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Part Description

LP72992-8   Nuclear pleomorphism
The degree of nuclear pleomorphism (variability of nuclei) in breast carcinoma is one component of the Nottingham histologic grade (NHG) LOINC 44648-4, which is a prognostic indicator for patients with breast carcinoma. The two other components of the NHG are tubule formation LOINC 85321-8 and mitotic activity LOINC 85300-2. Increasing degrees of pleomorphism are associated with increasingly aggressive cancers, with scores assigned as follows:
1 = no pleomorphism
2 = moderate pleomorphism
3 = extensive pleomorphism
PMID: 11865000 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Nuclear pleomorphism:Score:Pt:Breast tumor:SemiQn:Nottingham
Long Common Name
Nuclear pleomorphism in Breast tumor by Nottingham
Short Name
Nuc pleomorph BT Nottingham
Display Name
Nuclear pleomorphism Nottingham (Breast tumor) [Score]
Consumer Name Alpha Get Info
Nuclear pleomorphism, Breast Tumor

Part Model Get Info

  • Component
    Nuclear pleomorphism
    LP72992-8
    • Analyte
      Nuclear pleomorphism
      LP72992-8
      • Component Numerator
        Nuclear pleomorphism
        LP72992-8
        • Component Numerator Core
          Nuclear pleomorphism
          LP72992-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Score
    LP185820-0
  • Time
    Pt
    LP6960-1
  • System
    Breast tumor
    LP36755-4
    • System Core
      Breast tumor
      LP36755-4
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    Nottingham
    LP248063-2

Normative Answer List: LL4382-9

Source: College of American Pathologists
AnswerCodeScoreAnswer ID
Nuclei small with little increase in size in comparison with normal outlines, uniform clear chromatin, little variation in size1LA27222-1
Cells larger than normal with open vesicular nuclei, visible nucleo size and shape2LA27223-9
Vesicular nuclei, often with prominent nucleoli, exhibited marked occasionally with very large and bizzare forms3LA27224-7
Only microinvasion present (not graded)0LA27219-7
No residual invasive carcinoma after presurgical (neoadjuvant) therapy0LA27220-5
Score cannot be determined0LA27221-3

Basic Attributes

Class
PATH.PROTOCOLS.BRST
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.75 (MAJ)
Change Reason
Removed Method of CAP because this concept is part of the Nottingham histologic score, and added Method of Nottingham. Also updated Property from Arb to Score and added Normative answer list.
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
85904-1Cancer pathology panel - Breast cancer specimen by CAP cancer protocols

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Jaderná pleomorfie:Skóre:Časový bod:Prs nádor:Semikvantitativní:Nottinghamská klasifikace
el-GRGreek (Greece)Πυρηνικός πλειομορφισμός:Βαθμολογία:Pt:Όγκος μαστού:Ημιποσοτική:Nottingham
Synonyms: Nottingham PATH PATH.PROTOCOLS.BRST Pt Βαθμολογία Ημιποσοτική Μαστός Όγκος Όγκος μαστού Πυρηνικό Πυρηνικός πλειομορφισμός
es-ESSpanish (Spain)Pleomorfismo nuclear:Puntuación:Punto temporal:Tumor de mama:Semicuantitativo:Nottingham
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Pleomorfismo nuclear:Puntaje:Punto temporal:Tumor de mama:Ordinal:Nottingham
it-ITItalian (Italy)Pleomorfismo nucleare:Punteggio:Pt:Tumore della mammella:SemiQn:Nottingham
Synonyms: Neoplasia Neoplasia al seno Patologia Petto Protocolli patologia - mammella Punto nel tempo (episodio)
pl-PLPolish (Poland)Pleomorfizm jądrowy:liczba punktów:punkt w czasie:guz piersi:półilościowy:Nottingham
Synonyms: pierś
pt-BRPortuguese (Brazil)Pleomorfismo nuclear:Arb:Pt:Tumor mamário:Ord:Protocolos de cancer do CAP
Synonyms: ; Nuc pleomorph; Arbitrary; Point in time; Random; Brst Tumor; Ql; Ordinal; QL; Qualitative; Qual; Screen; CAP protocol; PATHOLOGY PROTOCOLS BREAST
zh-CNChinese (China)核多形性:评分:时间点:乳腺肿瘤:半定量型:诺丁汉法
Synonyms: Nottingham 法 乳房 乳腺（乳房）肿瘤 乳腺病理学原始记录;病理学.方案.乳腺;病理学原始记录.乳腺;病理学方案.乳腺 分值;得分;分数 多形性胞核;多型核现象;核异形性;核异型性 时刻;随机;随意;瞬间 核;胞核 病理学.方案 病理学原始记录 病理学方案 瘤;肿块;赘生物

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=44645-0