44794-6

Aquaporin 4 water channel IgG Ab [Titer] in Serum or Plasma by Immunofluorescence

Active

Part Description

LP39188-5 Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome. PMID: 17706564 Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Aquaporin 4 water channel Ab.IgG:Titr:Pt:Ser/Plas:SemiQn:IF
Long Common Name: Aquaporin 4 water channel IgG Ab [Titer] in Serum or Plasma by Immunofluorescence
Short Name: AQP4 H2O channel IgG Titr SerPl IF
Display Name: Aquaporin 4 water channel IgG IF [Titer]
Consumer Name Alpha Get Info: Aquaporin 4 water channel IgG antibody, Blood

Part Model Get Info

Component
Aquaporin 4 water channel Ab.IgG
LP39188-5
- Analyte
  Aquaporin 4 water channel Ab.IgG
  LP39188-5
  - Component Numerator
    Aquaporin 4 water channel Ab.IgG
    LP39188-5
    - Component Numerator Core
      Aquaporin 4 water channel
      LP102619-6
    - Component Numerator Core Suffix
      Ab.IgG
      LP32401-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Titr
LP6881-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
SemiQn
LP436123-6
Method
IF
LP6323-2

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.17
Last Updated: Version 2.75 (MAJ)
Change Reason: Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature
Order vs. Observation: Both
Common Test Rank Get Info: 10470

Member of these Groups Get Info

LOINC Group	Group Name
LG17838-0	Aquaporin 4 water channel Ab.IgG\|Titr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Akvaporin 4 IgG:Arbitrární koncentrace (titr):Časový bod:Sérum/plazma:Semikvantitativní:Imunofluoresecence (IF)
de-DE	German (Germany)	Aquaporin-4-Wasserkanal Ak.IgG:Titer:Zeitpunkt:Serum oder Plasma:Semiquantitativ:Immunfluoreszenztest
el-GR	Greek (Greece)	Δίαυλος ύδατος ακουαπορίνης 4 Αντισώματα IgG:Titr:Pt:Ορός/Πλάσμα:Ημιποσοτική:Ανοσοφθορισμός Synonyms: Pt SERO Titr Ανοσοσφαιρίνη G Ανοσοφθορισμός Αντίσωμα Αντισώματα IgG Δίαυλος ύδατος ακουαπορίνης 4 Ημιποσοτική Νερό Ορός Ορός/Πλάσμα Πλάσμα
es-MX	Spanish (Mexico)	Acuaporina 4 canal de agua Ab.IgG:Título:Punto temporal:Suero o Plasma:Cuantitativo:Inmunofluorescencia (IF)
es-ES	Spanish (Spain)	Receptor de Acuaporina 4 IgG:Titulo / Factor de dilución:Punto temporal:Suero o Plasma:Semicuantitativo:Inmunofluorescencia (IF) Synonyms: Semicuantitativo
fr-CA	French (Canada)	Canal de l'eau Aquaporin 4, IgG:Titre:Temps ponctuel:Sérum/Plasma:SemiQn:Immunofluorescence
fr-FR	French (France)	Aquaporine 4 récepteur Ac IgG:Titre:Ponctuel:Sérum/Plasma:Semi-Quantitatif:Immunofluorescence
it-IT	Italian (Italy)	Acquaporina 4, canale idrico Ab.IgG:Titr:Pt:Siero/Plasma:SemiQn:IF Synonyms: anticorpi IgG anticorpo Canale idrico dell''acquaporina 4 Immunofluorescenza (IF) Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NL	Dutch (Netherlands)	aquaporine 4 waterkanaal As.IgG:titer:moment:serum of plasma:semikwantitatief:immunofluorescentie Synonyms: antistof; antilichaam IF
pt-BR	Portuguese (Brazil)	Neuromyelitis optica Ac.IgG:Título:Pt:Sor/Plas:Qn:Imunofluorescência Synonyms: ; NMO; Devic's disease; Immune globulin G; Immunoglobulin G; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; ACIF; FA; Fluorescent antibody; Immune fluorescence; Fluoresent; Immunoflour; Immunofluor; Immunofluorescence; IFA; Time Resolved Fluorescence; Anticomplement Immunofluorescence; TRF; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
uk-UA	Ukrainian (Ukraine)	Аквапорин-4 водний канал Антитіла. IgG:Титр:МоментЧасу:Сироватка/Плазма:Кількісно:Імунофлуоресценція Synonyms: ABS; Aby; ACIF; Antby; Anti; Antibodies; Antibody; Anticomplement Immunofluorescence; AQP4; AQP4 H2O channel; Autoantibodies; Autoantibody; Devic's disease; Dilution factor; Dilution Factor (Titer); FA; Fluorescent antibody; Fluoresent; IFA; Immune fluorescence; Immune globulin G; Immunoflour; Immunofluor; Immunofluorescence; Immunoglobulin G; Neuromyelitis optica; NMO; NMO spectrum disorders; NMOSD; Opticospinal multiple sclerosis; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; Serology; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; Time Resolved Fluorescence; Titer; Titered; Titre; TRF; Ttr; Water channel aquaporin-4
zh-CN	Chinese (China)	水通道蛋白 4 受体抗体.IgG:滴定度:时间点:血清/血浆:半定量型:免疫荧光法 Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 Devic 氏综合征 IgG Devic 综合征 IgG Devic氏综合征 Ab.IgG Devic氏综合征抗体.IgG Devic综合征 Ab.IgG Devic综合征抗体.IgG H2O IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体 NMO Ab.IgG NMO 抗体.IgG 免疫球蛋白 G 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数时刻;随机;随意;瞬间血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类血清或血浆视神经脊髓炎 Ab.IgG 视神经脊髓炎 IgG

Example Units

Unit	Source
{titer}	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=44794-6

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.