Version 2.78

Part Description

LP15841-7   Purine nucleoside phosphorylase
Purine nucleoside phosphorylase (also known as PNPase) is an enzyme (EC 2.4.2.1) involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine, in each case creating ribose phosphate. NP encodes the enzyme purine nucleoside phosphorylase that, together with adenosine deaminase (ADA), serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in ADA lead to an accumulation of (d)ATP, which inhibits ribonucleotide reductase, leading to a deficiency in (d)CTPs and (d)TTPs, which, in turn, induces apoptosis in T-lymphocytes and B-lymphocytes, leading to severe combined immunodeficiency (SCID).

PNP-deficient patients will have an immunodeficiency problem. It affects only T-cells; B-cells are unaffected by the deficiency. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Purine nucleoside phosphorylase
Property
CCnc
Time
Pt
System
CSF
Scale
Qn
Method

Additional Names

Short Name
PNP CSF-cCnc
Display Name
Purine nucleoside phosphorylase (CSF) [Catalytic activity/Vol]
Consumer Name Alpha Get Info
Purine nucleoside phosphorylase, Spinal fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.11
Last Updated
Version 2.68
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) purina nucleósido fosforilasa:concentración catalítica:punto en el tiempo:líquido cefalorraquídeo:cuantitativo:
es-ES Spanish (Spain) Purin nucleósido fosforilasa:Concentración Catalítica:Punto temporal:Líquido Cefalorraquideo:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Purina nucleósido fosforilasa:Concentración catalítica:Punto temporal:Fluído espinal cerebral:Cuantitativo:
et-EE Estonian (Estonia) Puriini nukleosiidi fosforülaas:CCnc:Pt:CSF:Qn:
Synonyms: Juhuslik Kvantitatiivne Liikvor
fr-CA French (Canada) Purine-nucléoside phosphorylase:Concentration catalytique:Temps ponctuel:LCR:Quantitatif:
fr-FR French (France) Purine nucléoside phosphorylase:Catalytique/Volume:Ponctuel:Liquide céphalorachidien:Numérique:
fr-BE French (Belgium) Purine-nucléoside phosphorylase:Concentration catalytique:Temps ponctuel:LCR:Quantitatif:
it-IT Italian (Italy) Purina nucleoside fosforilasi:CCnC:Pt:LCS:Qn:
Synonyms: Chimica Concentrazione Catalitica Liquido cerebrospinale PNPasi Punto nel tempo (episodio)
ko-KR Korean (Korea, Republic Of) 퓨린 뉴클레오시드 포스포릴라아제:촉매농도:검사시점:뇌척수액:정량:
nl-NL Dutch (Netherlands) purinenucleosidefosforylase:enzymatische activiteit/volume:moment:liquor cerebrospinalis:kwantitatief:
pl-PL Polish (Poland) Fosforylaza nukleozydów purynowych:stężenie katalityczne:punkt w czasie:płyn mózgowo-rdzeniowy:ilościowy:
pt-BR Portuguese (Brazil) Purina nucleosídeo fosforilase:CCnc:Pt:LCR:Qn:
Synonyms: ; PNP; Catalytic Concentration; Point in time; Random; Cerebral spinal fluid; Spinal Fluid; Cerebrospinal Fl; Spinal Flu; Spinal Fld; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU Russian (Russian Federation) Пуриновых нуклеозидов фосфорилаза:КаталКонц:ТчкВрм:ЦСЖ:Колич:
Synonyms: Каталитическая концентрация Количественный Точка во времени;Момент Цереброспинальная жидкость
tr-TR Turkish (Turkey) Pürin nukleozid fosforilaz:KtlKons:Zmlı:BOS:Kant:
zh-CN Chinese (China) 嘌呤核苷酸磷酸化酶:催化浓度:时间点:脑脊液:定量型:
Synonyms: CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 PNP 催化浓度(单位体积);单位体积内酶的单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 四氮杂茚 时刻;随机;随意;瞬间 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液

Example Units

Unit Source
U/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=35141-1