57565-4

21-Deoxycortisol [Moles/volume] in Serum or Plasma --2 days post dose dexamethasone

Active

Part Description

LP65144-5 21-Deoxycortisol
Plasma 21-deoxycortisol (21DF) is an excellent marker of 21-hydroxylase deficiency. Currently, it is the only marker able to detect heterozygous carriers with 21-hydroxylase deficiency after Adrenocorticotropic Hormone (ACTH) stimulation. The syndrome of congenital adrenal hyperplasia (CAH) comprises the spectrum of autosomal recessive enzymatic disorders that impair cortisol biosynthesis. The hormonal pattern and clinical manifestations result from hyperstimulation of the adrenal cortex by excessive production of ACTH, untied from the negative feedback exerted by reduced cortisol levels, and the ultimate accumulation of F precursors and androgens. These abnormalities predispose the female newborn to ambiguous genitalia (female pseudohermaphroditism) and precocious puberty that may occur in both sexes. CAH due to 21-hydroxylase deficiency (21OHD) comprises nearly 90% of all cases, with an estimated worldwide incidence of 1 in 14,000 live births. Because 21-deoxycortisol (21DF) is an 11b-hydroxylase (11bOH) derivative of 17-hydroxyprogesterone (17OHP), its serum levels are parallel and proportionally elevated in patients with 21OHD but decreased or undetectable in those with 11b-hydroxylase deficiency (11bOHD). Due to the marked buildup of 17OHP in 21OHD, this precursor steroid can proceed directly to 11-hydroxylation, producing distinct elevations of 21DF. PMID: 16551734, PMID: 10731638 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database , 21-Deoxycortisol

Fully-Specified Name

Component: 21-Deoxycortisol^2D post dose dexamethasone
Property: SCnc
Time: Pt
System: Ser/Plas
Scale: Qn
Method

Additional Names

Long Common Name: 21-Deoxycortisol [Moles/volume] in Serum or Plasma --2 days post dose dexamethasone
Short Name: 21DC 2D p Dex SerPl-sCnc
Display Name: 21-Deoxycortisol 2 days post dose dexamethasone [Moles/Vol]
Consumer Name Alpha Get Info: 21-Deoxycortisol 2 days after dexamethasone, Blood

Basic Attributes

Class: CHAL
Type: Laboratory
First Released: Version 2.29
Last Updated: Version 2.70 (MIN)
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	21-δεοξυκορτιζόλη^2 ημέρες κατόπιν δόσης δεξαμεθαζόνης:SCnc:Pt:Ορός/Πλάσμα:Qn: Synonyms: 21-δεοξυκορτιζόλη SCnc Δεξαμεθαζόνη
es-ES	Spanish (Spain)	21-Deoxicortisol^2D pos dosis de dexametasona:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	21-Deoxicortisol^2D posdosis dexametasona:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
fr-CA	French (Canada)	21-désoxycortisol^2 j post dose dexaméthasone:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR	French (France)	21-déoxycortisol TJ02 après dexaméthasone:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE	French (Belgium)	21-déoxycortisol^2 j post dose dexaméthasone:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT	Italian (Italy)	21-Deossicortisolo^2 gg post dose desametazone:SCnc:Pt:Siero/Plasma:Qn: Synonyms: 2 giorni dopo soppressione con desametazone;2die p Concentrazione di Sostanza dopo dose dopo dose di desametasone Plasma Punto nel tempo (episodio) Siero Siero o Plasma Test di provocazione
nl-NL	Dutch (Netherlands)	21-deoxycortisol^2 dagen na dosis dexamethason:mol/volume:moment:serum of plasma:kwantitatief: Synonyms: 2D na dosis dexamethason
pt-BR	Portuguese (Brazil)	21-Deoxicortisol^2 dias após dose de dexametasona:#N/A:Pt:Sor/Plas:Qn: Synonyms: Decadron; Dexameth; Dexone; Hexadrol; 21DC; 2D p Dex; p dose; Substance concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; PST; After; CHEMISTRY.CHALLENGE TESTING; CHEMISTRY.CHALLENGE TESTING
ru-RU	Russian (Russian Federation)	21-Дезоксикортизол^2 дня после дозы дексаметазона:МолКонц:ТчкВрм:Сыв/Плаз:Колич: Synonyms: Количественный Молярность;Молярная объёмная концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	21-Deoksikortizol^2G snr dekzametazon dozu:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CN	Chinese (China)	21-脱氧皮质醇^在给予剂量地塞米松之后2天:物质的量浓度:时间点:血清/血浆:定量型: Synonyms: 21DC;21-脱氧可的索;21-脱氧氢化可的松;21-脱氧皮质甾醇;21-脱氧考的索 2D之后于给予一剂地塞米松;2D之后于给予剂量地塞米松;2天之后于给予一剂地塞米松;2天之后于给予剂量地塞米松;48Hr之后于给予一剂地塞米松;48Hr之后于给予剂量地塞米松;48小时之后于给予一剂地塞米松;48小时之后于给予剂量地塞米松;在给予一剂地塞米松之后2D;在给予一剂地塞米松之后2天;在给予一剂地塞米松之后48Hr;在给予一剂地塞米松之后48小时;在给予剂量地塞米松之后2D;在给予剂量地塞米松之后48Hr;在给予剂量地塞米松之后48小时 9α氟16甲基脱氢皮质甾醇;氟甲强的松龙;氟美松;甲氟烯索 XXX刺激 - 在...之后一剂物质一剂药物之后于... 之后于剂量物质;之后于剂量药物;在剂量物质之后之后于给予地塞米松克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 剂量物质可用数量表示的;定量性;数值型;数量型;连续数值型标尺在...以后在后时刻;随机;随意;瞬间血清或血浆

Example Units

Unit	Source
nmol/L	Example UCUM Units

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