31447-6
Deprecated Jo-1 extractable nuclear Ab [Units/volume] in Serum
Deprecated
Status Information
- Status
- DEPRECATED
- Reason
- Duplicate
Map-To | Long Common Name | Mapping Guidance |
---|---|---|
11565-9 | Jo-1 extractable nuclear Ab [Units/volume] in Serum |
Part Description
LP16719-4 Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes.
Source: Regenstrief LOINC, PMID: 23573256
Fully-Specified Name
- Component
- Jo-1 extractable nuclear Ab
- Property
- ACnc
- Time
- Pt
- System
- Ser
- Scale
- Qn
- Method
Additional Names
- Short Name
- Deprecated ENA Jo1 Ab Ser-aCnc
- Display Name
- Jo-1 extractable nuclear Ab Qn (S)
- Consumer Name Alpha Get Info
- Jo-1 extractable nuclear antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.07
- Last Updated
- Version 2.69
Member of these Groups Get Info
LOINC Group | Group Name |
---|---|
LG352-1 | Jo-1 extractable nuclear Ab| |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-AR | Spanish (Argentina) | [anticuerpo] antinuclear extraíble JO-1 [Ac]: |
es-ES | Spanish (Spain) | Jo-1 Anticuerpos: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Ab nuclear extraíble Jo-1: |
fr-CA | French (Canada) | Jo-1 nucléaire soluble, Ac: |
fr-BE | French (Belgium) | Jo-1 nucléaire soluble Ac: Synonyms: Anticorps |
it-IT | Italian (Italy) | Jo-1, nucleare estraibile Ab: Synonyms: anticorpo Concentrazione Arbitraria ENA Jo1 Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
nl-NL | Dutch (Netherlands) | jo-1 extraheerbaar nucleair As: Synonyms: antistof; |
pl-PL | Polish (Poland) | Jo-1 rozpuszczalny jądrowy Ab: Synonyms: Jo-1 rozpuszczalny jądrowy Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała do rozpuszczalnego jądrowego antygenu Jo-1 Przeciwciała przeciwjądrowe |
pt-BR | Portuguese (Brazil) | Jo-1 Ac: Synonyms: ; |
ru-RU | Russian (Russian Federation) | Jo-1 экстрагируемый ядерный Ат: Synonyms: Антитело Количественный Произвольная концентрация Сыворотка Точка во времени; |
tr-TR | Turkish (Turkey) | Jo-1 öztlenebilir çekirdek Ab: Synonyms: Ak Çekirdek |
zh-CN | Chinese (China) | Jo-1 可提取性核 抗体: Synonyms: Ⅰ Ab; |
Example Units
Unit | Source |
---|---|
[arb'U]/mL | Example UCUM Units |
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