Version 2.77

Part Description

LP15684-1   Kynurenate
Kynurenic acid (KYNA) is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive activity. It acts as an antiexcitotoxic and anticonvulsant, most likely through acting as an antagonist at excitatory amino acid receptors. Because of this activity, it may influence important neurophysiologic and neuropathologic processes. As a result, kynurenic acid has been considered for use in therapy in certain neurobiological disorders. Conversely, increased levels of kynurenic acid have also been linked to certain pathological conditions.

High levels of kynurenic acid have been identified in patients suffering from tick-borne encephalitis, schizophrenia and HIV-related illnesses. In all these situations increased levels were associated with confusion and psychotic symptoms. Kynurenic acid acts in the brain as a glycine-site NMDAr antagonist, key in glutamatergic neurotransmission system, which is thought to be involved in the pathophysiology and pathogenesis of schizophrenia.

A kynurenic acid hypothesis of schizophrenia has been proposed in 2007, based on its action on midbrain dopamine activity and NMDArs, thus linking dopamine hypothesis of schizophrenia with the glutamate hypothesis of the disease.

High levels of kynurenic acid have been identified in human urine in certain metabolic disorders, such as marked pyridoxine deficiency and deficiency/absence of kynureninase. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Kynurenic acid

Fully-Specified Name

Component
Kynurenate
Property
SCnc
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Short Name
KYN Ur-sCnc
Display Name
Kynurenate (U) [Moles/Vol]
Consumer Name Alpha Get Info
Kynurenate, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.24
Last Updated
Version 2.75
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG48918-3 Kynurenate|Pt|Urine|189.17 g/mole

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Quinurenato:Concentración de sustancia:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Quinurenato:Concentración de sustancias:Punto temporal:Orina:Cuantitativo:
fr-CA French (Canada) Kynurénate:Concentration de substance:Temps ponctuel:Urine:Quantitatif:
fr-FR French (France) Cynurénate:Moles/Volume:Ponctuel:Urine:Numérique:
fr-BE French (Belgium) Kynurénate:Concentration de substance:Temps ponctuel:Urine:Quantitatif:
it-IT Italian (Italy) Chinurenato:SCnc:Pt:Urine:Qn:
Synonyms: Chimica Concentrazione di Sostanza Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) kynurenaat:mol/volume:moment:urine:kwantitatief:
pt-BR Portuguese (Brazil) Cinurenato:SCnc:Pt:Urina:Qn:
Synonyms: ; Kynuren; KYN; KYNA; Kynurenic acid; Substance concentration; Level; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU Russian (Russian Federation) Кинуренат:МолКонц:ТчкВрм:Моча:Колич:
Synonyms: Количественный Молярность;Молярная объёмная концентрация Точка во времени;Момент
tr-TR Turkish (Turkey) Kinirenat:SubKons:Zmlı:İdrar:Kant:
zh-CN Chinese (China) 犬尿氨酸:物质的量浓度:时间点:尿液:定量型:
Synonyms: KYN;KYNA;犬尿氨酸（Kynurenic acid，KYNA） 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 时刻;随机;随意;瞬间

Example Units

Unit Source
nmol/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53101-2