55783-5

Hemoglobin Barts [Presence] in Blood by HPLC

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Part Description

LP16418-3   Hemoglobin Barts
Hemoglobin Barts is a relatively common hemoglobin variant consisting of four gamma chains. Hemoglobin Barts is an extremely high affinity hemoglobin that is not effective at delivering oxygen to tissues. Hemoglobin Barts is only seen during the newborn period and usually indicates that one or more of the baby's alpha-globin genes are deleted, resulting in alpha-thalassemia. Alpha thalassemia is caused by deletions of the alpha globin genes on chromosome 16. Normal patients have four copies of the alpha-globin gene, 2 on each chromosome. A silent carrier will have one deleted alpha gene and usually result in a benign condition. Alpha thalassmia trait occurs when there are two deleted alpha genes, resulting in mild or no anemia with microcytosis and hypochromia. Hemoglobin H disease results from the deletion of three alpha genes with resultant moderately severe alpha thalassemia. Most patients are anemic and display some degree of splenomegaly. Fetal hydrops syndrome occurs when all four alpha genes are deleted. Fetal hydrops is not compatible with life and death occurs in utero or during early infancy.Carrier states for alpha thalassemia are very common in the African, Meditteranean and Asian populations. In general, only the loss of one or two genes is seen in African Americans. Asian and Meditteranean populations may have all types of alpha thalassemia. Information from The Georgia Comphensive Sickle Cell Center at Grady Health System, Emory University School of Medicine Department of Pediatrics, Atlanta, GA at www.scinfo.org, accessed 2007 11 02, and The Utah Department of Health at www.health.utah.gov, accessed 2007 11 02. Source: Regenstrief Institute

Fully-Specified Name

Component

Hemoglobin Barts

Property

PrThr

Time

Pt

System

Bld

Scale

Ord

Method

HPLC

Additional Names

Short Name

Hgb Barts Bld Ql HPLC

Display Name

Hemoglobin Barts HPLC Ql (Bld)

Consumer Name Alpha Get Info

Hemoglobin barts, Blood

Basic Attributes

Class

HEM/BC

Type

Laboratory

First Released

Version 2.29

Last Updated

Version 2.56

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Observation

Member of these Panels

Language Variants Get Info

Related Names

• Bart
• Bart's
• Blood
• Haemoglobin
• Hb
• HEMATOLOGY/CELL COUNTS
• Hgb
• Hgb Barts
• High performance liquid chromatography
• High pressure liquid chromatography
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• WB
• Whole blood

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=55783-5

LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.