Version 2.78

Part Description

LP72992-8   Nuclear pleomorphism
The degree of nuclear pleomorphism (variability of nuclei) in breast carcinoma is one component of the Nottingham histologic grade (NHG) [LOINC: 44648-4], which is a prognostic indicator for patients with breast carcinoma. The two other components of the NHG are tubule formation [LOINC: 85321-8] and mitotic activity [LOINC: 85300-2]. Increasing degrees of pleomorphism are associated with increasingly aggressive cancers, with scores assigned as follows:
1 = no pleomorphism
2 = moderate pleomorphism
3 = extensive pleomorphism
PMID: 11865000 Source: Regenstrief LOINC

Fully-Specified Name

Component
Nuclear pleomorphism
Property
Score
Time
Pt
System
Breast tumor
Scale
SemiQn
Method
Nottingham

Additional Names

Short Name
Nuc pleomorph BT Nottingham
Display Name
Nuclear pleomorphism Nottingham (Breast tumor) [Score]
Consumer Name Alpha Get Info
Nuclear pleomorphism, Breast Tumor

Normative Answer List: LL4382-9

Source: College of American Pathologists
Answer Code Score Answer ID
Nuclei small with little increase in size in comparison with normal outlines, uniform clear chromatin, little variation in size 1 LA27222-1
Cells larger than normal with open vesicular nuclei, visible nucleo size and shape 2 LA27223-9
Vesicular nuclei, often with prominent nucleoli, exhibited marked occasionally with very large and bizzare forms 3 LA27224-7
Only microinvasion present (not graded) 0 LA27219-7
No residual invasive carcinoma after presurgical (neoadjuvant) therapy 0 LA27220-5
Score cannot be determined 0 LA27221-3

Basic Attributes

Class
PATH.PROTOCOLS.BRST
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.75
Change Reason
Removed Method of CAP because this concept is part of the Nottingham histologic score, and added Method of Nottingham. Also updated Property from Arb to Score and added Normative answer list.
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85904-1 Cancer pathology panel - Breast cancer specimen by CAP cancer protocols

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Pleomorfismo nuclear:Puntuación:Punto temporal:Tumor de mama:Semicuantitativo:Nottingham
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Pleomorfismo nuclear:Puntaje:Punto temporal:Tumor de mama:Ordinal:Nottingham
it-IT Italian (Italy) Pleomorfismo nucleare:Punteggio:Pt:Tumore della mammella:SemiQn:Nottingham
Synonyms: Neoplasia Neoplasia al seno Patologia Petto Protocolli patologia - mammella Punto nel tempo (episodio)
pt-BR Portuguese (Brazil) Pleomorfismo nuclear:Arb:Pt:Tumor mamário:Ord:Protocolos de cancer do CAP
Synonyms: ; Nuc pleomorph; Arbitrary; Point in time; Random; Brst Tumor; Ql; Ordinal; QL; Qualitative; Qual; Screen; CAP protocol; PATHOLOGY PROTOCOLS BREAST
zh-CN Chinese (China) 核多形性:评分:时间点:乳腺肿瘤:半定量型:诺丁汉法
Synonyms: Nottingham 法 乳房 乳腺（乳房）肿瘤 乳腺病理学原始记录;病理学.方案.乳腺;病理学原始记录.乳腺;病理学方案.乳腺 分值;得分;分数 多形性胞核;多型核现象;核异形性;核异型性 时刻;随机;随意;瞬间 核;胞核 病理学.方案 病理学原始记录 病理学方案 瘤;肿块;赘生物

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=44645-0