40636-3
Kappa light chains [Presence] in Urine by Immunofixation
Active
Part Descriptions
LP15030-7 Immunoglobulin light chains.kappa
All immunoglobulins contain two polypeptide chains: a long (heavy) and a short (light) chain. The two chains interact via disulfide bonds. There are two types of light chains, named kappa and lambda. Serum free light chain (SFLC) testing, a kappa/lambda ratio and a protein electrophoresis test are done to help detect, diagnose and monitor plasma cell disorders (dyscrasias) including multiple myeloma and primary amyloidosis. Normal readings are seen when there is a kappa/lambda ratio of approximately 0.26 to 1.65 and free light chains are present in the blood at low levels. Increased kappa free light chains and an increased kappa/lambda ratio are present with plasma cell disorders that produce excess monoclonal kappa light chains. The tests can also be used to monitor response to treatment. An increase in serum free light chains along with an abnormal kappa/lambda ratio may indicate primary amyloidosis; biopsy of affected tissue is typically used for confirmation of diagnosis. PMID: 6802926 ] [Lab Tests Online:free-light/tab/test]
Source: Regenstrief LOINC
LP6336-4 Immunofixation
Plasma or concentrated urine is deposited on a gel. With an electrical current the proteins are sorted in function of their size, after which antigens for each targeted type of immunoglobulin are deposited on the gel. Thus more or less narrow bands appear on the gel, marking the location of the various immunoglobulines.
Immunofixation tends to replace protein electrophoresis because:
• it is faster (results within three hours);
• it is somewhat more sensitive. Immunofixation may reveal an immunoglobulin missed out by protein electrophoresis, especially at low concentrations (less than 1 gram/litre);
• it can be partially automated and can be used in more laboratories;
• it is more easily read and interpreted.
Immunofixation is however only sensitive to immunoglobulins and is more expensive than protein electrophoresis.
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Source: Wikipedia, Immunofixation
Fully-Specified Name
- Component
- Immunoglobulin light chains.kappa
- Property
- PrThr
- Time
- Pt
- System
- Urine
- Scale
- Ord
- Method
- Immunofixation
Additional Names
- Short Name
- Kappa LC Ur Ql IFE
- Display Name
- Immunoglobulin light chains.kappa Immunofixation Ql (U)
- Consumer Name Alpha Get Info
- Immunoglobulin light chains.kappa, Urine
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.15
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016. Changed the LCN from 'Immunoglobulin light chains.kappa' to ' Kappa light chains' for readability.
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 19022
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG16697-1 | Immunoglobulin light chains.kappa| |
| LG36220-8 | Immunoglobulin light chains.kappa| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Immunglobulin Leichtketten.kappa: |
| es-ES | Spanish (Spain) | Cadenas ligeras de las inmunoglobulinas.kappa: |
| es-MX | Spanish (Mexico) | Cadenas ligeras de inmunoglobulina kappa: |
| et-EE | Estonian (Estonia) | Immuunoglobuliini kerged ahelad.kapa: Synonyms: Immuunglobuliinide kerged kapaahelad Järgarvuline Juhuslik Uriin |
| fr-CA | French (Canada) | Chaînes légères d'immunoglobulines.kappa: |
| fr-FR | French (France) | Immunoglobuline chaines légères kappa: |
| fr-BE | French (Belgium) | Chaînes légères immunoglobulines.kappa: Synonyms: LC LC. Kappa |
| it-IT | Italian (Italy) | Immunoglobuline, catene leggere.kappa: Synonyms: Catene leggere delle immunoglobuline Catene leggere kappa delle immunoglobuline Chimica Presenza o Soglia Punto nel tempo (episodio) |
| ko-KR | Korean (Korea, Republic Of) | 카파면역글로불린 경쇄: |
| nl-NL | Dutch (Netherlands) | immunoglobuline lichte ketens.kappa: |
| pl-PL | Polish (Poland) | Łańcuchy lekkie immunoglobuliny.kappa: Synonyms: Łańcuchy lekkie immunoglobulin Łańcuchy lekkie kappa immunoglobuliny |
| pt-BR | Portuguese (Brazil) | Imunoglobulinas cadeias leves.kappa: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Иммуноглобулин легкие цепи.каппа: Synonyms: Порядковый Точка во времени; |
| tr-TR | Turkish (Turkey) | İmmünglobulin hafif zincirler.kappa: Synonyms: Mevcut |
| zh-CN | Chinese (China) | 免疫球蛋白轻链.Kappa 型: Synonyms: Bence Jones 氏蛋白; |
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