43752-5

Aquaporin 4 water channel IgG Ab [Units/volume] in Serum or Plasma by Immunofluorescence

Active

Part Description

LP39188-5 Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome. PMID: 17706564 Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Aquaporin 4 water channel Ab.IgG:ACnc:Pt:Ser/Plas:Qn:IF
Long Common Name: Aquaporin 4 water channel IgG Ab [Units/volume] in Serum or Plasma by Immunofluorescence
Short Name: AQP4 H2O channel IgG SerPl IF-aCnc
Display Name: Aquaporin 4 water channel IgG IF Qn
Consumer Name Alpha Get Info: Aquaporin 4 water channel IgG antibody, Blood

Part Model Get Info

Component
Aquaporin 4 water channel Ab.IgG
LP39188-5
- Analyte
  Aquaporin 4 water channel Ab.IgG
  LP39188-5
  - Component Numerator
    Aquaporin 4 water channel Ab.IgG
    LP39188-5
    - Component Numerator Core
      Aquaporin 4 water channel
      LP102619-6
    - Component Numerator Core Suffix
      Ab.IgG
      LP32401-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IF
LP6323-2

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.17
Last Updated: Version 2.73 (MIN)
Change Reason: Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature
Order vs. Observation: Both
Common Test Rank Get Info: 18678

Member of these Groups Get Info

LOINC Group	Group Name
LG17454-6	Aquaporin 4 water channel Ab.IgG\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Akvaporin 4 IgG:Arbitrární koncentrace:Časový bod:Sérum/plazma:Kvantitativní:Imunofluoresecence (IF)
el-GR	Greek (Greece)	Δίαυλος ύδατος ακουαπορίνης 4 Αντισώματα IgG:ACnc:Pt:Ορός/Πλάσμα:Qn:Ανοσοφθορισμός Synonyms: ACnc Pt Qn SERO Ανοσοσφαιρίνη G Ανοσοφθορισμός Αντίσωμα Αντισώματα IgG Δίαυλος ύδατος ακουαπορίνης 4 Νερό Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	Receptor de Acuaporina 4 IgG:Concentración arbitraria:Punto temporal:Suero o Plasma:Qn:Inmunofluorescencia (IF) Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Acuaporina 4 canal de agua Ab.IgG:Concentración arbitraria:Punto temporal:Suero o Plasma:Cuantitativo:Inmunofluorescencia (IF)
et-EE	Estonian (Estonia)	Akvaporiin 4 retseptor antikehad.IgG:Acnc:Pt:S/P:Qn:IF Synonyms: Immuunglobuliin G Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA	French (Canada)	Canal de l'eau Aquaporin 4, IgG:Concentration arbitraire:Temps ponctuel:Sérum/Plasma:Quantitatif:Immunofluorescence
fr-FR	French (France)	Aquaporine 4 récepteur Ac IgG:Arbitraire/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunofluorescence
fr-BE	French (Belgium)	Récepteur Aquaporin 4 Anticorps. IgG:Concentration arbitraire:Temps ponctuel:Sérum/Plasma:Quantitatif:Immunofluorescence Synonyms: Anticorps
it-IT	Italian (Italy)	Acquaporina 4, canale idrico Ab.IgG:ACnc:Pt:Siero/Plasma:Qn:IF Synonyms: anticorpi IgG anticorpo Canale idrico dell''acquaporina 4 Concentrazione Arbitraria Immunofluorescenza (IF) Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	aquaporine 4 waterkanaal As.IgG:eenheid/volume:moment:serum of plasma:kwantitatief:immunofluorescentie Synonyms: antistof; antilichaam IF
pt-BR	Portuguese (Brazil)	Neuromyelitis optica Ac.IgG:ACnc:Pt:Sor/Plas:Qn:Imunofluorescência Synonyms: ; NMO; Devic's disease; Immune globulin G; Immunoglobulin G; Arbitrary concentration; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; ACIF; FA; Fluorescent antibody; Immune fluorescence; Fluoresent; Immunoflour; Immunofluor; Immunofluorescence; IFA; Time Resolved Fluorescence; Anticomplement Immunofluorescence; TRF; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU	Russian (Russian Federation)	Аквапорина 4 рецепторы Ат.IgG:ПроизвКонц:ТчкВрм:Сыв/Плаз:Колич:ИФ Synonyms: Антитело Иммунофлюоресценция (ИФ) Количественный Плазма Произвольная концентрация Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	Akuaporin 4 reseptörü Ab.IgG:SçKons:Zmlı:Ser/Plaz:Kant:IF Synonyms: Ak Ak.IgG İmmünflorerans
zh-CN	Chinese (China)	水通道蛋白 4 受体抗体.IgG:任意型浓度:时间点:血清/血浆:定量型:免疫荧光法 Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 Devic 氏综合征 IgG Devic 综合征 IgG Devic氏综合征 Ab.IgG Devic氏综合征抗体.IgG Devic综合征 Ab.IgG Devic综合征抗体.IgG H2O IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体 NMO Ab.IgG NMO 抗体.IgG 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度免疫球蛋白 G 可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类血清或血浆视神经脊髓炎 Ab.IgG 视神经脊髓炎 IgG

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

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Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.