Version 2.78

Part Description

LP39188-5   Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome. PMID: 17706564 Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. [http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html] Source: Regenstrief LOINC

Fully-Specified Name

Component
Aquaporin 4 water channel Ab.IgG
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
Immune stain

Additional Names

Short Name
AQP4 H2O channel IgG SerPl Ql ImStn
Display Name
Aquaporin 4 water channel IgG Immune stain Ql
Consumer Name Alpha Get Info
Aquaporin 4 water channel IgG antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.34
Last Updated
Version 2.67
Change Reason
Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG17408-2 Aquaporin 4 water channel Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Receptor de Acuaporina 4 IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Acuaporina 4 canal de agua Ab.IgG:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Mancha inmune
et-EE Estonian (Estonia) Akvaporiin 4 retseptor antikehad.IgG:PrThr:Pt:S/P:Ord:Immuunvärv
Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Plasma Seerum Seerum või plasma
fr-CA French (Canada) Récepteur Aquaporin 4, IgG:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:Coloration immunologique
fr-FR French (France) Aquaporine 4 récepteur anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Coloration immune
fr-BE French (Belgium) Récepteur Aquaporin 4 Anticorps. IgG:PrThr:Temps ponctuel:Sérum/Plasma:Ordinal:Coloration immunologique
Synonyms: Anticorps Coloration. Méthode mmunologique
it-IT Italian (Italy) Acquaporina 4, canale idrico Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:Colorazione immunologica
Synonyms: anticorpi IgG anticorpo Canale idrico dell''acquaporina 4 Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) aquaporine 4 waterkanaal As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:immunokleuring
Synonyms: antistof; antilichaam
pt-BR Portuguese (Brazil) Receptor de Aquaporina 4 Ac.IgG::Pt:Soro/Plas:Ord:Imunocoloração
ru-RU Russian (Russian Federation) Аквапорина 4 рецепторы Ат.IgG:PrThr:ТчкВрм:Сыв/Плаз:Пор:Иммуногистохимическая окраска
Synonyms: Антитело Плазма Порядковый Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Akuaporin 4 reseptörü Ab.IgG:MevcEşik:Zmlı:Ser/Plaz:Srl:İmmün boyama
Synonyms: Ak Ak.IgG Mevcut
zh-CN Chinese (China) 水通道蛋白 4 受体 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:免疫染色法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 Devic 氏综合征 IgG Devic 综合征 IgG Devic氏综合征 Ab.IgG Devic氏综合征抗体.IgG Devic综合征 Ab.IgG Devic综合征抗体.IgG H2O NMO Ab.IgG NMO 抗体.IgG 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 染法 染色方法 染色法 着色 着色方法 着色法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆 视神经脊髓炎 Ab.IgG 视神经脊髓炎 IgG

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=61117-8