54447-8
FLT3 gene targeted mutation analysis in Bone marrow by Molecular genetics method
Active
Part Description
LP61778-4 FLT3 gene
The FLT3 gene (fms-related tyrosine kinase 3) [HGNC Gene ID:3765] is located on chromosome 13q12. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] [NCBI Gene ID:2322] FLT3 mutations occur in approximately 1/3 of patients with AML. About 70% are internal tandem duplications, and the rest are due to variants in the tyrosine kinase domain of FLT3, primarily at Asp835 (D835). PMID: 17124058
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- FLT3 gene targeted mutation analysis
- Property
- Find
- Time
- Pt
- System
- Bone mar
- Scale
- Doc
- Method
- Molgen
Additional Names
- Short Name
- FLT3 gene Mut Anl Mar
- Display Name
- FLT3 gene targeted mutation analysis Molgen Doc (BM)
- Consumer Name Alpha Get Info
- FLT3 gene targeted mutation analysis, Bone marrow
Basic Attributes
- Class
- MOLPATH.MUT
- Type
- Laboratory
- First Released
- Version 2.27
- Last Updated
- Version 2.73
- Change Reason
- Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.; Based on LOINC Committee review (June 2019), updated the Property from "Prid" to "Find" and Scale from "Nar" to "Doc" to align with the current LOINC model for naming collections of information reported in narrative and/or structured formats.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 17255
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Gen FLT3 Analisis de mutaciones: |
| es-MX | Spanish (Mexico) | Análisis de mutaciones dirigidas al gen FLT3: |
| fr-FR | French (France) | FLT3 gène mutation cible trouvée: |
| it-IT | Italian (Italy) | FLT3, gene analisi di mutazione mirata: Synonyms: Gene FLT3 Genetica molecolare Midollo osseo Mutazione genica Osservazione Patologia molecolare Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | FLT3-gen doelgerichte mutatie-analyse: Synonyms: FLT3 gen molgen targeted |
| pt-BR | Portuguese (Brazil) | FLT3 análise de mutação do gene: Synonyms: FLK2; |
| ru-RU | Russian (Russian Federation) | FLT3 ген исследование на мутацию: Synonyms: Документ Точка во времени; |
| tr-TR | Turkish (Turkey) | FLT3 geni Mutasyon analizi: |
| zh-CN | Chinese (China) | FLT3 基因 突变分析: Synonyms: FL 细胞因子受体前体; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=54447-8
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright