48647-2
Ej Ab [Presence] in Serum by Radioimmunoprecipitation assay (RIPA)
Active
Part Description
LP36852-9 Ej
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes.
Source: Regenstrief LOINC, PMID: 23573256
Fully-Specified Name
- Component
- Ej Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- RIPA
Additional Names
- Short Name
- Ej Ab Ser Ql RIPA
- Display Name
- Ej Ab RIPA Ql (S)
- Consumer Name Alpha Get Info
- Ej antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.21
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 19382
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG18029-5 | Ej Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Ej Anticuerpos: |
| es-MX | Spanish (Mexico) | Ej Ab: |
| fr-CA | French (Canada) | Ej, Ac: |
| fr-FR | French (France) | Ej anticorps: |
| fr-BE | French (Belgium) | Ej Ac: Synonyms: Anticorps RIP |
| it-IT | Italian (Italy) | Ej Ab: Synonyms: anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Test di Radioimmunoprecipitazione (RIPA) |
| nl-NL | Dutch (Netherlands) | ej As: Synonyms: antistof; |
| pt-BR | Portuguese (Brazil) | Ej Ac: Synonyms: Glycyl tRNA synthetase; |
| tr-TR | Turkish (Turkey) | Ej Ab: Synonyms: Ak Mevcut |
| zh-CN | Chinese (China) | Ej 抗体: Synonyms: Ab; |
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LOINC Copyright
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