Version 2.80

Part Descriptions

LP16902-6   Platelet factor 4
A high-molecular-weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin. It acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation. At high ionic strength (I=0.75), the complex dissociates into the active component (molecular weight 29,000) and the proteoglycan carrier (chondroitin 4-sulfate, molecular weight 350,000). The molecule exists in the form of a dimer consisting of 8 moles of platelet factor 4 and 2 moles of proteoglycan. Source: National Library of Medicine, MeSH 2006

LP16902-6   Platelet factor 4
Platelet factor-4 (PF4) is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major role is to neutralize heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 may play a role in inflammation and wound repair. The heparin:PF4 complex is the immunogen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction that sometimes occurs following the injection of heparin. PF4 autoantibodies have also been observed in patients with thrombosis and features resembling HIT although these patients did not receive heparin. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Wikipedia

Reference Information

Type Source Reference
Mapping Guidance Regenstrief Help PF4 is used clinically to assess degree of platelet activation but specimen has to be collected meticulously. Some labs use PD4 as short hand for Heparin induced platelet Ab so be careful about mapping. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

Fully-Specified Name

Component
Platelet factor 4
Property
ACnc
Time
Pt
System
PPP
Scale
Qn
Method

Additional Names

Long Common Name
Platelet factor 4 [Units/volume] in Platelet poor plasma
Short Name
PF4 PPP-aCnc
Display Name
Platelet factor 4 Qn (PPP)
Consumer Name Alpha Get Info
Platelet factor 4, Blood

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 1.0d
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
6974

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Thrombozytenfaktor 4:Arbiträre Konzentration:Zeitpunkt:Thrombozytenarmes Plasma:Quantitativ:
el-GR Greek (Greece) Παράγοντας αιμοπεταλίων 4:ACnc:Pt:PPP:Qn:
Synonyms: ACnc Αιμοπετάλιο Παράγοντας αιμοπεταλίων 4
es-AR Spanish (Argentina) factor 4 plaquetario:concentración arbitraria:punto en el tiempo:plasma desplaquetado:cuantitativo:
es-MX Spanish (Mexico) Factor plaquetario 4:Concentración arbitraria:Punto temporal:Plasma pobre en plaquetas:Cuantitativo:
es-ES Spanish (Spain) Factor plaquetario 4:Concentración arbitraria:Punto temporal:Plasma pobre en plaquetas:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Trombotsüütide 4. faktor:Acnc:Pt:PPP:Qn:
Synonyms: Juhuslik Kvantitatiivne Trombotsüütidevaene plasma
fr-FR French (France) Facteur 4 plaquettaire:Arbitraire/Volume:Ponctuel:Plasma pauvre en plaquettes:Numérique:
fr-BE French (Belgium) Facteur 4 plaquettaire:Concentration arbitraire:Temps ponctuel:Plasma pauvre en plaquettes:Quantitatif:
Synonyms: PF4
fr-CA French (Canada) Facteur 4 plaquettaire:Concentration arbitraire:Temps ponctuel:Plasma pauvre en plaquettes:Quantitatif:
it-IT Italian (Italy) Fattore piastrinico 4:ACnc:Pt:PPP:Qn:
Synonyms: Concentrazione Arbitraria Piastrine Plasma povero di piastrine Punto nel tempo (episodio) Studio di coagulazione
ko-KR Korean (Korea, Republic Of) 혈소판 제4 인자:임의농도:검사시점:혈소판제거혈장:정량:
nl-NL Dutch (Netherlands) plaatjes factor 4:eenheid/volume:moment:plaatjesarm plasma:kwantitatief:
Synonyms: coagulatiemethode
pl-PL Polish (Poland) Czynnik płytkowy 4:stężenie w jednostkach umownych:punkt w czasie:osocze ubogopłytkowe:ilościowy:
Synonyms: Czynnik płytkowy PPP
pt-BR Portuguese (Brazil) Fator plaquetário 4:ACnc:Pt:PPPQ:Qn:
Synonyms: ; PF4; Heparin-Induced Platelet Ac; PI-factor 4; Platelet type heparin inactivator; PF; Plt; Pl; Platelets; Thrombocytes; Platelt; Thrombocyte; Arbitrary concentration; Point in time; Random; Platelet poor plasma; Plas; Quantitative; QNT; Quant; Quan; Fac; Fact; COAGULATION
ru-RU Russian (Russian Federation) Пластинка фактор 4:ПроизвКонц:ТчкВрм:ОПП:Колич:
Synonyms: Количественный Обеднённая пластинками плазма;Бедная тромбоцитами плазма Произвольная концентрация Точка во времени;Момент Тромбоцит Тромбоцитарный фактор 4
tr-TR Turkish (Turkey) Trombosit faktör 4:SçKons:Zmlı:TFkP:Kant:
zh-CN Chinese (China) 血小板因子 4:任意型浓度:时间点:贫血小板血浆:定量型:
Synonyms: PF4;PI-因子 4;肝素诱导型血小板 AB（Heparin-Induced Platelet AB）;血小板因子 4（Platelet factor 4，PF4）;血小板型肝素灭活剂（Platelet type heparin inactivator） 乏血小板血浆;Platelet poor plasma;PPP 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 因素 时刻;随机;随意;瞬间 系数 血栓细胞

Example Units

Unit Source
OD units REGENSTRIEF
{OD_unit} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=6002-0