50097-5

21-Deoxycortisol [Moles/volume] in Serum or Plasma --1 hour post 250 ug corticotropin

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Part Description

LP65144-5 21-Deoxycortisol
Plasma 21-deoxycortisol (21DF) is an excellent marker of 21-hydroxylase deficiency. Currently, it is the only marker able to detect heterozygous carriers with 21-hydroxylase deficiency after Adrenocorticotropic Hormone (ACTH) stimulation. The syndrome of congenital adrenal hyperplasia (CAH) comprises the spectrum of autosomal recessive enzymatic disorders that impair cortisol biosynthesis. The hormonal pattern and clinical manifestations result from hyperstimulation of the adrenal cortex by excessive production of ACTH, untied from the negative feedback exerted by reduced cortisol levels, and the ultimate accumulation of F precursors and androgens. These abnormalities predispose the female newborn to ambiguous genitalia (female pseudohermaphroditism) and precocious puberty that may occur in both sexes. CAH due to 21-hydroxylase deficiency (21OHD) comprises nearly 90% of all cases, with an estimated worldwide incidence of 1 in 14,000 live births. Because 21-deoxycortisol (21DF) is an 11b-hydroxylase (11bOH) derivative of 17-hydroxyprogesterone (17OHP), its serum levels are parallel and proportionally elevated in patients with 21OHD but decreased or undetectable in those with 11b-hydroxylase deficiency (11bOHD). Due to the marked buildup of 17OHP in 21OHD, this precursor steroid can proceed directly to 11-hydroxylation, producing distinct elevations of 21DF. PMID: 16551734, PMID: 10731638 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database , 21-Deoxycortisol

Fully-Specified Name

Component: 21-Deoxycortisol^1H post 250 ug corticotropin
Property: SCnc
Time: Pt
System: Ser/Plas
Scale: Qn
Method

Additional Names

Long Common Name: 21-Deoxycortisol [Moles/volume] in Serum or Plasma --1 hour post 250 ug corticotropin
Short Name: 21DC 1h p 250 ug ACTH SerPl-sCnc
Display Name: 21-Deoxycortisol 1 Hr post 250 ug corticotropin [Moles/Vol]
Consumer Name Alpha Get Info: 21-Deoxycortisol 1 hr after 250 ug Corticotropin, Blood

Basic Attributes

Class: CHAL
Type: Laboratory
First Released: Version 2.22
Last Updated: Version 2.70 (MIN)
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	21-δεοξυκορτιζόλη^1 ώρα κατόπιν 250 ug κορτικοτροπίνης:SCnc:Pt:Ορός/Πλάσμα:Qn: Synonyms: 21-δεοξυκορτιζόλη SCnc Κορτικοτροπίνη
es-ES	Spanish (Spain)	21-Deoxicortisol^1 hora pos 250 ug corticotropina:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	21-Deoxicortisol^1H después de 250 ug de corticotropina:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
fr-CA	French (Canada)	21-désoxycortisol^1 h post 250 ug hormone adrénocorticotrope:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR	French (France)	21-déoxycortisol T01h après synacthène (250µg):Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE	French (Belgium)	21-déoxycortisol^1 h post 250 ug hormone adrénocorticotrope:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif: Synonyms: 1h après ACTH 250µg ACTH
it-IT	Italian (Italy)	21-Deossicortisolo^1h post 250 ug corticotropina:SCnc:Pt:Siero/Plasma:Qn: Synonyms: 1 ora dopo 250 ug di corticotropina Concentrazione di Sostanza Plasma Punto nel tempo (episodio) Siero Siero o Plasma Test di provocazione
nl-NL	Dutch (Netherlands)	21-deoxycortisol^60 min na 250 ug ACTH:mol/volume:moment:serum of plasma:kwantitatief: Synonyms: 1 uur na 250 ug ACTH adrenocorticotroop hormoon; adrenocorticotrofine; corticotrofine
pt-BR	Portuguese (Brazil)	21-Deoxicortisol^60 min após 250 ug corticotrofina:SCnc:Pt:Sor/Plas:Qn: Synonyms: ; ACTH; Rc206; c74; Cortrosyn; c206; Adrenocorticotropin; Adrenocorticotrophic hormone; 21DC; 1H p 250 ug ACTH; Substance concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; mcg; PST; After; CHEMISTRY.CHALLENGE TESTING; CHEMISTRY.CHALLENGE TESTING
ru-RU	Russian (Russian Federation)	21-Дезоксикортизол^1 час после 250 мкг кортикотропина:МолКонц:ТчкВрм:Сыв/Плаз:Колич: Synonyms: Количественный Молярность;Молярная объёмная концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	21-Deoksikortizol^1Sa snr 250 ug kortikotropin:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CN	Chinese (China)	21-脱氧皮质醇^在给予250 ug促肾上腺皮质激素之后1小时:物质的量浓度:时间点:血清/血浆:定量型: Synonyms: 1Hr之后于给予250 ug促肾上腺皮质激素;1Hr之后于给予250微克促肾上腺皮质激素;1小时之后于给予250 ug促肾上腺皮质激素;1小时之后于给予250微克促肾上腺皮质激素;60Min之后于给予250 ug促肾上腺皮质激素;60Min之后于给予250微克促肾上腺皮质激素;60分钟之后于给予250 ug促肾上腺皮质激素;60分钟之后于给予250微克促肾上腺皮质激素;在给予250 ug促肾上腺皮质激素之后1Hr;在给予250 ug促肾上腺皮质激素之后60Min;在给予250 ug促肾上腺皮质激素之后60 21DC;21-脱氧可的索;21-脱氧氢化可的松;21-脱氧皮质甾醇;21-脱氧考的索 ACTH ACTH;亲皮质素;促皮质素 ug XXX刺激 - 在...之后 μg 之后于... 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺在...以后在后时刻;随机;随意;瞬间血清或血浆

Example Units

Unit	Source
nmol/L	Example UCUM Units

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