50195-7

t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript [Log Number Ratio] in Blood or Tissue by Molecular genetics method

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Term Description

BCR/ABL Ratio.
(BCR=Breakpoint Cluster Region and ABL=Abelson) The level of fusion gene transcript in the test sample is expressed as a log reduction; i.e., log10 of the ratio of chimeric BCR-ABL/normal ABL mRNA transcript seen in individuals with untreated CML (Chronic Myelogenous Leukemia) as compared to the ratio seen in the patient. In Quest's laboratory data, the median of BCR-ABL/ABL Ratio in previously untreated CML patients is 4.1325 in peripheral blood samples (N=120) and 5.09 in bone marrow samples (N=109). Based on the IRIS study (New England Journal of Medicine, 2003, 3349:1423-1432), it is not necessary to know the BCR-ABL:ABL ratio of a patient at baseline to calculate the subsequent change and this calculation should be based on the above-mentioned median. Based on this study, a 3 log of higher reduction by 12 months of therapy is associated with negligible risk of disease progression during the subsequent 12 months with patients are treated with imatinib. The following formula is used for calculating log reduction by Quest Laboratories: LOG10(4.1325)-LOG10 (BCR-ABL:ABL ratio) Unit/Log Reduction. Information from Quest Diagnostics. 2006 12 06.
Source: Regenstrief Institute

Part Description

LP150238-6 t(9;22)(q34.1;q11)(ABL1,BCR)
Chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML) are associated with the fusion of the breakpoint cluster gene (BCR) at chromosome 22q11 to the Abelson gene (ABL1) at chromosome 9q23. The t(9;22)(BCR-ABL1) gene translocation leads to the cytogenetic finding known as the Philadelphia chromsome (Ph'). Various breakpoints within the BCR and ABL1 genes have been described. Most cases of CML are due to a fusion of BCR exon 13 (e13 or b2) or BCR exon 14 (e14 or b3) to the ABL exon 2 (a2). The b2a2 (e13a2) and b3a2 (e14a2) fused transcripts, also known as major break points, produce a 210-kDa protein (p210). The fused transcript resulting in a 190-kDa protein (e1a2 or less common e1a3), also known as minor break points, is found in approximately 75% of childhood ALL patients and 50% of adult ALL patients. Other rarely reported fused transcripts include e6a2, e19a2 (p230), e13a3, and e14a3. Source: Regenstrief LOINC

Fully-Specified Name

Component: t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript
Property: LnRto
Time: Pt
System: Bld/Tiss
Scale: Qn
Method: Molgen

Additional Names

Long Common Name: t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript [Log Number Ratio] in Blood or Tissue by Molecular genetics method
Short Name: t(9;22)(ABL1,BCR)/control Bld/T-LnRto
Display Name: t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript Molgen (Bld/Tiss) [Log # ratio]
Consumer Name Alpha Get Info: t(9;22)(q34.1;q11)(ABL1,BCR)/control Transcript, Blood or tissue specimen

Basic Attributes

Class: MOLPATH.TRNLOC
Type: Laboratory
First Released: Version 2.22
Last Updated: Version 2.73 (MIN)
Change Reason: Component part BCR/ABL for this term was erroneous. Edited to represent what is really being measured and to harmonize with current LOINC nomenclature.
Order vs. Observation: Observation
Common Test Rank Get Info: 12833

Formula (Readable)

LOG10(4.1325)-LOG10(BCR-ABL:ABL ratio) Unit/Log Reduction

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	t(9;22)(q34.1;q11)(ABL1,BCR) μεταγραφή συγχώνευσης/μεταγραφή ελέγχου:LnRto:Pt:Αίμα/Ιστός:Qn:Μοριακή γενετική Synonyms: LnRto t(9;22)(q34.1;q11)(ABL1,BCR)
es-ES	Spanish (Spain)	t(9;22)(q34.1;q11)(ABL1,BCR) Tránscritos de fusión/transcrito control:Proporción de número logarítmico:Punto temporal:Sangre o tejido:Qn:Genética molecular Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	t (9; 22) (q34.1; q11) (ABL1, BCR) transcripción de fusión / transcripción de control:Relación de número de registro:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-CA	French (Canada)	t(9;22)(q34.1;q11)(ABL1,BCR) transcrit de fusion/Transcrit de contrôle:Ratio des nombres logarithmiques:Temps ponctuel:Sang/Tissu:Quantitatif:Molgen
fr-FR	French (France)	t(9;22)(q34.1;q11)(ABL1,BCR) transcrit de fusion/transcrit de référence:Nombre (Log ratio):Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
it-IT	Italian (Italy)	t(9;22)(q34.1;q11)(ABL1,BCR), trascritto di fusione/trascritto di controllo:LnRto:Pt:Sangue/Tess:Qn:Molgen Synonyms: Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Rapporto logaritmico Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
nl-NL	Dutch (Netherlands)	t(9;22)(q34.1;q11)(ABL1,BCR) fusietranscript/controle transcript:logaritmisch aantal verhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek Synonyms: molgen
pt-BR	Portuguese (Brazil)	BCR-ABL:LnRto:Pt:Sg/Tecido:Qn:Genética molecular Synonyms: Log number ratio; Log Nrto; Point in time; Random; Bld/T; Tissue; Bld/T; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; PCR; Molecular genetics; ALL; BCR1; Chronic myeloid leukemia; CML; Breakpoint cluster region; D22S11; D22S662; PHL; MOLPATH.TRANSLOCATION; MOLPATH.TRANSLOCATION; Molecular pathology
ru-RU	Russian (Russian Federation)	t(9;22)(q34.1;q11)(ABL1,BCR) слияния транскрипт/контрольный транскрипт:ЛогОтн:ТчкВрм:Кр/Тк:Колич:МолГен Synonyms: Количественный Кровь Кровь или Ткань Логарифмическое количеств отношение Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TR	Turkish (Turkey)	t(9;22)(q34.1;q11)(ABL1,BCR) füzyon transkript/kontrol transkripti:LnOran:Zmlı:Kan/Dk:Kant:Molgen
zh-CN	Chinese (China)	t(9;22)(q34.1;q11)(ABL1,BCR) 融合转录物/对照转录物:对数型数量或计数比率:时间点:全血/组织:定量型:分子遗传学类实验室方法 Synonyms: ABL CML JTK7 p150 v-abl Abelson murine leukemia viral oncogene homolog 1 v-abl Abelson 小鼠白血病病毒癌基因同源体 1 v-abl Abelson 小鼠白血病病毒肿瘤基因同源体 1 v-abl Abelson 小鼠白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科动物白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科白血病病毒致癌基因同源体 1 全血或组织;血液/组织;血液或组织分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位分子病理学;分子病理学试验分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应可用数量表示的;定量性;数值型;数量型;连续数值型标尺对数型数量或计数比;对数型数量比;对数型数量比率;对数型计数比;对数型计数比率;数量或计数型比之对数;数量或计数型比率之对数对照转录物（转录本、转录产物、转录子、转录）;对照基因转录本;控制转录本慢性粒细胞性白血病慢性粒细胞白血病慢性粒细胞白血病（Chronic myeloid leukemia，CML）慢性髓系白血病断点簇集区断裂点丛集区断裂点簇集区断裂点聚集区断裂点集中区断裂点集中区（Breakpoint cluster region，BCR）时刻;随机;随意;瞬间易位(9;22)(q34.1;q11)(ABL1,BCR) 未作说明的组织;组织;组织 & 涂片融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录血;血液限制性断裂区

Example Units

Unit	Source
{log_reduction}	Example UCUM Units

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Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.