Version 2.80

Term Description

The Silica Clotting Time (SCT) refers to a version of the activated partial thromboplastin time (aPTT) in which:
1) silica replace kaolin as activator in order to make the test amenable to automation (since kaolin is opaque) and
2) there is a screening reagent with very low phospholipid concentration, diminished compared to the standard aPTT reagent, to maximize sensitivity to lupus anticoagulant (LAC) and
3) there is a confirmatory reagent which uses excess phospholipid in an attempt to neutralize the putative LAC.
(Original reference: Chantarangkul et al., Silica Clotting Time (SCT) as a Screening and Confirmatory Test Detection of the Lupus Anticoagulants. 1992. Thrombosis Research 67:355-365.)
The normalize SCT ratio is calculated as follows:
(Patient Screen Result in seconds / Mean Normal Screen Result in seconds) / (Patient Confirm Result in seconds / Mean Normal Confirm Result in seconds).
The prototype test described by this code is the HemosIL(TM) Silica CLotting Time test. LabCorp performs a test similar to the screening step called "Partial Thromboplastin Time (PTT), Lupus Anticoagulant" (LabCorp #117002) which also uses silica and diminished PL, but apparently they do not report it as a normalized ratio.

Part Description

LP129053-7   Normalized silica clotting time
The silica clotting time (SCT) is a PTT-like assay that uses colloidal silica as its negatively charged particulate activator and is useful in the diagnosis of lupus anticoagulant.

The patient's Screen and Confirm results are divided by their respective means to produce normalized SCT Screen and SCT Confirm ratios. The normalized clotting time is calculated by dividing the patient SCT Screen ratio the patient SCT Confirm ratio to generate the normalized SCT ratio. Source: The Fritzma Factor , The Fritzma Factor

Fully-Specified Name

Component
Normalized silica clotting time
Property
Ratio
Time
Pt
System
PPP
Scale
Qn
Method

Additional Names

Long Common Name
Normalized silica clotting time of Platelet poor plasma
Short Name
Normalized SCT PPP-Rto
Display Name
Normalized silica clotting time (PPP) [Ratio]
Consumer Name Alpha Get Info
Normalized silica clotting time, Blood

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 2.38
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
2662

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κανονικοποιημένος χρόνος πήξης πυριτίου:Ratio:Pt:PPP:Qn:
Synonyms: Ratio Time Κανονικοποιημένος χρόνος πήξης πυριτίου Πυρίτιο Χρόνος πήξης Χρόνος πήξης πυριτίου
es-ES Spanish (Spain) Tiempo de coagulación en silicona normalizada:Fracción:Punto temporal:Plasma pobre en plaquetas:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Tiempo de coagulación de la sílice normalizado:Proporción:Punto temporal:Plasma pobre en plaquetas:Cuantitativo:
fr-FR French (France) Temps de coagulation normalisé à la silice:Ratio:Ponctuel:Plasma pauvre en plaquettes:Numérique:
it-IT Italian (Italy) Tempo di coagulazione di silice normalizzato:Rapporto:Pt:PPP:Qn:
Synonyms: Plasma povero di piastrine Punto nel tempo (episodio) SCT Studio di coagulazione
nl-NL Dutch (Netherlands) genormaliseerde silica stollingstijd:verhouding:moment:plaatjesarm plasma:kwantitatief:
Synonyms: coagulatiemethode
ru-RU Russian (Russian Federation) Нормализованное кремниевое свёртывания время:Отношение:ТчкВрм:ОПП:Колич:
Synonyms: Количественный Коэффициент;Соотношение;Пропорция Кремнезём Обеднённая пластинками плазма;Бедная тромбоцитами плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Normalize edilmiş silika pıhtılaşma zamanı:Oran:Zmlı:TFkP:Kant:
zh-CN Chinese (China) 标准化 硅凝血时间:比率:时间点:贫血小板血浆:定量型:
Synonyms: Silica Clotting Time;SCT; 硅凝血时间（凝固时间）;activated partial thromboplastin time;aPTT;活化部分凝血活酶时间;标准化二氧化硅凝血时间（CT）;标准化硅凝血时间（CT） 乏血小板血浆;Platelet poor plasma;PPP 二氧化硅凝血时间（CT）;硅凝血时间（CT） 凝固 凝固时间;血液凝固时间 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 无水硅酸;氧化硅;石英;硅;硅土;硅氧;硅石;硅质;硅酸 时刻;随机;随意;瞬间 时间(如秒);时间(如秒数) 来自于不同体系的两个观察指标之比;比;比值

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