61117-8

Aquaporin 4 water channel IgG Ab [Presence] in Serum or Plasma by Immune stain

Active

Part Description

LP39188-5 Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome. PMID: 17706564 Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Aquaporin 4 water channel Ab.IgG:PrThr:Pt:Ser/Plas:Ord:Immune stain
Long Common Name: Aquaporin 4 water channel IgG Ab [Presence] in Serum or Plasma by Immune stain
Short Name: AQP4 H2O channel IgG SerPl Ql ImStn
Display Name: Aquaporin 4 water channel IgG Immune stain Ql
Consumer Name Alpha Get Info: Aquaporin 4 water channel IgG antibody, Blood

Part Model Get Info

Component
Aquaporin 4 water channel Ab.IgG
LP39188-5
- Analyte
  Aquaporin 4 water channel Ab.IgG
  LP39188-5
  - Component Numerator
    Aquaporin 4 water channel Ab.IgG
    LP39188-5
    - Component Numerator Core
      Aquaporin 4 water channel
      LP102619-6
    - Component Numerator Core Suffix
      Ab.IgG
      LP32401-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Immune stain
LP6333-1

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.34
Last Updated: Version 2.67 (NAM)
Change Reason: Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG17408-2	Aquaporin 4 water channel Ab.IgG\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Akvaporin 4 IgG:Přítomnost nebo práh:Časový bod:Sérum/plazma:Ordinální:Imunobarvení
el-GR	Greek (Greece)	Δίαυλος ύδατος ακουαπορίνης 4 Αντισώματα IgG:PrThr:Pt:Ορός/Πλάσμα:Ord:Ανοσολογική χρώση Synonyms: Ord PrThr Pt SERO Ανοσολογική χρώση Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Δίαυλος ύδατος ακουαπορίνης 4 Νερό Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	Receptor de Acuaporina 4 IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Tinción de inmunohistoquímica
es-MX	Spanish (Mexico)	Acuaporina 4 canal de agua Ab.IgG:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Mancha inmune
et-EE	Estonian (Estonia)	Akvaporiin 4 retseptor antikehad.IgG:PrThr:Pt:S/P:Ord:Immuunvärv Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Plasma Seerum Seerum või plasma
fr-CA	French (Canada)	Canal de l'eau Aquaporin 4, IgG:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:Coloration immunologique
fr-FR	French (France)	Aquaporine 4 récepteur Ac IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Coloration immune
fr-BE	French (Belgium)	Récepteur Aquaporin 4 Anticorps. IgG:PrThr:Temps ponctuel:Sérum/Plasma:Ordinal:Coloration immunologique Synonyms: Anticorps Coloration. Méthode mmunologique
it-IT	Italian (Italy)	Acquaporina 4, canale idrico Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:Colorazione immunologica Synonyms: anticorpi IgG anticorpo Canale idrico dell''acquaporina 4 Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	aquaporine 4 waterkanaal As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:immunokleuring Synonyms: antistof; antilichaam
ru-RU	Russian (Russian Federation)	Аквапорина 4 рецепторы Ат.IgG:PrThr:ТчкВрм:Сыв/Плаз:Пор:Иммуногистохимическая окраска Synonyms: Антитело Плазма Порядковый Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	Akuaporin 4 reseptörü Ab.IgG:MevcEşik:Zmlı:Ser/Plaz:Srl:İmmün boyama Synonyms: Ak Ak.IgG Mevcut
zh-CN	Chinese (China)	水通道蛋白 4 受体抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:免疫染色法 Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 Devic 氏综合征 IgG Devic 综合征 IgG Devic氏综合征 Ab.IgG Devic氏综合征抗体.IgG Devic综合征 Ab.IgG Devic综合征抗体.IgG H2O NMO Ab.IgG NMO 抗体.IgG 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间染法染色方法染色法着色着色方法着色法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类血清或血浆视神经脊髓炎 Ab.IgG 视神经脊髓炎 IgG

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=61117-8

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.