Version 2.77

Part Description

LP18489-2   Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. PMID: 7532143 GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located. PMID: 22412264 Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases. PMID: 22405456 Source: Regenstrief LOINC

Fully-Specified Name

Component
Glutamate decarboxylase 65 Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method
IA

Additional Names

Short Name
GAD65 Ab Ser IA-aCnc
Display Name
Glutamate decarboxylase 65 Ab IA Qn (S)
Consumer Name Alpha Get Info
Glutamate decarboxylase 65 antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.29
Last Updated
Version 2.73
Change Reason
The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
3523

Member of these Groups Get Info

LOINC Group Group Name
LG2003-4 Glutamate decarboxylase 65 Ab|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Glutamat-Decarboxylase 65 Ak:Arbiträre Konzentration:Zeitpunkt:Serum:Quantitativ:Immunoassay
es-ES Spanish (Spain) Glutamato decarboxilasa 65 Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Glutamato descarboxilasa 65 Ab:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Inmunoensayo
et-EE Estonian (Estonia) Glutamaadi dekarboksülaasi 65 vastased antikehad:Acnc:Pt:S:Qn:IA
Synonyms: Juhuslik Kvantitatiivne Seerum
fr-CA French (Canada) Glutamate décarboxylase 65 , Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:IA
fr-FR French (France) Glutamate décarboxylase 65 anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Immunoanalyse
fr-BE French (Belgium) Glutamate décarboxylase 65 Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:IA
Synonyms: Anticorps
it-IT Italian (Italy) Glutammato decarbossilasi 65 Ab:ACnc:Pt:Siero:Qn:IA
Synonyms: anticorpo Concentrazione Arbitraria GAD65 Immunoassay Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) glutamaatdecarboxylase 65 As:eenheid/volume:moment:serum:kwantitatief:immunoassay
Synonyms: antistof; antilichaam IA
pt-BR Portuguese (Brazil) Glutamato descarboxilase 65 Ac:#N/A:Pt:Soro:Qn:Imunoensaio
Synonyms: GADA; GAD65; GAD-65; Glutamic acid decarboxylase-65; Glu; Arbitrary concentration; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Enzyme immunoassay; ELISA; MEIA; SUDS; ELFA; IAA; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU Russian (Russian Federation) Глутаматдекарбоксилаза 65 Ат:ПроизвКонц:ТчкВрм:Сыв:Колич:IA
Synonyms: Антитело Количественный Произвольная концентрация Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) Glutamat dekarboksilaz 65 Ab:SçKons:Zmlı:Ser:Kant:İA
Synonyms: Ak İmmünölçüm, immünoassay
uk-UA Ukrainian (Ukraine) Глутамат декарбоксилаза 65 Антитіла:Довільна Концентрація:МоментЧасу:Сироватка:Кількісно:Імуноаналіз
Synonyms: ABS; Aby; Antby; Anti; Antibodies; Antibody; Arbitrary concentration; Autoantibodies; Autoantibody; Autoimmune myelopathy; c707; EIA; ELFA; ELISA; Endocrine; Endocrinology; Enzyme immunoassay; GAD; GAD65; GAD-65; GADA; Glu; Glutamic acid; Glutamic acid decarboxylase-65; IAA; Insulin-Dependent Diabetes Mellitus; MEIA; Paraneoplastic neurological syndrome; Point in time; QNT; Quan; Quant; Quantitative; Random; Serology; Serum; SR; SUDS; UniversalLabOrders
zh-CN Chinese (China) 谷氨酸脱羧酶-65 抗体:任意型浓度:时间点:血清:定量型:免疫测定法
Synonyms: Ab;自身抗体 GAD65;GAD-65;谷氨酸脱羧酶 65;谷氨酸脱羧酶 65（Glutamate Decarboxylase 65，GAD65，Glutamic acid decarboxylase-65，GAD-65） GADA Glu 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 谷氨酸脱羧酶 65 Ab 谷氨酸脱羧酶 65 抗体 谷氨酸脱羧酶-65 Ab 麸胺酸去羧酶;麸胺酸去羧基酶;麸氨酸去羧基酶;GAD

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=56540-8