52944-6
Aluminum/Creatinine [Molar ratio] in 24 hour Urine
Active
Part Descriptions
LP16800-2 Aluminum
Aluminium (Al) is a metal which is distributed throughout our environment. It has been used since approximately 1887. Al is widely used in multiple industries and consumer products. It has no known function in biology. Al usually enters the human body via cooking utensils or pharmicological agents such as antacids (Al (OH)3 )and antiperspirants. Aluminum salts are remarkably nontoxic, aluminum sulfate having an LD50 of 6207 mg/kg (oral, mouse), which corresponds to 500 grams for an 80 kg (180 lb) person. Aluminum is excreted by filtration by the glomeruli of the kidney. Patients in renal failure lose the ability to clear aluminum, and aluminum toxicity may be a concern. Aluminum accumulates in the blood and binds to proteins such as albumin, and then distributed throughout the body.Because aluminum competes with calcium for absorption, increased amounts of dietary aluminum may contribute to the reduced skeletal mineralization (osteopenia) observed in preterm infants and infants with growth retardation. In very high doses, aluminum is associated with altered function of the blood-brain barrier. A small percentage of people are allergic to aluminum and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminum. In those without allergies, aluminum is not as toxic as heavy metals, but there is evidence of some toxicity if consumed in amounts greater than 40 mg/day per kg of body mass. Aluminum is classified as a non-carcinogen by the US Department of Health and Human Services. In case of suspected sudden intake of a large amount of aluminum, deferoxamine mesylate may be given to help eliminate it from the body by chelation. (Tietz: Clinical Guide to Laboratory Tests, Fourth Edition)
The mechanism of how the neurotoxicity of AI occurs is still unclear. Evidence suggests that oxidative stress and inflammatory processes lead to cell death. As a neurotoxin, Al is considered has been linked to the development of neurodegenerative diseases, including Alzheimer's disease (AD), dementia, Amyotrophic Lateral Sclerosis (ALS) Parkinsonism and even Gulf war syndrome. PMID: 27479193 (for human medicine)
Veterinary Medicine:
In veterinary medicine, the impact of aluminum toxicity is similar. An animal proven to have aluminum toxicity from an ingested foreign body had symptoms of muscle twitching and convulsions during exercise, which worsened to weakened limbs and coma until the source of the toxicity was removed. PMID: 23609067
Source: Regenstrief LOINC
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database
, Creatinine
Fully-Specified Name
- Component
- Aluminum/Creatinine
- Property
- SRto
- Time
- 24H
- System
- Urine
- Scale
- Qn
- Method
Additional Names
- Long Common Name
- Aluminum/Creatinine [Molar ratio] in 24 hour Urine
- Short Name
- Aluminum/Creat 24h Ur-sRto
- Display Name
- Aluminum/Creatinine (24H U) [Molar ratio]
- Consumer Name Alpha Get Info
- Aluminum/Creatinine, Urine
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.24
- Last Updated
- Version 2.70 (MIN)
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Αλουμίνιο/Κρεατινίνη: Synonyms: SRto Αλουμίνιο Κρεατινίνη |
| es-ES | Spanish (Spain) | Aluminio/Creatinina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Aluminio / Creatinina: |
| fr-CA | French (Canada) | Aluminium/Créatinine: |
| fr-FR | French (France) | Aluminium/créatinine: |
| fr-BE | French (Belgium) | Aluminium/Créatinine: Synonyms: Al |
| it-IT | Italian (Italy) | Alluminio/Creatinina: Synonyms: 24 Ore Livelli farmacologici e tossicologia Rapporto di sostanza |
| nl-NL | Dutch (Netherlands) | aluminium/creatinine: Synonyms: 24U kreatinine |
| pt-BR | Portuguese (Brazil) | Alumínio/Creatinina: Synonyms: AL; |
| ru-RU | Russian (Russian Federation) | Алюминий/Креатинин: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Aluminyum/Kreatinin: Synonyms: SubsOranı |
| zh-CN | Chinese (China) | 铝/肌酐: Synonyms: 1天; |
Example Units
| Unit | Source |
|---|---|
| umol/mol{creat} | Example UCUM Units |
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