61152-5

Albumin [Mass/volume] in Serum or Plasma by Bromocresol purple (BCP) dye binding method

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Term Description

Albumin is a predictor of morbidity and mortality in dialysis patients. Bromocresol green (BCG) and bromocresol purple (BCP) dye binding methods differ enough in results for serum albumin in hemodialysis patients to necessitate distinct LOINC codes.
(1) Nephrol Dial Transplant (2000) 15: 1819-1822 Albumin as an outcome measure in haemodialysis in patients: the effect of variation in assay method. Carfray, Alison et al.
BCG reacts with alpha-1 and alpha-2 globulins, as well as albumin, whereas BCP appears to react more specifically with albumin. The consequence is that BCG results will be higher than BCP results. See attached paper which shows a consistent difference of approximately 5.5 g/L in all classes of patients - not just nephrology/dialysis patients. Clase et al, Neph Dial Transplant, 2001;16:1925-9. This is the only paper we found that that compared BCG and BCP in any significant number of non-renal patients. There are other arguments about these two methods in renal dialysis patients. Both hemodialysis and peritoneal dialysis patients commonly have an inhibitor (CMPF) that competes with the dye for albumin binding sites. Doumas and Peters, Clin Chem 2009;55:583-584 (this is a reprint of a "citation classic", originally published in Clin Chim Acta 1971;31:87), point out the differences between BCG and BCP albumin results, and state that is essential for laboratories to establish separate reference ranges for each, and to advise their clinical customers of the differences.
Source: Regenstrief Help

Part Description

LP6118-6 Albumin
A non-glycosylated protein that is synthesized in the liver parenchymal cells, regulated by colloid osmotic pressure from interstitial fluid surrounding hepatocytes, and catabolized in nearly all organs. Albumin comprises >50% of plasma proteins in plasma, CSF and urine, and therefore is a key contributor to intravascular oncotic pressure and regulating fluid concentration in tissues. Albumin also binds and transports a variety of endogenous substances and medications. Serum albumin measurement is a reflection of hydration and nutritional status, blood oncotic pressure, liver and kidney function, and other chronic diseases, and the ratio of albumin in the CSF and serum can be used to evaluate blood brain barrier disorders. [Tietz] Urine albumin of less than 30 mg/day is considered normal. Microalbuminuria is defined as urine albumin of 30-300 mg/day and is an early sign of kidney damage from disorders such as diabetes or hypertension. Albuminuria is urine albumin >300 mg/day and is associated with overt kidney disease. PMID: 25512779 Source: Regenstrief LOINC

Fully-Specified Name

Component: Albumin
Property: MCnc
Time: Pt
System: Ser/Plas
Scale: Qn
Method: BCP

Additional Names

Short Name: Albumin SerPl BCP-mCnc
Display Name: Albumin BCP dye [Mass/Vol]
Consumer Name Alpha Get Info: Albumin, Blood

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.34
Last Updated: Version 2.73
Order vs. Observation: Both
Common Test Rank Get Info: 215

Member of these Groups Get Info

LOINC Group	Group Name
LG5465-2	Albumin\|MCnc\|Pt\|ANYBldSerPl
LG33735-8	Albumin\|Pt\|Ser/Plas\|BCP\|2754.105 g/mole

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Albumin:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:Bromkresolpurpur-Färbung (BCP)
es-ES	Spanish (Spain)	Albúmina:Concentración de masa:Punto temporal:Suero o Plasma:Qn:BCP Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Albúmina:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Método de unión del tinte púrpura de bromocresol (BCP)
fr-CA	French (Canada)	Albumine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:Pourpre de bromocrésol
fr-FR	French (France)	Albumine:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Coloration violet de bromocrésol
fr-BE	French (Belgium)	Albumine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:Pourpre de bromocrésol
it-IT	Italian (Italy)	Albumina:MCnc:Pt:Siero/Plasma:Qn:BCP Synonyms: Chimica Concentrazione di Massa Metodo dye binding al violetto di bromocresolo (BC Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL	Dutch (Netherlands)	albumine:massa/volume:moment:serum of plasma:kwantitatief:BCP Synonyms: broomcresolpaars
pl-PL	Polish (Poland)	Albumina:stężenie masowe:punkt w czasie:surowica lub osocze:ilościowy:metoda wiązania czerwieni bromokrezolowej (BCP)
pt-BR	Portuguese (Brazil)	Albumina::Pt:Soro/Plas:Qn:BCP
tr-TR	Turkish (Turkey)	Albumin:KütlKons:Zmlı:Ser/Plaz:Kant:BCP Synonyms: Bromkrezol moru boya bağlama yöntemi
zh-CN	Chinese (China)	白蛋白:质量浓度:时间点:血清/血浆:定量型:溴甲酚紫染料结合法 Synonyms: Alb;清蛋白;白;白朊;蛋白素;蛋白胚乳;蛋白质.白蛋白;血液制品 - 白蛋白 BCP 结合法;溴甲酚紫;Bromocresol purple;BCP 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间水平;浓度;质量浓度(单位体积) 血清或血浆

Example Units

Unit	Source
g/dL	Example UCUM Units

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.