47741-4
Purine nucleoside phosphorylase [Entitic Catalytic Activity] in Leukocytes
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Part Description
LP15841-7 Purine nucleoside phosphorylase
Purine nucleoside phosphorylase (also known as PNPase) is an enzyme (EC 2.4.2.1) involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine, in each case creating ribose phosphate. NP encodes the enzyme purine nucleoside phosphorylase that, together with adenosine deaminase (ADA), serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in ADA lead to an accumulation of (d)ATP, which inhibits ribonucleotide reductase, leading to a deficiency in (d)CTPs and (d)TTPs, which, in turn, induces apoptosis in T-lymphocytes and B-lymphocytes, leading to severe combined immunodeficiency (SCID).
PNP-deficient patients will have an immunodeficiency problem. It affects only T-cells; B-cells are unaffected by the deficiency.
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Source: Wikipedia
, Wikipedia
Fully-Specified Name
- Component
- Purine nucleoside phosphorylase
- Property
- EntCat
- Time
- Pt
- System
- WBC
- Scale
- Qn
- Method
Additional Names
- Long Common Name
- Purine nucleoside phosphorylase [Entitic Catalytic Activity] in Leukocytes
- Short Name
- PNP WBC Qn
- Display Name
- Purine nucleoside phosphorylase (WBC) [Entitic Catalytic Activity]
- Consumer Name Alpha Get Info
- Purine nucleoside phosphorylase, White blood cells
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.21
- Last Updated
- Version 2.70 (MIN)
- Change Reason
- The property (CCnt) given at creation was not consistent with the submitter's units, nmol/min/10*6 cells, which indicates they report catalytic activity per a given number of cells. Changed property to EntCat (Entitic catalytic activity).
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Φωσφορυλάση πουρινικών νουκλεοσιδίων: Synonyms: EntCat Πουρίνη Φωσφορυλάση Φωσφορυλάση πουρινικών νουκλεοσιδίων |
| es-ES | Spanish (Spain) | Purin nucleósido fosforilasa: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Purina nucleósido fosforilasa: |
| fr-CA | French (Canada) | Purine-nucléoside phosphorylase: |
| fr-FR | French (France) | Purine nucléoside phosphorylase: |
| fr-BE | French (Belgium) | Purine-nucléoside phosphorylase: |
| it-IT | Italian (Italy) | Purina nucleoside fosforilasi: Synonyms: Attività Catalitica Entitica Chimica Globuli bianchi PNPasi Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | purinenucleosidefosforylase: Synonyms: witte bloedcellen |
| pl-PL | Polish (Poland) | Fosforylaza nukleozydów purynowych: |
| pt-BR | Portuguese (Brazil) | Purina nucleosídeo fosforilase: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Пуриновых нуклеозидов фосфорилаза: Synonyms: Количественный Сущность каталитическая активность Точка во времени; |
| tr-TR | Turkish (Turkey) | Pürin nukleozid fosforilaz: Synonyms: WBC |
| zh-CN | Chinese (China) | 嘌呤核苷酸磷酸化酶: Synonyms: PNP WBC; |
Example Units
| Unit | Source |
|---|---|
| nmol/min/10*6{cells} | Example UCUM Units |
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