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Term Description

This protocol uses two-step serologic testing of serum to determine the presence of antihuman recombinant tissue transglutaminase (TTG) and endomysial antibody (EMA). When both tests are positive, the subject is notified that they are positive for celiac sprue. The test is most accurate if patients have not been on a gluten-free diet in the weeks leading up to the assay, as a gluten-free diet may cause the serologic assays to normalize in many patients. It is important that the patients screened with this laboratory assay are eating a diet that contains dietary sources of gluten in order for the assay to be most accurate. Sources of dietary gluten include the grains wheat, rye, and barley. The Gastrointestinal Working Group (WG) also recommends performing the immunoglobulin A (IgA) and immunoglobulin G (IgG) antibody tests for more sensitivity. The National Health and Nutrition Examination Survey (NHANES) uses red-top tubes to collect 0.5 ml serum for the antihuman recombinant tissue transglutaminase (TTG)/ endomysial antibody (EMA) bioassay. However, the Gastrointestinal Working Group recommends consulting the laboratory that will perform the bioassay regarding the appropriate collection tubes to use.

Reference Information

TypeSourceReference
CitationConsensus measures for Phenotypes and ExposuresCenters for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Questionnaire. Laboratory Procedures Manual. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2009-2010.
ArticleConsensus measures for Phenotypes and ExposuresDieterich, W., Ehnis, T., Bauer, M., Donner, P., Volta, U., Riecken, E. O., & Schuppan, D. (1997). Identification of tissue transglutaminase as the autoantigen of celiac disease. National Medicine, 3(7), 797-801.
ArticleConsensus measures for Phenotypes and ExposuresDieterich, W., Laag, E., Schopper, H., Volta, U., Ferguson, A., Gillett, H., Riecken, E. O., & Schuppan, D. (1998). Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology, 115(6), 1317-1321.
ArticleConsensus measures for Phenotypes and ExposuresGreen, P. H., Rostami, K., & Marsh, M. N. (2005). Diagnosis of coeliac disease. Best Practice and Research Clinical Gastroenterology, 19(3), 389-400.

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINCNameR/O/CCardinalityExample UCUM Units
62957-6PhenX - celiac sprue assay protocol 190301
Indent66177-7Do you have hemophilia?
Indent66178-5Have you received cancer chemotherapy in the past four weeks or do you anticipate such therapy in the next four weeks?
Indent66504-2Exclusion Criteria
Indent66180-1Was blood drawn?
Indent66181-9Was full sample obtained?
Indent8251-1Service comment
Indent8251-1Service comment
Indent66208-0Make of the equipment used to perform...
Indent74719-6Manufacturer of the equipment used
Indent66200-7Repeatability of the assay{ratio}
Indent66201-5Coefficient of variation for the assay{CV}
Indent66208-0Make of the equipment used to perform...
Indent74719-6Manufacturer of the equipment used
Indent66200-7Repeatability of the assay{ratio}
Indent66201-5Coefficient of variation for the assay{CV}

LOINC Names Get Info

Fully-Specified Name
PhenX - celiac sprue assay protocol 190301:-:Pt:^Patient:-:PhenX
Long Common Name
PhenX - celiac sprue assay protocol 190301
Short Name
Celiac sprue assay proto

Part Model Get Info

  • Component
    PhenX - celiac sprue assay protocol 190301
    LP112511-3
    • Analyte
      PhenX - celiac sprue assay protocol 190301
      LP112511-3
      • Component Numerator
        PhenX - celiac sprue assay protocol 190301
        LP112511-3
        • Component Numerator Core
          PhenX - celiac sprue assay protocol 190301
          LP112511-3
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    -
    LP6769-6
  • Time
    Pt
    LP6960-1
  • System
    ^Patient
    LP310005-6
    • System Core
      NULL
       
    • Super System
      Patient
      LP6985-8
  • Scale
    -
    LP7747-1
  • Method
    PhenX
    LP95333-8

Survey Question

PX190301

Basic Attributes

Class
PANEL.PHENX
Type
Clinical
First Released
Version 2.36
Last Updated
Version 2.81 (MIN)
Change Reason
Release 2.81: Status: Changing PhenX Concept from Status = Trial to Active; Previous Releases: Updated the PhenX ID from "PhenX.<ID>" to "PX<ID>" in Survey Question Source field to align with the variable identifier used in the PhenX Toolkit.; Added the PhenX protocol ID to the Component to clearly define the protocol version for which this panel is based upon.
Panel Type
Panel

Member of these Panels

LOINCLong Common Name
62949-3PhenX domain - Gastrointestinal

Language Variants Get Info

TagLanguageTranslation
el-GRGreek (Greece)PhenX - δοκιμασία κοιλιοκάκης πρωτόκολλο 190301:-:Pt:^Ασθενής:-:PhenX
Synonyms: - PANEL.PHENX PHENX PhenX - δοκιμασία κοιλιοκάκης πρωτόκολλο 190301 Pt Ασθενής
es-MXSpanish (Mexico)PhenX - protocolo de ensayo de esprúe celíaco 190301:-:Punto temporal:^ Paciente:-:PhenX
it-ITItalian (Italy)PhenX - esame sprue celiaca, protocollo:-:Pt:^Paziente:-:PhenX
Synonyms: Panel PhenX paziente PhenX Punto nel tempo (episodio)
ru-RURussian (Russian Federation)PhenX - целиакия анализ протокол:-:ТчкВрм:^Пациент:-:PhenX
Synonyms: Точка во времени;Момент
zh-CNChinese (China)PhenX - 脂肪便症检测方案 190301:-:时间点:^患者:-:PhenX
Synonyms: Consensus measures for Phenotypes and eXposures;PhenX;暴露;接触;表型与暴露共识指标;表现型与暴露共识指标;表型与暴露公认指标 Consensus measures for Phenotypes and eXposures;表型与暴露共识指标;表现型与暴露共识指标;表型与暴露公认指标 PhenX - 脂肪泻检测方案 190301;Consensus measures for Phenotypes and eXposures;PhenX;暴露;接触;表型与暴露共识指标;表现型与暴露共识指标;表型与暴露公认指标 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.PhenX;组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）.PhenX;Consensus measures for Phenotypes and eXposures;PhenX;表型与暴露共识指标;表现型与暴露共识指标;表型与暴露公认指标;PhenX 医嘱组 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 医疗服务对象;客户;病人;病患;病号;超系统 - 病人 多重;多重型;多重标尺类型;多重精度类型 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 时刻;随机;随意;瞬间 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 组 组合 组合医嘱 组合类 组套

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=62957-6
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/62957-6