plasma:kwantitatief:met P-5'-P
et-EEEstonian (Estonia)
Alaniini aminotransferaas:CCnc:Pt:S/P:Qn:P-5''-P-ga
fr-BEFrench (Belgium)
Alanine aminotransférase, Transaminase GP:Concentration catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:avec P-5'-P
fr-CAFrench (Canada)
Alanine aminotransférase:Concentration catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:avec P-5'-P
fr-FRFrench (France)
Alanine aminotransférase:Catalytique/Volume:Ponctuel:Sérum/Plasma:Numérique:Avec phosphate de pyridoxal
de-DEGerman (Germany)
Alanin-Aminotransferase:KKnz:Pkt:Ser/Plas:Qn:Mit P-5'-P
it-ITItalian (Italy)
Alanina aminotransferasi:CCnC:Pt:Siero/Plasma:Qn:Con P-5'-P
ko-KRKorean (Korea, Republic of)
알라닌 아미노전이효소:촉매농도:검사시점:혈청/혈장:정량:With P-5'-P
pt-BRPortuguese (Brazil)
Alanina aminotransferase:CCnc:Pt:Sor/Plas:Qn:Com P-5'-P
es-ARSpanish (Argentina)
con P-5'-P:concentración catalítica:punto en el tiempo:suero/plasma:cuantitativo:WITH P-5'-P
es-ESSpanish (Spain)
Alanina aminotransferasa:Concentración Catalítica:Punto temporal:Suero o Plasma:Qn:Con piridoxal-5-fosfato
tr-TRTurkish (Turkey)
Alanin aminotransferaz:KtlKons:Zmlı:Ser/Plaz:Kant:P-5'-P ile

Example Units

Unit Source
U/L eCHN
U/L Example UCUM Units
units/L REGENSTRIEF

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