62875-0
PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601
Trial
Status Information
- Status
- TRIAL
Term Description
This protocol includes instructions for drawing, processing and storing blood according to the Type 1 Diabetes Genetics Consortium (T1DGC) Manual of Operations. Human Leukocyte Antigen is measured by using the linear array genotyping system method. The PhenX Infectious Diseases and Immunity Working Group would like to note that the science of HLA matching is rapidly advancing and evolving and multiple methods for HLA assays are available. To aid in comparability, the Infectious Diseases and Immunity Working Group recommends that the investigator record the make and manufacturer of equipment used and the repeatability and coefficients of variation for the assay. Please also note that the immobilized linear arrays used to genotype the samples were provided by Roche Molecular Systems and are not commercially available.
Source: Regenstrief LOINC
Part Description
LP20670-3 Leukocyte
Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. There are five types of WBCs normally present in the circulation that are all derived from a similar stem cell in the bone marrow. The five type of WBCs are divided into two groups based on the presence or absence of granules in the cytoplasm. The granulocytes include the neutrophils, basophils and eosinophils. The non-granulocytes include the lymphocytes and the monocytes. The neutrophils fight infection by ingesting and digesting bacteria. Eosinophils and basophils respond to allergic reactions and are capable of ingesting antigen-antibody complexes. Monocytes phagocytose bacteria and release interferon to stimulate the immune system. Lymphocytes are divided into T-cells and B-cells. T-cell immunity is cellular and involves the activation of phagocytes and B-cell immunity uses antibodies to fight infection. Both elevated and low leukocyte counts can be markers of infection and malignancy, and low leukocyte counts are associated with a variety of primary and secondary immunodeficiencies, depending on the WBC type(s) that are out of range. (Mosby's manual of diagnostic and laboratory tests, Kathleen Deska Pagana; Timothy James Pagana, Elsevier St. Louis, Mo ©2010)
Source: Regenstrief LOINC
Reference Information
Type | Source | Reference |
---|---|---|
Citation | Consensus measures for Phenotypes and Exposures | NIH. NIDDK. Type 1 Diabetes Genetics Consortium Manual Of Operations. Blood Collection and Processing. |
Citation | Consensus measures for Phenotypes and Exposures | Silke Rosinger, Sarah Nutland, Eric Mickelson, Michael D Varney, Bernard O Boehm, Gary J Olsem, John A Hansen, Ian Nicholson, Joan E Hilner, Letitia H Perdue, June J Pierce, Beena Akolkar, Concepcion Nierras, Michael W Steffes and T1DGC. Collection and processing of whole blood for transformation of peripheral blood mononuclear cells and extraction of DNA: the Type 1 Diabetes Genetics Consortium. Clinical Trials. 2010; 7: S65-S74. |
Citation | Consensus measures for Phenotypes and Exposures | Josyf C Mychaleckyj, Janelle A Noble, Priscilla V Moonsamy, Joyce A Carlson, Michael D Varner, Jeff Post, Wolfgang Helmberg, June J Pierce, Persia Bonella, Anna Lisa Fear, Eva Lavant, Anthony Louey, Sean Boyle, Julie A Lane, Paul Sali, Samuel Kim, Rebecca Rappner, Dustin T Williams, Letitia H Perdue, David M Reboussin, Brian D Tait, Beena Akolkar, Joan E Hilner, Michael W Steffes, Henry A Erlich and T1DGC. HLA genotyping in the international Type 1 Diabetes Genetics Consortium. Clinical Trials. 2010; 7: S75-S87. |
Panel Hierarchy
Details for each LOINC in Panel LHC-Forms
LOINC | Name | R/O/C | Cardinality | Example UCUM Units |
---|---|---|---|---|
62875-0 | PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601 | |||
Indent51953-8 | Collection date of Blood | |||
Indent69866-2 | Process variables for assays - human leukocyte antigen - HLA PhenX | |||
Indent Indent66180-1 | Was blood drawn? | |||
Indent Indent66181-9 | Was full sample obtained? | |||
Indent Indent8251-1 | Service comment | |||
Indent Indent8251-1 | Service comment | |||
Indent Indent66200-7 | Repeatability of the assay | {ratio} | ||
Indent Indent66201-5 | Coefficient of variation for the assay | {CV} | ||
Indent69864-7 | Manufacturer variables for assays PhenX | |||
Indent Indent66208-0 | Make of the equipment used to perform... | |||
Indent Indent74719-6 | Manufacturer of the equipment used |
Fully-Specified Name
- Component
- PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601
- Property
- -
- Time
- Pt
- System
- ^Patient
- Scale
- -
- Method
- PhenX
Additional Names
- Short Name
- Assay human leukocyte antg (HLA) proto
Survey Question
- Source
- PX160601
Basic Attributes
- Class
- PANEL.PHENX
- Type
- Clinical
- First Released
- Version 2.36
- Last Updated
- Version 2.67
- Change Reason
- Updated the PhenX ID from "PhenX.<ID>" to "PX<ID>" in Survey Question Source field to align with the variable identifier used in the PhenX Toolkit.; Added the PhenX protocol ID to the Component to clearly define the protocol version for which this panel is based upon.
- Panel Type
- Panel
Member of these Panels
LOINC | Long Common Name |
---|---|
62863-6 | PhenX domain - Infectious diseases and immunity |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-MX | Spanish (Mexico) | PhenX: |
it-IT | Italian (Italy) | PhenX - esame per antigene leucocitario umano ( HLA ) genotipizzazione, protocollo: Synonyms: Panel PhenX paziente PhenX Punto nel tempo (episodio) |
ru-RU | Russian (Russian Federation) | PhenX - анализ на человеческий лейкоцитарный антиген (HLA) генотипирование протокол: Synonyms: Точка во времени; |
zh-CN | Chinese (China) | PhenX - 人类白细胞抗原基因分型方案 160601: Synonyms: Ag Consensus measures for Phenotypes and eXposures; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=62875-0 - Questionnaire definition
- https:
//fhir.loinc.org/Questionnaire/?url=http: //loinc.org/q/62875-0
LOINC Copyright
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