45313-4

Coproporphyrin 1/Creatinine [Molar ratio] in Urine

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Part Descriptions

LP18633-5   Coproporphyrin 1
Coproporhyrin I is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin I is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Corproporphyrin I

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component

Coproporphyrin 1/Creatinine

Property

SRto

Time

Pt

System

Urine

Scale

Qn

Method

Additional Names

Short Name

Copro1/Creat Ur-sRto

Display Name

Coproporphyrin 1/Creatinine (U) [Molar ratio]

Consumer Name Alpha Get Info

Coproporphyrin 1/Creatinine, Urine

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.17

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

5913

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Chemistry
• Copro
• Copro1
• Coproporph
• Coproporphyrin I
• Coproporphyrins
• CR
• Crea
• Creat
• i
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Scrto
• Substance concentration ratio
• Substance ratio
• Tetracarboxyl porphyrin
• Tetracarboxylporphyrin
• Tetracarboxylporphyrins
• Tetracarboxyporphyrin
• UA
• UCr
• UR
• Urn

Example Units

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