46434-7
t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Active
Term Description
Ratio of BCR-ABL1 compared to ABL1 (control gene).
Part Description
LP150238-6 t(9;22)(q34.1;q11)(ABL1,BCR)
Chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML) are associated with the fusion of the breakpoint cluster gene (BCR) at chromosome 22q11 to the Abelson gene (ABL1) at chromosome 9q23. The t(9;22)(BCR-ABL1) gene translocation leads to the cytogenetic finding known as the Philadelphia chromsome (Ph'). Various breakpoints within the BCR and ABL1 genes have been described. Most cases of CML are due to a fusion of BCR exon 13 (e13 or b2) or BCR exon 14 (e14 or b3) to the ABL exon 2 (a2). The b2a2 (e13a2) and b3a2 (e14a2) fused transcripts, also known as major break points, produce a 210-kDa protein (p210). The fused transcript resulting in a 190-kDa protein (e1a2 or less common e1a3), also known as minor break points, is found in approximately 75% of childhood ALL patients and 50% of adult ALL patients. Other rarely reported fused transcripts include e6a2, e19a2 (p230), e13a3, and e14a3.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript
- Property
- NRto
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Qn
- Method
- Molgen
Additional Names
- Long Common Name
- t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
- Short Name
- t(9;22)(ABL1,BCR)/control Bld/T
- Display Name
- t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]
- Consumer Name Alpha Get Info
- t(9;22)(q34.1;q11)(ABL1,BCR)/control Transcript, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.TRNLOC
- Type
- Laboratory
- First Released
- Version 2.19
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- We believe this term was incorrectly stated as BCR/ABL based on original submission and knowledge of this test. Corrected Component to accurately represent testing for BCR-ABL1 transcripts compared to a control gene (e.g. ABL1).
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 9975
Member of these Panels
LOINC | Long Common Name |
---|---|
72104-3 | Acute and chronic leukemia fusion transcript per control transcript panel - Blood or Tissue by Molecular genetics method |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
de-AT | German (Austria) | Synonyms: BCR-ABL Translokation (9,22) Ratio |
el-GR | Greek (Greece) | t(9; Synonyms: NRto t(9; |
es-ES | Spanish (Spain) | t(9; Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | t (9; |
fr-FR | French (France) | t(9; |
fr-CA | French (Canada) | t(9; |
it-IT | Italian (Italy) | t(9; Synonyms: Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Sangue Sangue o Tessuto Tessuto & |
ko-KR | Korean (Korea, Republic Of) | 비시알/에비엘: |
nl-NL | Dutch (Netherlands) | t(9; Synonyms: molgen |
pt-BR | Portuguese (Brazil) | BCR/ABL: Synonyms: Number ratio; |
ru-RU | Russian (Russian Federation) | t(9; Synonyms: Количественное отношение Количественный Кровь Кровь или Ткань Ткань и мазки Точка во времени; |
tr-TR | Turkish (Turkey) | t(9; |
zh-CN | Chinese (China) | t(9; Synonyms: ABL CML JTK7 p150 v-abl Abelson murine leukemia viral oncogene homolog 1 v-abl Abelson 小鼠白血病病毒癌基因同源体 1 v-abl Abelson 小鼠白血病病毒肿瘤基因同源体 1 v-abl Abelson 小鼠白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科动物白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科白血病病毒致癌基因同源体 1 全血或组织; |
Example Units
Unit | Source |
---|---|
ratio | REGENSTRIEF |
{ratio} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=46434-7
LOINC Copyright
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