63316-4

U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

Active

Part Description

LP69897-4 U1 small nuclear ribonucleoprotein 70kD
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915 Source: Regenstrief LOINC, PMID: 24158973

LOINC Names Get Info

Fully-Specified Name: U1 small nuclear ribonucleoprotein 70kD Ab:ACnc:Pt:Ser:Qn:IA
Long Common Name: U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
Short Name: U1 snRNP70 Ab Ser IA-aCnc
Display Name: U1 small nuclear ribonucleoprotein 70kD Ab IA Qn (S)
Consumer Name Alpha Get Info: U1 small nuclear ribonucleoprotein 70kD antibody, Blood

Part Model Get Info

Component
U1 small nuclear ribonucleoprotein 70kD Ab
LP69894-1
- Analyte
  U1 small nuclear ribonucleoprotein 70kD Ab
  LP69894-1
  - Component Numerator
    U1 small nuclear ribonucleoprotein 70kD Ab
    LP69894-1
    - Component Numerator Core
      U1 small nuclear ribonucleoprotein 70kD
      LP69897-4
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.36
Last Updated: Version 2.73 (MIN)
Change Reason: The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 8812

Member of these Groups Get Info

LOINC Group	Group Name
LG24688-0	U1 small nuclear ribonucleoprotein 70kD Ab\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	U1 malý jaderný ribonukleoprotein 70kD Ab:Arbitrární koncentrace:Časový bod:Sérum:Kvantitativní:Imunoanalýza
de-AT	German (Austria)	Synonyms: RNP70-Antikörper EIA
el-GR	Greek (Greece)	Μικρή πυρηνική ριβονουκλεοπρωτεΐνη 70kD Αντίσωμα:ACnc:Pt:Ορός:Qn:IA Synonyms: ACnc IA Pt Qn SERO Αντίσωμα Μικρή πυρηνική ριβονουκλεοπρωτεΐνη 70kD Μικρή πυρηνική ριβονουκλεοπρωτεΐνη U1 Ορός Πυρηνικό
es-ES	Spanish (Spain)	U1 ribonucleoproteína nuclear pqueña de 70kD Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Ribonucleoproteína nuclear sub U1 70kD Ab:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Inmunoensayo
fr-CA	French (Canada)	Petite particule nucléaire ribonucléoprotéique U1 70kD, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:IA
fr-FR	French (France)	RNP 70kD Ac:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Immunoanalyse
fr-BE	French (Belgium)	Petite particule nucléaire ribonucléoprotéique U1 70kD Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:IA Synonyms: Anticorps
it-IT	Italian (Italy)	U1, piccola ribonucleoproteina nucleare 70kD Ab:ACnc:Pt:Siero:Qn:IA Synonyms: anticorpo Concentrazione Arbitraria Immunoassay Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 70kD Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	u1 small nucleair ribonucleoproteïne 70kD As:eenheid/volume:moment:serum:kwantitatief:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	U1 mała jądrowa nukleoproteina 70kDa Ab:stężenie w jednostkach umownych:punkt w czasie:surowica:ilościowy:metoda immunologiczna Synonyms: Mała rybonukleoproteina jądrowa U1 U1-snRNP 70 kDa
ru-RU	Russian (Russian Federation)	U1 малый ядерный рибонуклеопротеин 70кД Ат:ПроизвКонц:ТчкВрм:Сыв:Колич:IA Synonyms: Антитело Количественный Произвольная концентрация Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	U1 kçk nükleer ribonükleoprotein 70kD Ab:SçKons:Zmlı:Ser:Kant:İA Synonyms: Ak Çekirdek İmmünölçüm, immünoassay
zh-CN	Chinese (China)	U1 小细胞核核糖核蛋白 70kD 抗体:任意型浓度:时间点:血清:定量型:免疫测定法 Synonyms: Ab;自身抗体 RNP snRNP U1 RNP 70kD;U1 snRNP 70kD;U1 小细胞核核糖核蛋白 70kD;U1 small nuclear ribonucleoprotein 70kD;U1RNP 70kD U1 RNP;U1 snRNP;U1 小细胞核核糖核蛋白;U1 small nuclear ribonucleoprotein;U1RNP 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺小分子核糖核蛋白体小分子细胞核核糖核蛋白小核核糖核蛋白（Small nuclear ribonucleoprotein，snRNP）时刻;随机;随意;瞬间核;胞核核内小核糖核蛋白核微小核糖核蛋白核糖核蛋白（Ribonucleoprotein，Ribonuclear protein，RNP）核蛋白血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.