34972-0
DNA index 3 in Specimen by Flow cytometry (FC)
Active
Term Description
DNA Index 3rd peak
Source: Regenstrief LOINC
Part Descriptions
LP33218-6 DNA index 3
DNA index (DI), which is associated with DNA ploidy, is a reflection of the average amount of DNA in the tumor cells. The DI can be measured by flow cytometry or image cytometry, both of which result in a DNA ploidy histogram, where the channel number on the x-axis represents fluorescent intensity or optical density for the two methods, respectively. All cells with the same quantity of DNA form one peak on the histogram, and with a population of normal cells, the largest peak represents diploid cells in G1 of the cell cycle, and a smaller peak represents cells in G2/M-phase. When there is a mixed population of normal and tumor cells, two or more G1 peaks will be seen, one for the normal cells and one or more for the tumor cells. The DI is calculated by dividing the channel number of the tumor cell G1 peak by the channel number of the normal (diploid control) G1 peak. If the tumor cells are diploid, the DI is 1, and if the cells are aneuploid, the DI is greater than or less than 1. For example, tetraploid cells have a DI of 2 because they have twice as much DNA content as normal diploid cells, and hypodiploid tumor cells have a DI of <1. PMID: 24532190
Source: Regenstrief LOINC, PMID: 24532190
LP33218-6 DNA index 3
The third DNA index peak
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- DNA index 3
- Property
- ACnc
- Time
- Pt
- System
- XXX
- Scale
- Qn
- Method
- Flow cytometry
Additional Names
- Short Name
- DNA Index 3 Spec FC-aCnc
- Display Name
- DNA index 3 FC Qn (Specimen)
- Consumer Name Alpha Get Info
- DNA index 3, Specimen
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.11
- Last Updated
- Version 2.69
- Order vs. Observation
- Observation
Formula (Readable)
DNA index (DI) = mean channel # of the G1 peak of the tumor/mean channel # of G1 peak of normal cells
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-AR | Spanish (Argentina) | índice de ADN 3: |
es-ES | Spanish (Spain) | Indice ADN 3: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Índice de ADN 3: |
fr-FR | French (France) | ADN index 3: |
it-IT | Italian (Italy) | DNA, indice 3: Synonyms: Citometria a flusso (FC) Concentrazione Arbitraria Indice di DNA Indice di DNA 3 Patologia molecolare Punto nel tempo (episodio) |
ko-KR | Korean (Korea, Republic Of) | 디옥시리보핵산 지수 3: |
nl-NL | Dutch (Netherlands) | DNA index 3: |
pt-BR | Portuguese (Brazil) | DNA índice 3: Synonyms: DNA Index 3rd peak; |
ru-RU | Russian (Russian Federation) | DNA индекс 3: Synonyms: ДНК отношение Количественный Произвольная концентрация Точка во времени; |
tr-TR | Turkish (Turkey) | DNA indeksi 3: Synonyms: Akış hücremetresi |
zh-CN | Chinese (China) | DNA 指数 3: Synonyms: Ⅲ DI; |
Example Units
Unit | Source |
---|---|
[arb'U]/mL | Example UCUM Units |
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