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Part Description

LP207652-1   HIV 1 RNA tropism
HIV enters cells by attaching first to the CD4 receptor and then to either the CCR5 or CXCR4 molecules, followed by fusion of the viral and cellular membranes. CCR5 coreceptor antagonists prevent HIV entry into target cells by binding to the CCR5 receptors. HIV tropism assays determine whether the HIV binds to CCR5, CXCR4 or both. An HIV tropism assay should be performed whenever the use of a CCR5 antagonist is being considered or a patient has virologic failure on a CCR5 antagonist.
During acute or recent infection, the vast majority of patients harbor a CCR5-binding virus (called R5 tropism), which suggests that the R5 variant is preferentially transmitted. Viruses in many untreated patients exhibit a shift in co-receptor tropism from CCR5 usage to either CXCR4 (X4 tropism) or both (D/M-tropic, which stands for dual or mixed), which is associated with a more rapid decline in CD4 T-cell counts. Patients who have been treated with anti-retroviral drugs and who have extensive drug resistance are more likely to harbor X4- or D/M-tropic variants than untreated patients with comparable CD4 counts. The prevalence of X4- or D/M-tropic variants increases to more than 50% in treated patients who have CD4 counts <100 cells/mm3. https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf Source: Regenstrief LOINC, NIH adult and adolescent HIV guidelines

LOINC Names Get Info

Fully-Specified Name
HIV 1 RNA tropism:Prid:Pt:Isolate:Nom:
Long Common Name
HIV 1 RNA tropism [Identifier]
Short Name
HIV1 RNA tropism Islt
Display Name
HIV 1 RNA tropism Nom (Isol)
Consumer Name Alpha Get Info
HIV 1 RNA Tropism

Part Model Get Info

  • Component
    HIV 1 RNA tropism
    LP207652-1
    • Analyte
      HIV 1 RNA tropism
      LP207652-1
      • Component Numerator
        HIV 1 RNA tropism
        LP207652-1
        • Component Numerator Core
          HIV 1 RNA tropism
          LP207652-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    Pt
    LP6960-1
  • System
    Isolate
    LP7370-2
    • System Core
      Isolate
      LP7370-2
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    NULL
     

Example Answer List: LL2265-8

Source: Regenstrief LOINC
AnswerCodeScoreAnswer ID
R5

Viruses or virus populations that use only the CCR5 chemokine co-receptor to infect CD4+ cells.

LA19204-9
X4

Viruses or virus populations that use only the CXCR4 chemokine co-receptor to infect CD4+ cells.

LA19205-6
D/M

Dual (D)-tropic: Viruses or virus populations that can use either the CCR5 or CXCR4 co-receptors to infect CD4+ cells. Mixed (M)-tropic: Virus populations that may contain various combinations of R5 virus, X4 virus, and/or dual-tropic viruses

LA19206-4

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.22
Last Updated
Version 2.73 (MIN)
Change Reason
Changed class from MICRO to ABXBACT because the test result is used to inform anti-retroviral drug choice, added "RNA" to Component to clarify that the tropism is based on viral RNA and not proviral DNA.
Order vs. Observation
Both
Common Test Rank Get Info
11371

Member of these Panels

LOINCLong Common Name
75622-1HIV 1 and 2 tests - Meaningful Use set

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)HIV 1 RNA tropismus:Přítomnost nebo identita:Časový bod:Izolát:Nominální:
el-GRGreek (Greece)Τροπισμός RNA ιού της ανθρώπινης ανοσοανεπάρκειας 1:Prid:Pt:Απομονωμένο στέλεχος:Nom:
Synonyms: ABXBACT HIV 1 Nom Prid Pt RNA RNA ιού της ανθρώπινης ανοσοανεπάρκειας 1 Απομονωμένο στέλεχος Ιός ανθρώπινης ανοσοανεπάρκειας Τροπισμός RNA ιού της ανθρώπινης ανοσοανεπάρκειας 1
es-ESSpanish (Spain)Tropismo del VIH 1 en ARN:Presencia o identidad:Punto temporal:Aislado:Nom:
es-MXSpanish (Mexico)Tropismo del ARN del VIH 1:Presencia o identidad:Punto temporal:Aislado:Nominal:
fr-CAFrench (Canada)VIH 1 ARN tropisme:Présence ou identité:Temps ponctuel:Isolat:Nominal:
fr-FRFrench (France)VIH-1 ARN tropisme:Identification:Ponctuel:Isolat:Résultat nominal:
it-ITItalian (Italy)HIV 1 proviral RNA tropismo:Prid:Pt:Isolato:Nom:
Synonyms: Presenza o Identità Punto nel tempo (episodio) RNA dell''HIV 1 Suscettibilità agli antibiotici
nl-NLDutch (Netherlands)HIV 1 RNA tropisme:identificator:moment:isolaat:nominaal:
pl-PLPolish (Poland)HIV 1 RNA tropizm:obecność lub identyfikacja:punkt w czasie:izolat:skala nominalna:
Synonyms: Ludzki wirus niedoboru odporności Ludzki wirus niedoboru odporności typu 1 RNA ludzkiego wirusa niedoboru odporności typu 1 Tropizm RNA ludzkiego wirusa niedoboru odporności typu 1 wynik kategorialny
pt-BRPortuguese (Brazil)HIV 1 tropismo:Ident:Pt:Isolado:Nom:
Synonyms: ; HIV1 tropism; CCR5; Trofile; Tropotype; CXCR4; R5; X4; CXCR4 (X4); HTLV III; HTLV 3; HIV type 1; HIV type I; AIDS; Human immunodeficiency virus; Identity or presence; Point in time; Random; Islt; Isol; Nominal; Microbiology
uk-UAUkrainian (Ukraine)ВІЛ 1 РНК тропізм:Наявність або Ідентифікація:МоментЧасу:Ізолят:Категорійно:
Synonyms: AIDS; ANTIBIOTIC SUSCEPTIBILITIES; HIV type 1; HIV type I; HIV1; HIV1 RNA tropism; Human immunodeficiency virus; i; ID; Identity or presence; Infectious Disease; InfectiousDisease; Islt; Isol; Nominal; Point in time; Random; Ribonucleic acid
zh-CNChinese (China)HIV 1 型 RNA 嗜性:存在与否或特征标识:时间点:分离株:名义型:
Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） RNA 嗜性（向性、趋性、趋向性） HIV1 RNA HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 存在;存在与否;特征标识;身份;身份标识 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间 核糖核酸;Ribonucleic acid

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