Version 2.80

Term Description

Glutamic acid decarboxylase (GAD65) is an enzyme that is produced primarily by pancreatic islet cells. Glutamic Acid Decarboxylase antibodies are present in the majority of individuals with new-onset diabetes and in individuals in the prediabetic phase of the disease. It appears early in the disease process prior to clinical symptoms and can be used to predict who will develop IDDM (insulin-dependent diabetes mellitus). Measurement of GAD65 antibody can be of use in distinguishing insulin-dependent from non-insulin dependent diabetics when the clinical history is ambiguous. GAD65 autoantibodies are often markedly elevated in patients with the stiff-person syndrome (also known as stiff-man syndrome), a condition that is associated with fluctuating stiffness and paroxysmal spasms of the trunk and legs. Information from http:www.labcorp.com (Laboratory Corporation of America), accessed 2008 02 13.

Part Description

LP18489-2   Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. PMID: 7532143 GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located. PMID: 22412264 Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases. PMID: 22405456 Source: Regenstrief LOINC

Fully-Specified Name

Component
Glutamate decarboxylase 65 Ab
Property
SCnc
Time
Pt
System
CSF
Scale
Qn
Method

Additional Names

Long Common Name
Glutamate decarboxylase 65 Ab [Moles/volume] in Cerebral spinal fluid
Short Name
GAD65 Ab CSF-sCnc
Display Name
Glutamate decarboxylase 65 Ab (CSF) [Moles/Vol]
Consumer Name Alpha Get Info
Glutamate decarboxylase 65 antibody, Spinal fluid

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
6334

Member of these Groups Get Info

LOINC Group Group Name
LG50994-9 Glutamate decarboxylase 65 Ab|SCnc|Pt|CSF

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Γλουταμινική αποκαρβοξυλάση 65 Αντίσωμα:SCnc:Pt:ΕΝΥ:Qn:
Synonyms: SCnc Γλουταμινική αποκαρβοξυλάση Γλουταμινική αποκαρβοξυλάση 65 Γλουταμινικό οξύ
es-ES Spanish (Spain) Glutamato decarboxilasa 65 Anticuerpos:Concentración de sustancia:Punto temporal:Líquido Cefalorraquideo:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Glutamato descarboxilasa 65 Ab:Concentración de sustancias:Punto temporal:Fluído espinal cerebral:Cuantitativo:
et-EE Estonian (Estonia) Glutamaadi dekarboksülaasi 65 vastased antikehad:SCnc:Pt:CSF:Qn:
Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Liikvor
fr-CA French (Canada) Glutamate décarboxylase 65, Ac:Concentration de substance:Temps ponctuel:LCR:Quantitatif:
fr-FR French (France) Glutamate décarboxylase 65 anticorps:Moles/Volume:Ponctuel:Liquide céphalorachidien:Numérique:
fr-BE French (Belgium) Glutamate décarboxylase 65 Ac:Concentration de substance:Temps ponctuel:LCR:Quantitatif:
Synonyms: Anticorps
it-IT Italian (Italy) Glutammato decarbossilasi 65 Ab:SCnc:Pt:LCS:Qn:
Synonyms: anticorpo Concentrazione di Sostanza GAD65 Liquido cerebrospinale Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) glutamaatdecarboxylase 65 As:mol/volume:moment:liquor cerebrospinalis:kwantitatief:
Synonyms: antistof; antilichaam
pt-BR Portuguese (Brazil) Glutamato Descarboxilase 65 Ac:SCnc:Pt:LCR:Qn:
Synonyms: GADA; GAD65; GAD-65; Glutamic acid decarboxylase-65; Glu; Substance concentration; Level; Point in time; Random; Cerebral spinal fluid; Spinal Fluid; Cerebrospinal Fl; Spinal Flu; Spinal Fld; Quantitative; QNT; Quant; Quan; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU Russian (Russian Federation) Глутаматдекарбоксилаза 65 Ат:МолКонц:ТчкВрм:ЦСЖ:Колич:
Synonyms: Антитело Количественный Молярность;Молярная объёмная концентрация Точка во времени;Момент Цереброспинальная жидкость
tr-TR Turkish (Turkey) Glutamat dekarboksilaz 65 Ab:SubKons:Zmlı:BOS:Kant:
zh-CN Chinese (China) 谷氨酸脱羧酶-65 抗体:物质的量浓度:时间点:脑脊液:定量型:
Synonyms: Ab;自身抗体 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 GAD65;GAD-65;谷氨酸脱羧酶 65;谷氨酸脱羧酶 65（Glutamate Decarboxylase 65，GAD65，Glutamic acid decarboxylase-65，GAD-65） GADA Glu 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 谷氨酸脱羧酶 65 Ab 谷氨酸脱羧酶 65 抗体 谷氨酸脱羧酶-65 Ab 麸胺酸去羧酶;麸胺酸去羧基酶;麸氨酸去羧基酶;GAD

Example Units

Unit Source
nmol/L Example UCUM Units
nmol/L REGENSTRIEF

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53708-4