Version 2.78

Part Descriptions

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, D-lactate (Wikipedia)

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC 1.1.1.27) and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. PMID: 3882046. Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition] Source: Regenstrief LOINC

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. Lactate Dehydrogenase (LD)

Fully-Specified Name

Component
Lactate dehydrogenase
Property
CCnc
Time
Pt
System
CSF
Scale
Qn
Method
Reaction: pyruvate to lactate

Additional Names

Short Name
LDH CSF P to L-cCnc
Display Name
LDH Pyruvate to lactate reaction (CSF) [Catalytic activity/Vol]
Consumer Name Alpha Get Info
Lactate Dehydrogenase (LDH), Spinal fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.34
Last Updated
Version 2.70
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Lactatdehydrogenase:Katalytische Konzentration:Zeitpunkt:Liquor:Quantitativ:Reaktion: Pyruvat zu Lactat
Synonyms: LDH; Zerebrospinalflüssigkeit
es-ES Spanish (Spain) Lactato deshidrogenasa:Concentración Catalítica:Punto temporal:Líquido Cefalorraquideo:Qn:Reacción - piruvato lactato
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Lactato deshidrogenasa:Concentración catalítica:Punto temporal:Fluído espinal cerebral:Cuantitativo:Reacción - piruvato a lactato
fr-CA French (Canada) Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:LCR:Quantitatif:Réaction: pyruvate en lactate
fr-FR French (France) Lactate déhydrogénase:Catalytique/Volume:Ponctuel:Liquide céphalorachidien:Numérique:Réaction : Pyruvate vers Lactate
fr-BE French (Belgium) Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:LCR:Quantitatif:Réaction: pyruvate en lactate
Synonyms: LDH
it-IT Italian (Italy) Lattato deidrogenasi:CCnC:Pt:LCS:Qn:Reazione: piruvato in lattato
Synonyms: Chimica Concentrazione Catalitica Liquido cerebrospinale Punto nel tempo (episodio) Reazione -piruvato in lattato
nl-NL Dutch (Netherlands) lactaatdehydrogenase:enzymatische activiteit/volume:moment:liquor cerebrospinalis:kwantitatief:reactie: pyruvaat naar lactaat
pl-PL Polish (Poland) Dehydrogenaza mleczanowa:stężenie katalityczne:punkt w czasie:płyn mózgowo-rdzeniowy:ilościowy:reakcja P-L, pirogronian-mleczan
pt-BR Portuguese (Brazil) Lactato dehidrogenase::Pt:LCR:Qn:Reação: Piruvato e Lactato
tr-TR Turkish (Turkey) Laktat dehidrojenaz:KtlKons:Zmlı:BOS:Kant:Reaksiyon: piruvat tan laktat a
zh-CN Chinese (China) 乳酸脱氢酶:催化浓度:时间点:脑脊液:定量型:反应: 丙酮酸至乳酸
Synonyms: 2-羟基-丙酸;Lact;L-乳酸 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 L.D.H;LD;LDH;L-乳酸脱氢酶 React Rxn 丙酮酸 - 乳酸转化法;丙酮酸 -> 乳酸转化法;丙酮酸转化为乳酸的反应;反应: 丙酮酸 - 乳酸;反应: 丙酮酸 -> 乳酸 催化浓度(单位体积);单位体积内酶的单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 去氢酶 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液

Example Units

Unit Source
U/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=60023-9