Version 2.77

Part Descriptions

LP36464-3   Microsatellite instability
The appearance of abnormally long or short microsatellites in an individual's DNA is referred to as microsatellite instability. Microsatellite instability (MSI) is a condition manifested by damaged DNA due to defects in the normal DNA repair process. Sections of DNA called microsatellites, which consist of a sequence of repeating units of 1-6 base pairs in length, become unstable and can shorten or lengthen. Microsatellites are also known as simple sequence repeats (SSRs). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP36464-3   Microsatellite instability
Microsatellite instability (MSI) is a change in the number of repeats of a specific DNA marker in cancer cells compared to the number of repeats present in non-cancerous cells of the same patient. Different tumor types are associated with different MSI markers, and both the presence of MSI in specific markers as well as the the number of distinct markers demonstrating MSI is important. Tumor cells are classified as being stable, having high instability (MSI-H), or having low instability (MSI-L) based on the number of markers demonstrating MSI. MSI analysis may help guide therapy and be a prognostic indicator. Specific MSI markers include BAT25, BAT26, D2S123, D5S346, D17S2720, NR21, NR24 and MONO27. MSI has been most studied in colorectal cancer, and colorectal tumors that are MSI-H are more likely to be carcinomas than adenomas. MSI has also been studied in other types of cancer, including gastric cancer, breast cancer, lung cancer and Wilms tumor. Source: Regenstrief LOINC

Fully-Specified Name

Component
Microsatellite instability
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
MSI Tiss Ql ImStn
Display Name
Microsatellite instability Immune stain Ql (Tiss)
Consumer Name Alpha Get Info
Microsatellite instability, Tissue

Example Answer List: LL1057-0

Source: Regenstrief LOINC
Answer Code Score Answer ID
Stable LA14122-8
Unstable LA14123-6
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.36
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
11719

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Inestabilidad microsatelite:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Inestabilidad de microsatélites:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
fr-FR French (France) Microsatellite instabilité:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
it-IT Italian (Italy) Microsatelliti, instabilità:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
Synonyms: Instabilità dei microsatelliti Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
nl-NL Dutch (Netherlands) microsatellietinstabiliteit:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
ru-RU Russian (Russian Federation) Микросателлитная нестабильность:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
Synonyms: Порядковый Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) Mikrosatellit kararsızlık:MevcEşik:Zmlı:Doku:Srl:İmmün boyama
Synonyms: Mevcut
zh-CN Chinese (China) 微卫星不稳定性:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
Synonyms: MSI 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=62862-8