Version 2.80

Status Information

Status
DEPRECATED
Comment
Based on extensive review of mappings and usage across Canada, Canada Health Infoway found that the limited use LABORDER codes are not being used. CHI and the Laboratory LOINC Committee agreed that these codes should be deprecated in order to minimize inadvertent mapping of observations to these terms (as has been reported).
Map-To Long Common Name Mapping Guidance
41995-2 Hemoglobin A1c [Mass/volume] in Blood

Term Description

Created ONLY for ORDERING in response to request from Canada Health Infoway- a national standardization effort. The dashes in this case mean that the ordering provider does not care what property or scale is used in the observation performed in response to this order. LOINC is still pondering details about how this kind of item should be represented. So the representation might change in the future, but the term will still have the same usage and meaning.

Part Description

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Fully-Specified Name

Component
Hemoglobin A1c
Property
-
Time
Pt
System
Bld
Scale
-
Method

Additional Names

Long Common Name
Deprecated Hemoglobin A1c in Blood
Short Name
Deprecated Hgb A1c Bld
Display Name
HbA1c (Bld)
Consumer Name Alpha Get Info
HbA1c, Blood

Basic Attributes

Class
LABORDERS
Type
Laboratory
First Released
Version 2.27
Last Updated
Version 2.66 (DEL)
Order vs. Observation
Order

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Αιμοσφαιρίνη A1c:-:Pt:Αίμα:-:
Synonyms: Αιμοσφαιρίνη Αιμοσφαιρίνη A1c
es-ES Spanish (Spain) Hemoglobina A1c (Hemoglobina glicosilada):Propiedades mixtas (sólo paneles):Punto temporal:Sangre:-:
es-MX Spanish (Mexico) Hemoglobina a1c:-:Punto temporal:Sangre:-:
et-EE Estonian (Estonia) Hemoglobiin A1c:-:Pt:B:-:
Synonyms: Glükohemoglobiin Juhuslik Veri
fr-CA French (Canada) Hémoglobine A1c:-:Temps ponctuel:Sang:-:
fr-FR French (France) Hémoglobine A1c:-:Ponctuel:Sang:-:
fr-BE French (Belgium) Hémoglobine A1c:-:Temps ponctuel:Sang:-:
Synonyms: Demande de laboratoire, prescription analyses labo Hb HbA1c
it-IT Italian (Italy) Emoglobina A1c:-:Pt:Sangue:-:
Synonyms: Codici richieste di laboratorio Emoglobina A1c (HgB glicata ) Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) hemoglobine A1c:-:moment:bloed:-:
pl-PL Polish (Poland) Hemoglobina A1c:-:punkt w czasie:krew:-:
pt-BR Portuguese (Brazil) Hemoglobina A1c:#N/A:Pt:SgTotal:-:
Synonyms: ; Hgb A1c; Glycohemogolobin; Glycohaemogolobin; GHb; HA1c; HBA1c; Glycated hemoglobin; Glycosylated hemoglobin; Hb; Haemoglobin; Point in time; Random; Blood; WB; Whole blood; LAc orders
ru-RU Russian (Russian Federation) Гемоглобин А1с:-:ТчкВрм:Кр:-:
Synonyms: Кровь Точка во времени;Момент
zh-CN Chinese (China) 血红蛋白 A1c:-:时间点:全血:-:
Synonyms: GHb;HA1c;HBA1c;Hgb A1c;糖化血红蛋白;糖基化血红蛋白;血红蛋白 A1c （糖化血红蛋白） 多重;多重型;多重标尺类型;多重精度类型 实验室检验项目医嘱类;检验项目医嘱;检验项目申请;化验项目申请 时刻;随机;随意;瞬间 氧血红蛋白;血红朊;血红素;血色素 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=55454-3