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Term Description

Nottingham histologic grade (NHG) is a prognostic indicator for patients with breast carcinoma. The NHG is based on a combination of individual scores for the degree of tubule formation LOINC 85321-8, nuclear pleomorphism LOINC 44645-0, and mitotic activity LOINC 85300-2. Each parameter is given a score from 1 to 3, and the final NGH grade is determined based on the sum of those three scores. Grade 1 is assigned for a summed score of 3, 4 or 5; grade 2 is assigned for a summed score of 6 or 7; and grade 3 is assigned for a summed score of 8 or 9. A higher grade is associated with a more aggressive cancer, and patients with grade 3 carcinoma tend to have lower long-term survival rates compared to patients with grade 1. The individual tubule formation and mitotic activity scores may also be independent predictors of survival. PMID: 11865000
Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Histologic grade:Score:Pt:Breast cancer specimen:SemiQn:Nottingham
Long Common Name
Histologic grade [Score] in Breast cancer specimen by Nottingham
Short Name
Histo grade Scre Br ca spec Nottingham
Display Name
Histologic grade Nottingham (Breast cancer specimen) [Score]
Consumer Name Alpha Get Info
Histologic grade, Breast cancer specimen

Part Model Get Info

  • Component
    Histologic grade
    LP94898-1
    • Analyte
      Histologic grade
      LP94898-1
      • Component Numerator
        Histologic grade
        LP94898-1
        • Component Numerator Core
          Histologic grade
          LP94898-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Score
    LP185820-0
  • Time
    Pt
    LP6960-1
  • System
    Breast cancer specimen
    LP247851-1
    • System Core
      Breast cancer specimen
      LP247851-1
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    Nottingham
    LP248063-2

Normative Answer List: LL4561-8

Source: College of American Pathologists
AnswerCodeScoreAnswer ID
Nottingham grade 1

Scores of 3, 4 or 5

LA27823-6
Nottingham grade 2

Scores of 6 or 7

LA27824-4
Nottingham grade 3

Scores of 8 or 9

LA27825-1
Only microinvasion present (not graded)LA27219-7
No residual invasive carcinoma after presurgical (neoadjuvant) therapyLA27220-5
Score cannot be determinedLA27221-3

Basic Attributes

Class
PATH.HISTO
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.82 (MIN)
Change Reason
Removed CAP Copyright and Method because this concept is not specific to CAP, moved Nottingham from Component to Method, changed System from "Breast tumor" because the concept is specific to breast cancer, added answer list
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
85904-1Cancer pathology panel - Breast cancer specimen by CAP cancer protocols

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Histologický stupeň:Skóre:Časový bod:Vzorek karcinomu prsu:Semikvantitativní:Nottinghamská klasifikace
el-GRGreek (Greece)Ιστολογικός βαθμός:Βαθμολογία:Pt:Δείγμα καρκίνου του μαστού:Ημιποσοτική:Nottingham
Synonyms: Nottingham PATH PATH.HISTO Pt Βαθμολογία Βαθμός Δείγμα Δείγμα καρκίνου Δείγμα καρκίνου του μαστού Ημιποσοτική Ιστολογικός βαθμός Καρκίνος Μαστός
es-ESSpanish (Spain)Grado histológico:Puntuación:Punto temporal:Muestra de cancer de mama:Semicuantitativo:Nottingham
Synonyms: Histologia Semicuantitativo
es-MXSpanish (Mexico)Grado histológico:Puntaje:Punto temporal:Muestra de cáncer de mama:Ordinal:Nottingham
it-ITItalian (Italy)Grado istologico:Punteggio:Pt:Tumore della mammella, campione:SemiQn:Nottingham
Synonyms: Campione di tumore Campione di tumore della mammella Istologia Neoplasia maligna Patologia Petto Punto nel tempo (episodio)
pl-PLPolish (Poland)Stopień histologiczny:liczba punktów:punkt w czasie:próbka nowotwór piersi:półilościowy:Nottingham
Synonyms: nowotwór pierś
zh-CNChinese (China)组织学分级:评分:时间点:乳腺癌标本:半定量型:诺丁汉法
Synonyms: Nottingham 法 乳房 乳腺癌（乳癌）标本（样本、样品、试样） 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分值;得分;分数 受检物 时刻;随机;随意;瞬间 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 级;品级;成绩;评分;级别;等;等级;年级;分级 组织学 组织学（组织）分级（等级、级别）;组织分级;組織分級 试样

Example Units

UnitSource
{score}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=44648-4