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Term Description

This protocol includes instructions for drawing, processing and storing blood according to the Type 1 Diabetes Genetics Consortium (T1DGC) Manual of Operations. Human Leukocyte Antigen is measured by using the linear array genotyping system method. The PhenX Infectious Diseases and Immunity Working Group would like to note that the science of HLA matching is rapidly advancing and evolving and multiple methods for HLA assays are available. To aid in comparability, the Infectious Diseases and Immunity Working Group recommends that the investigator record the make and manufacturer of equipment used and the repeatability and coefficients of variation for the assay. Please also note that the immobilized linear arrays used to genotype the samples were provided by Roche Molecular Systems and are not commercially available.

Part Description

LP20670-3   Leukocyte
Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. There are five types of WBCs normally present in the circulation that are all derived from a similar stem cell in the bone marrow. The five type of WBCs are divided into two groups based on the presence or absence of granules in the cytoplasm. The granulocytes include the neutrophils, basophils and eosinophils. The non-granulocytes include the lymphocytes and the monocytes. The neutrophils fight infection by ingesting and digesting bacteria. Eosinophils and basophils respond to allergic reactions and are capable of ingesting antigen-antibody complexes. Monocytes phagocytose bacteria and release interferon to stimulate the immune system. Lymphocytes are divided into T-cells and B-cells. T-cell immunity is cellular and involves the activation of phagocytes and B-cell immunity uses antibodies to fight infection. Both elevated and low leukocyte counts can be markers of infection and malignancy, and low leukocyte counts are associated with a variety of primary and secondary immunodeficiencies, depending on the WBC type(s) that are out of range. (Mosby's manual of diagnostic and laboratory tests, Kathleen Deska Pagana; Timothy James Pagana, Elsevier St. Louis, Mo ©2010) Source: Regenstrief LOINC

Reference Information

TypeSourceReference
CitationConsensus measures for Phenotypes and ExposuresNIH. NIDDK. Type 1 Diabetes Genetics Consortium Manual Of Operations. Blood Collection and Processing.
CitationConsensus measures for Phenotypes and ExposuresSilke Rosinger, Sarah Nutland, Eric Mickelson, Michael D Varney, Bernard O Boehm, Gary J Olsem, John A Hansen, Ian Nicholson, Joan E Hilner, Letitia H Perdue, June J Pierce, Beena Akolkar, Concepcion Nierras, Michael W Steffes and T1DGC. Collection and processing of whole blood for transformation of peripheral blood mononuclear cells and extraction of DNA: the Type 1 Diabetes Genetics Consortium. Clinical Trials. 2010; 7: S65-S74.
CitationConsensus measures for Phenotypes and ExposuresJosyf C Mychaleckyj, Janelle A Noble, Priscilla V Moonsamy, Joyce A Carlson, Michael D Varner, Jeff Post, Wolfgang Helmberg, June J Pierce, Persia Bonella, Anna Lisa Fear, Eva Lavant, Anthony Louey, Sean Boyle, Julie A Lane, Paul Sali, Samuel Kim, Rebecca Rappner, Dustin T Williams, Letitia H Perdue, David M Reboussin, Brian D Tait, Beena Akolkar, Joan E Hilner, Michael W Steffes, Henry A Erlich and T1DGC. HLA genotyping in the international Type 1 Diabetes Genetics Consortium. Clinical Trials. 2010; 7: S75-S87.

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINCNameR/O/CCardinalityExample UCUM Units
62875-0PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601
Indent51953-8Collection date of Blood
Indent69866-2Process variables for assays - human leukocyte antigen - HLA PhenX
IndentIndent66180-1Was blood drawn?
IndentIndent66181-9Was full sample obtained?
IndentIndent8251-1Service comment
IndentIndent8251-1Service comment
IndentIndent66200-7Repeatability of the assay{ratio}
IndentIndent66201-5Coefficient of variation for the assay{CV}
Indent69864-7Manufacturer variables for assays PhenX
IndentIndent66208-0Make of the equipment used to perform...
IndentIndent74719-6Manufacturer of the equipment used

LOINC Names Get Info

Fully-Specified Name
PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601:-:Pt:^Patient:-:PhenX
Long Common Name
PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601
Short Name
Assay human leukocyte antg (HLA) proto

Part Model Get Info

  • Component
    PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601
    LP112432-2
    • Analyte
      PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601
      LP112432-2
      • Component Numerator
        PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601
        LP112432-2
        • Component Numerator Core
          PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601
          LP112432-2
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    -
    LP6769-6
  • Time
    Pt
    LP6960-1
  • System
    ^Patient
    LP310005-6
    • System Core
      NULL
       
    • Super System
      Patient
      LP6985-8
  • Scale
    -
    LP7747-1
  • Method
    PhenX
    LP95333-8

Survey Question

PX160601

Basic Attributes

Class
PANEL.PHENX
Type
Clinical
First Released
Version 2.36
Last Updated
Version 2.81 (MIN)
Change Reason
Release 2.81: Status: Changing PhenX Concept from Status = Trial to Active; Previous Releases: Updated the PhenX ID from "PhenX.<ID>" to "PX<ID>" in Survey Question Source field to align with the variable identifier used in the PhenX Toolkit.; Added the PhenX protocol ID to the Component to clearly define the protocol version for which this panel is based upon.
Panel Type
Panel

Member of these Panels

LOINCLong Common Name
62863-6PhenX domain - Infectious diseases and immunity

Language Variants Get Info

TagLanguageTranslation
el-GRGreek (Greece)PhenX - προσδιορισμός για γονοτύπηση για ανθρώπινα λευκοκυτταρικά αντιγόνα (HLA) πρωτόκολλο 160601:-:Pt:^Ασθενής:-:PhenX
Synonyms: - PANEL.PHENX PHENX PhenX - προσδιορισμός για γονοτύπηση για ανθρώπινα λευκοκυτταρικά αντιγόνα (HLA) πρωτόκολλο 160601 Pt Ανθρώπινα λευκοκυτταρικά αντιγόνα Ασθενής
es-MXSpanish (Mexico)PhenX: ensayo para el protocolo de genotipado del antígeno leucocitario humano (HLA) 160601:-:Punto temporal:^ Paciente:-:PhenX
it-ITItalian (Italy)PhenX - esame per antigene leucocitario umano ( HLA ) genotipizzazione, protocollo:-:Pt:^Paziente:-:PhenX
Synonyms: Panel PhenX paziente PhenX Punto nel tempo (episodio)
ru-RURussian (Russian Federation)PhenX - анализ на человеческий лейкоцитарный антиген (HLA) генотипирование протокол:-:ТчкВрм:^Пациент:-:PhenX
Synonyms: Точка во времени;Момент
zh-CNChinese (China)PhenX - 人类白细胞抗原基因分型方案 160601:-:时间点:^患者:-:PhenX
Synonyms: Ag Consensus measures for Phenotypes and eXposures;PhenX;暴露;接触;表型与暴露共识指标;表现型与暴露共识指标;表型与暴露公认指标 Consensus measures for Phenotypes and eXposures;表型与暴露共识指标;表现型与暴露共识指标;表型与暴露公认指标 HLA 抗原;人类白细胞抗原;human leukocyte antigen human leukocyte antigen;HLA;人类白细胞抗原;人白细胞抗原;PhenX - 人类白细胞抗原基因分型（基因型分型、基因型分析、基因型定型、基因定型、病毒基因型敏感性试验）方案 160601 Leuc Leuk Lkcs WBC WBCs 人白细胞抗原 人类白细胞抗原 人类白细胞抗原（Human Leukocyte Antigen，HLA） 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.PhenX;组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）.PhenX;Consensus measures for Phenotypes and eXposures;PhenX;表型与暴露共识指标;表现型与暴露共识指标;表型与暴露公认指标;PhenX 医嘱组 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 医疗服务对象;客户;病人;病患;病号;超系统 - 病人 多重;多重型;多重标尺类型;多重精度类型 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 抗体原 时刻;随机;随意;瞬间 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 白 白细胞（White blood cell，WBC） 白细胞抗原 白细胞类 白细胞类（White blood cells，白细胞，WBCs） 白血球 白血球类 白血细胞 白血细胞类 组 组合 组合医嘱 组合类 组套

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=62875-0
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/62875-0