30894-0 Aldosterone/Renin [Ratio] in Plasma

Part Descriptions

LP14377-3   Aldosterone
Aldosterone is a steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Acting on mineralocorticoid receptors (MR) on principal cells in the collecting ducts of the kidneys, it increases the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. Aldosterone also stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3-) levels and its acidbase balance. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Aldosterone (Wikipedia)

LP14377-3   Aldosterone
Used to detect hyper and hypo aldosteronisnm. Hypoaldosteronism can occur in any condition that causes destruction or dysfunction of the adrenal gland.1,2,4 Hypoaldosterism can be due to primary adrenal insufficiency , congenital adrenal hypoplasia, acquired secondary aldosterone deficiency (hyporeninemic hypoaldosteronism), and acquired Hyporeninemic hypoaldosteronism is the most common form of isolated hypoaldosteronism and is results from impaired renin release from the kidney. Congenital hypoaldosteronism caused by inherited enzymatic defects in aldosterone biosynthesis are rare. Corticosterone methyloxidase I (CMO I) deficiency is associated with elevated serum levels of corticosterone and low levels of 18-hydroxy-corticosterone and aldosterone. Corticosterone methyloxidase II (CMO II) deficiency produces high levels of 18-hydroxy-corticosterone, the immediate precursor of aldosterone.
Acquired primary hypoaldosteronism can be caused by the administration of heparin. Also, persistently hypotensive, critically ill patients with sepsis, pneumonia, peritonitis, cholangitis, and liver failure can have inappropriately low plasma aldosterone concentrations in relation to elevated plasma renin activity. Primary hyperaldosteronism, also referred to as Conn syndrome, is due to overproduction of aldosterone by one or both of the adrenal glands. Some recent studies suggest that 10% to 15% of Hyper thyroidism cases are due to (or associated with ) primary hyperaldosteronism. Secondary hyperaldosteronism is relatively common and can occur as the result of any condition that decreases blood flow to the kidneys (ie, renal artery stenosis), decreases blood pressure, or lowers plasma sodium levels. Secondary hyperaldosteronism may also be seen with cirrhosis, congestive heart failure. and toxemia of pregnancy. Several studies have suggested that high-normal aldosterone levels predict development of high blood pressure in normotensive subjects and that increased aldosterone action contributes to hypertension, cardiovascular fibrosis, and cardiac hypertrophy. Source: Regenstrief Institute

LP32149-4   Renin
Molecular structure of renin Symbol(s):REN Other names: Angiotensinogenase Genetic data Locus:Chr. 1 q32 Protein StructureFunction Protein length: 406 (Amino Acids) Molecular Weight: 45060 (Da) Functions: Converts angiotensinogen to angiotensin I Motifs: SP motif Alternative Products: 2 known isoforms produced from alternative splicing Other Taxa expressing:Homo sapiens ; homologs many metazoan taxa Subcellular localization: Extracellular Biophysicochemical properties: K M =1 µmolL for angiotensinogen Database Links EC number:3.4.23.15 Codes: EntrezGene 5972 ; Mendelian Inheritance in Man [OMIM: 179820] ; RefSeq NM_000537 ; [UniProt: P00797] Renin, also known as angiotensinogenase, is a circulating enzyme released mainly by juxtaglomerular cells in the JGA of the kidneys in response to low blood volume or low body NaCl content, mediated through the rapid release of prostaglandins. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Renin (Wikipedia)

LP32149-4   Renin
An enzyme which is secreted by the KIDNEY and is formed from prorenin in plasma and kidney. The enzyme cleaves the Leu-Leu bond in ANGIOTENSINOGEN to generate ANGIOTENSIN I. This enzyme was formerly listed as EC 3.4.99.19. Source: National Library of Medicine, MeSH 2006

Fully-Specified Name

Component

Aldosterone/Renin

Property

Ratio

Time

Pt

System

Plas

Scale

Qn

Method

Additional Names

Short Name

Aldost/Renin Plas-Rto

Display Name

Aldosterone/Renin (P) [Ratio]

Consumer Name Alpha Get Info

Aldosterone/Renin, Blood

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.04

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

2016

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Angiotensin forming enzyme
• Angiotensinogenase
• Chemistry
• Endocrine
• Endocrinology
• Pl
• Plasma
• Plsm
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Ratios
• Rto

Example Units

1763-2 Aldosterone [Mass/volume] in Serum or Plasma

Part Descriptions

LP14377-3   Aldosterone
Aldosterone is a steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Acting on mineralocorticoid receptors (MR) on principal cells in the collecting ducts of the kidneys, it increases the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. Aldosterone also stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3-) levels and its acidbase balance. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Aldosterone (Wikipedia)

LP14377-3   Aldosterone
Used to detect hyper and hypo aldosteronisnm. Hypoaldosteronism can occur in any condition that causes destruction or dysfunction of the adrenal gland.1,2,4 Hypoaldosterism can be due to primary adrenal insufficiency , congenital adrenal hypoplasia, acquired secondary aldosterone deficiency (hyporeninemic hypoaldosteronism), and acquired Hyporeninemic hypoaldosteronism is the most common form of isolated hypoaldosteronism and is results from impaired renin release from the kidney. Congenital hypoaldosteronism caused by inherited enzymatic defects in aldosterone biosynthesis are rare. Corticosterone methyloxidase I (CMO I) deficiency is associated with elevated serum levels of corticosterone and low levels of 18-hydroxy-corticosterone and aldosterone. Corticosterone methyloxidase II (CMO II) deficiency produces high levels of 18-hydroxy-corticosterone, the immediate precursor of aldosterone.
Acquired primary hypoaldosteronism can be caused by the administration of heparin. Also, persistently hypotensive, critically ill patients with sepsis, pneumonia, peritonitis, cholangitis, and liver failure can have inappropriately low plasma aldosterone concentrations in relation to elevated plasma renin activity. Primary hyperaldosteronism, also referred to as Conn syndrome, is due to overproduction of aldosterone by one or both of the adrenal glands. Some recent studies suggest that 10% to 15% of Hyper thyroidism cases are due to (or associated with ) primary hyperaldosteronism. Secondary hyperaldosteronism is relatively common and can occur as the result of any condition that decreases blood flow to the kidneys (ie, renal artery stenosis), decreases blood pressure, or lowers plasma sodium levels. Secondary hyperaldosteronism may also be seen with cirrhosis, congestive heart failure. and toxemia of pregnancy. Several studies have suggested that high-normal aldosterone levels predict development of high blood pressure in normotensive subjects and that increased aldosterone action contributes to hypertension, cardiovascular fibrosis, and cardiac hypertrophy. Source: Regenstrief Institute

Fully-Specified Name

Component

Aldosterone

Property

MCnc

Time

Pt

System

Ser/Plas

Scale

Qn

Method

Additional Names

Short Name

Aldost SerPl-mCnc

Display Name

Aldosterone [Mass/Vol]

Consumer Name Alpha Get Info

Aldosterone, Blood

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

1005

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Chemistry
• Endocrine
• Endocrinology
• Level
• Mass concentration
• Pl
• Plasma
• Plsm
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR
• UniversalLabOrders

Example Units

2915-7 Renin [Enzymatic activity/volume] in Plasma

Part Descriptions

LP15273-3   Renin
The renal juxtaglomerular apparatus generates renin, an enzyme that converts angiotensinogen to angiotensin I. Angiotensinogen, derived from the liver, is an alpha-2-globulin. The inactive angiotensin I is enzymatically converted to the active octapeptide angiotensin II, which is a potent vasopressor responsible for hypertension of renal orgin. Renin activity is elevated in renal vascular diseases and suppressed in primary hyperaldosteronism. Renin activity is affected by diuretics and low sodium stimulates activity. Source: Regenstrief Institute

Fully-Specified Name

Component

Renin

Property

CCnc

Time

Pt

System

Plas

Scale

Qn

Method

Additional Names

Short Name

Renin Plas-cCnc

Display Name

Renin (P) [Catalytic activity/Vol]

Consumer Name Alpha Get Info

Renin, Blood

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

1136

Member of these Panels

Language Variants Get Info

Related Names

• Active renin
• Angiotensin forming enzyme
• Angiotensinogenase
• Cardio
• Cardiology
• Catalytic Concentration
• Chemistry
• Endocrine
• Endocrinology
• Heart Disease
• Kidney
• Nephrology
• Pl
• Plasma
• Plasma renin activity
• Plsm
• Point in time
• PRA
• QNT
• Quan
• Quant
• Quantitative
• Random
• Renal
• UniversalLabOrders

Example Units