5381-9

Thyroglobulin Ab [Titer] in Serum by Latex agglutination

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Part Descriptions

LP14697-4   Thyroglobulin
Thyroglobulin (Tg) is a protein produced by and used entirely within the thyroid gland. Thyroglobulin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is stored in the thyroid in follicle cysts surrounded by colloid cells. Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Thyroxine is produced by linking two moieties of DIT. Combining one particle of MIT and one particle of DIT produces triiodothyronine. Proteases in lysosomes digest iodinated thyroglobulin, releasing T3 and T4. Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin levels in the blood can also be elevated in cases of Graves Disease. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Thyroglobulin (Wikipedia)

LP14697-4   Thyroglobulin
Thyroglobulin (Tg) is a glycoprotein homodimer produced by the thyroid gland. It is important in the synthesis of thyroxine and triiodothyronine, and is where the inactive forms of thyroid hormone and iodine are stored. Mutations in the Tg gene cause thyroid dyshormonogenesis resulting in goiter, and can be associated with moderate to severe congenital hypothyroidism. Polymorphisms in the Tg gene are associated with susceptibility to autoimmune thyroid diseases such as Graves disease or Hashimoto thyroiditis. [NCBI Gene ID:7038] Tg is an established tumor marker used in the diagnosis of differentiated thyroid carcinoma. PMID: 9543128 Source: Regenstrief LOINC

LP39996-1   Thyroglobulin Ab
Circulating immunoglobulins directed against thyroglobulin are commonly present in patients with autoimmune (Hashimoto) thyroiditis and, to a lesser extent, Graves disease. Thyroglobulin is a 660-kd protein precursor of thyroid hormones. Thyroglobulin antibodies are present in the sera of approximately 70% of patients with autoimmune thyroiditis. The principal use of the test is to confirm that a patient's diffuse goiter and/or hypothyroidism is due to autoimmune thyroiditis. The test may also help distinguish Graves disease from toxic nodular goiter. Although thyroglobulin antibodies are present less often than thyroid microsomal antibodies (eg, thyroid peroxidase antibodies, anti-TPO) in patients with autoimmune thyroid diseases, screening fro both immunoglobulins increases diagnostic sensitivity. Thyroglobulin antibodies may be detected in individuals without clinically significant thyroid disease. They do not define the patient's thyroid functional status. Source: Quest Diagnostics Inc., Thyroglobulin antibodies

Reference Information

Fully-Specified Name

Component

Thyroglobulin Ab

Property

Titr

Time

Pt

System

Ser

Scale

SemiQn

Method

LA

Additional Names

Short Name

Thyroglob Ab Titr Ser LA

Display Name

Thyroglobulin Ab LA (S) [Titer]

Consumer Name Alpha Get Info

Thyroglobulin antibody, Blood

Basic Attributes

Class

SERO

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.75

Order vs. Observation

Both

Common Test Rank Get Info

16347

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Antithyroglob
• Autoantibodies
• Autoantibody
• Dilution factor
• Dilution Factor (Titer)
• Endocrine
• Endocrinology
• Hashimoto's thyroiditis
• LAT
• Latex agglutination
• Point in time
• Random
• Serology
• Serum
• SmQn
• SR
• Tg
• TgAbs
• Thyglobulin
• Thyroglbn
• Thyroglob
• Titer
• Titered
• Titre
• Ttr
• Tumor marker
• UniversalLabOrders

Example Units

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.