56536-6
Thyroglobulin Ab [Units/volume] in Serum or Plasma by Immunoassay
Active
Part Descriptions
LP14697-4 Thyroglobulin
Thyroglobulin (Tg) is a protein produced by and used entirely within the thyroid gland. Thyroglobulin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is stored in the thyroid in follicle cysts surrounded by colloid cells. Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Thyroxine is produced by linking two moieties of DIT. Combining one particle of MIT and one particle of DIT produces triiodothyronine. Proteases in lysosomes digest iodinated thyroglobulin, releasing T3 and T4. Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin levels in the blood can also be elevated in cases of Graves Disease.
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Source: Wikipedia, Thyroglobulin (Wikipedia)
LP14697-4 Thyroglobulin
Thyroglobulin (Tg) is a glycoprotein homodimer produced by the thyroid gland. It is important in the synthesis of thyroxine and triiodothyronine, and is where the inactive forms of thyroid hormone and iodine are stored. Mutations in the Tg gene cause thyroid dyshormonogenesis resulting in goiter, and can be associated with moderate to severe congenital hypothyroidism. Polymorphisms in the Tg gene are associated with susceptibility to autoimmune thyroid diseases such as Graves disease or Hashimoto thyroiditis. [NCBI Gene ID:7038] Tg is an established tumor marker used in the diagnosis of differentiated thyroid carcinoma. PMID: 9543128
Source: Regenstrief LOINC
LP39996-1 Thyroglobulin Ab
Circulating immunoglobulins directed against thyroglobulin are commonly present in patients with autoimmune (Hashimoto) thyroiditis and, to a lesser extent, Graves disease. Thyroglobulin is a 660-kd protein precursor of thyroid hormones. Thyroglobulin antibodies are present in the sera of approximately 70% of patients with autoimmune thyroiditis. The principal use of the test is to confirm that a patient's diffuse goiter and/or hypothyroidism is due to autoimmune thyroiditis. The test may also help distinguish Graves disease from toxic nodular goiter. Although thyroglobulin antibodies are present less often than thyroid microsomal antibodies (eg, thyroid peroxidase antibodies, anti-TPO) in patients with autoimmune thyroid diseases, screening fro both immunoglobulins increases diagnostic sensitivity. Thyroglobulin antibodies may be detected in individuals without clinically significant thyroid disease. They do not define the patient's thyroid functional status.
Source: Quest Diagnostics Inc., Thyroglobulin antibodies
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. | Thyroid Antibodies |
Fully-Specified Name
- Component
- Thyroglobulin Ab
- Property
- ACnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
- IA
Additional Names
- Short Name
- Thyroglob Ab SerPl IA-aCnc
- Display Name
- Thyroglobulin Ab IA Qn
- Consumer Name Alpha Get Info
- Thyroglobulin antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.29
- Last Updated
- Version 2.73
- Change Reason
- The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 1193
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG21864-0 | Thyroglobulin Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Thyreoglobulin Ak: Synonyms: hTG |
| el-GR | Greek (Greece) | Θυρεοσφαιρίνη Αντίσωμα: Synonyms: Ab |
| es-ES | Spanish (Spain) | Tiroglobulina Anticuerpos: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Tiroglobulina Ab: |
| et-EE | Estonian (Estonia) | Türeoglobuliin antikehad: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-CA | French (Canada) | Thyroglobuline , Ac: |
| fr-FR | French (France) | Thyroglobuline anticorps: |
| fr-BE | French (Belgium) | Thyroglobuline Ac: Synonyms: Anticorps hTG |
| it-IT | Italian (Italy) | Tireoglobulina Ab: Synonyms: anticorpo Concentrazione Arbitraria Immunoassay Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | thyreoglobuline As: Synonyms: antistof; |
| pt-BR | Portuguese (Brazil) | Tireoglobulina Ac: Synonyms: AntiTiroglob; |
| ru-RU | Russian (Russian Federation) | Тиреоглобулин Ат: Synonyms: Антитело Количественный Плазма Произвольная концентрация Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Tiroglobulin Ab: Synonyms: Ak İmmünölçüm, immünoassay |
| uk-UA | Ukrainian (Ukraine) | Тиреоглобулін Антитіла: Synonyms: ABS; |
| zh-CN | Chinese (China) | 甲状腺球蛋白 抗体: Synonyms: Ab; |
Example Units
| Unit | Source |
|---|---|
| [arb'U]/mL | Example UCUM Units |
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