Version 2.80

6896-5 cloZAPine [Mass/volume] in Serum or Plasma

Term Description

Per ARUP, clozapine levels are used to evaluate toxicity and monitor therapeutic drug levels. 100 ng/mL is the minimum therapeutic threshold, and levels > 1200 ng/mL increase the likelihood of adverse effects such as seizures.

Part Descriptions

LP17236-8   cloZAPine
Clozapine (sold as Clozaril ®, Leponex ®, Fazaclo ®) was the first of the atypical antipsychotics to be developed. It was approved by the United States Food and Drug Administration (FDA) in 1989 and is the only FDA-approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Clozapine (Wikipedia)

LP17236-8   cloZAPine
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. Source: National Library of Medicine, MeSH 2006

Observation Required in Panel

Required

Fully-Specified Name

Component
cloZAPine
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0h(2)
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
2327

Member of these Panels

LOINC Long Common Name
65632-2 cloZAPine and Norclozapine panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG48379-8 Clozapine|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Clozapin
de-DE German (Germany) Clozapin:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
el-GR Greek (Greece) Κλοζαπίνη:MCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: MCnc Κλοζαπίνη
es-AR Spanish (Argentina) clozapina:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-MX Spanish (Mexico) clozapina:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Clozapina:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Klosapiin:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-FR French (France) Clozapine:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Clozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-CA French (Canada) Clozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
Synonyms: #REF!
it-IT Italian (Italy) Clozapina:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 클로자핀:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) clozapine:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Clozapina:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Clozaril; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Клозапин:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Klozapine:KütlKons:Zmlı:Ser/Plaz:Kant:
uk-UA Ukrainian (Ukraine) клозапін:Масова Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:
Synonyms: Clozaril; DRUG/TOXICOLOGY; Drugs; FazaClo; Leponex; Level; Mass concentration; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; UniversalLabOrders
zh-CN Chinese (China) 氯氮平:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 氯扎平 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ng/mL Example UCUM Units
ug/L eCHN

10992-6 Norclozapine [Mass/volume] in Serum or Plasma

Part Descriptions

LP18081-7   Norclozapine
Norclozapine (desmethyl-clozapine),a major metabolite of clozapine, is pharmacologically active. The cytochrome P450 isoenzyme 1A2 is primarily responsible for clozapine metabolism, but 2C, 2D6, 2E1 and 3A3/4 appear to play roles as well. Agents which induce (e.g. cigarette smoke) or inhibit (e.g. theophylline, ciprofloxacin, fluvoxamine) CYP1A2 may increase or decrease, respectively, the metabolism of clozapine. For example, the induction of metabolism caused by smoking means that smokers require up to double the dose of clozapine compared with non-smokers to achieve an equivalent plasma concentration. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Norclozapine

Condition for Inclusion

: Either a) "Clozapine+Norclozapine" and/or b) "Norclozapine" must be included for a valid panel

Observation Required in Panel

Conditional

Fully-Specified Name

Component
Norclozapine
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0j-a
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
2369

Member of these Panels

LOINC Long Common Name
65632-2 cloZAPine and Norclozapine panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG578-1 Norclozapine|MCnc|Pt|ANYBldSerPl
LG47389-8 Norclozapine|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Norclozapin
de-DE German (Germany) Norclozapin:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
Synonyms: Desmethylclozapin
el-GR Greek (Greece) Νορκλοζαπίνη:MCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: MCnc
es-AR Spanish (Argentina) norclozapina:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-MX Spanish (Mexico) Norclozapina:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Norclozapina:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Norklosapiin:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-BE French (Belgium) Norclozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Norclozapine:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-CA French (Canada) Norclozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Norclozapina:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) Norclozapine:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) norclozapine:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Norclozapina:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Clozapine metAcolite; Desmethylclozapine; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Норклозапин:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Norklozapin:KütlKons:Zmlı:Ser/Plaz:Kant:
uk-UA Ukrainian (Ukraine) Норклозапін:Масова Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:
Synonyms: Clozapine metabolite; Desmethylclozapine; DRUG/TOXICOLOGY; Drugs; Level; Mass concentration; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR
zh-CN Chinese (China) 去甲基氯氮平:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 脱甲基氯氮平;去甲基氯扎平;去甲氯扎平;去甲氯氮平;氯扎平代谢产物;氯氮平代谢产物 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ng/mL Example UCUM Units
ng/mL REGENSTRIEF

12375-2 cloZAPine+Norclozapine [Mass/volume] in Serum or Plasma

Condition for Inclusion

: Either a) "Clozapine+Norclozapine" and/or b) "Norclozapine" must be included for a valid panel

Observation Required in Panel

Conditional

Fully-Specified Name

Component
Clozapine+Norclozapine
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0j-a
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
5248

Member of these Panels

LOINC Long Common Name
65632-2 cloZAPine and Norclozapine panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG43794-3 Clozapine+Norclozapine|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κλοζαπίνη+Νορκλοζαπίνη:MCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: MCnc
es-AR Spanish (Argentina) clozapina+norclozapina:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-MX Spanish (Mexico) cloZAPina + Norclozapina:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Clozapina+Norclozapina:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Klosapiin + norklosapiin:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-BE French (Belgium) Clozapine+Norclozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Clozapine+norclozapine:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-CA French (Canada) Clozapine+Norclozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
Synonyms: #REF!
it-IT Italian (Italy) Clozapina+Norclozapina:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 클로자핀+노르클로자핀:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) clozapine + norclozapine:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Clozapina+Norclozapina:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Clozapine metAcolite; Desmethylclozapine; Clozapine+Nor; Clozaril; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Клозапин+Норклозапин:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Klozapine+NorKlozapine:KütlKons:Zmlı:Ser/Plaz:Kant:
uk-UA Ukrainian (Ukraine) Клозапін+Норклозапін:Масова Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:
Synonyms: Clozapine metabolite; Clozaril; Desmethylclozapine; DRUG/TOXICOLOGY; Drugs; FazaClo; Leponex; Level; Mass concentration; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR
zh-CN Chinese (China) 氯氮平+去甲基氯氮平:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 氯扎平 水平;浓度;质量浓度(单位体积) 脱甲基氯氮平;去甲基氯扎平;去甲氯扎平;去甲氯氮平;氯扎平代谢产物;氯氮平代谢产物 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ug/mL Example UCUM Units
ng/mL REGENSTRIEF