41027-4
Tau protein/Amyloid beta 42 peptide [Ratio] in Cerebrospinal Fluid
Active
Part Descriptions
LP28537-6 Tau protein
CSF tau phosphorylated at threonine 181 (p-tau181) is a widely used biomarker for Alzheimer disease (AD) and has recently been regarded to reflect β-amyloid and/or p-tau deposition in the AD brain. Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease characterized by intranuclear inclusions in neurons, glial cells, and other somatic cells. Symptoms include dementia, neuropathy, and others. CSF biomarkers were not reported. The objective of this study was to investigate whether CSF biomarkers including p-tau181 are altered in patients with NIID.
Source: Máxima MC,
LP28537-6 Tau protein
Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.
Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability: isoforms and phosphorylation.
Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. The isoforms are a result of alternative splicing in exons 2,3, and 10 of the tau gene.
Phosphorylation of tau is regulated by a host of kinases. For example, PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization Taniguchi et al., 2001.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia,
Tau protein
LOINC Names Get Info
- Fully-Specified Name
- Tau protein/Amyloid beta 42 peptide:
Ratio: Pt: CSF: Qn: - Long Common Name
- Tau protein/Amyloid beta 42 peptide [Ratio] in Cerebrospinal Fluid
- Short Name
- Tau Prot/AL beta42 CSF-Rto
- Display Name
- Tau protein/Amyloid beta 42 peptide (CSF) [Ratio]
- Consumer Name Alpha Get Info
- Tau protein/Amyloid Beta 42 Peptide, Spinal fluid
Part Model Get Info
- Component
- Tau protein/Amyloid beta 42 peptide
LP287189-7
- Analyte
- Tau protein/Amyloid beta 42 peptide
LP287189-7
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- Ratio
LP6852-0
- Time
- Pt
LP6960-1
- Time Core
- Pt
LP6960-1
- Time Modifier
- NULL
- System
- CSF
LP7156-5
- System Core
- CSF
LP7156-5
- Super System
- NULL
- Scale
- Qn
LP7753-9
- Method
- NULL
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.15
- Last Updated
- Version 2.83 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 14186
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 104134-2 | Dementia evaluation panel - Cerebrospinal Fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Tau protein/amyloid beta 42 peptid: |
| de-AT | German (Austria) | Synonyms: Tau/Amyloid Beta 42 Ratio /Liquor |
| el-GR | Greek (Greece) | Πρωτεΐνη Tau/β-αμυλοειδές πεπτίδιο 42: Synonyms: CHEM Pt Qn Ratio β-αμυλοειδές πεπτίδιο 42 ΕΝΥ Πρωτεΐνη Πρωτεΐνη Tau |
| es-ES | Spanish (Spain) | Proteína Tau/Péptido beta amiloide 42: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Proteína tau / péptido beta amiloide 42: |
| fr-CA | French (Canada) | Protéine Tau/Peptide amyloïde bêta 42: |
| fr-FR | French (France) | Protéines Tau/peptide bêta amyloïde 1-42: |
| fr-BE | French (Belgium) | Protéine Tau/Peptide amyloïde béta 42: |
| it-IT | Italian (Italy) | Tau, proteina/Amiloide beta 42 peptide: Synonyms: Chimica Liquido cerebrospinale Proteina Tau Punto nel tempo (episodio) |
| ko-KR | Korean (Korea, Republic Of) | 타우 단백/아밀로이드 베타 42 펩티드: |
| nl-NL | Dutch (Netherlands) | tau-proteïne/amyloïd-bèta-42-peptide: Synonyms: amyloid beta 42 peptide |
| pl-PL | Polish (Poland) | Białko Tau/Β-amyloid 1-42: |
| pt-BR | Portuguese (Brazil) | Proteína tau/Beta amilóide peptídeo 42: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Тау протеин/Амилоид бета 42 пептид: Synonyms: Белок Количественный Коэффициент; |
| tr-TR | Turkish (Turkey) | Tau protein/Amiloid beta 42 peptid: |
| zh-CN | Chinese (China) | Tau 蛋白/淀粉样蛋白 Beta 42 肽: Synonyms: Ab42 peptide; |
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