6770-2

Alpha 1 antitrypsin phenotype [Identifier] in Serum or Plasma by Immunofixation

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Part Descriptions

LP17187-3 Alpha 1 antitrypsin phenotype
Alpha-1 antitrypsin deficiency is a relatively common autosomal recessive condition. The most common deficiency alleles in the alpha-1-antitrypsin gene on the protease inhibitor locus are PI*Z and PI*S. The normal allele is PI*M. Patients homozygous for PI*Z or PI*S or heterozygous PI*Z/PI*S will have decreased alpha-1-antitrypsin levels, with PI*Z/PI*Z having lowest levels of 10-20% of normal. Patients with PI*Z/PI*Z or PI*S/PI*Z genotypes reportedly have increased risk of childhood liver disease and chronic obstructive pulmonary disease(COPD) and emphysema in adult life. PI*M/PI*Z patients may have decreased pulmonary function and increased risk for COPD, especially smokers. Source: Regenstrief Institute

LP6336-4 Immunofixation
Plasma or concentrated urine is deposited on a gel. With an electrical current the proteins are sorted in function of their size, after which antigens for each targeted type of immunoglobulin are deposited on the gel. Thus more or less narrow bands appear on the gel, marking the location of the various immunoglobulines.
Immunofixation tends to replace protein electrophoresis because:

• it is faster (results within three hours);
• it is somewhat more sensitive. Immunofixation may reveal an immunoglobulin missed out by protein electrophoresis, especially at low concentrations (less than 1 gram/litre);
• it can be partially automated and can be used in more laboratories;
• it is more easily read and interpreted.

Immunofixation is however only sensitive to immunoglobulins and is more expensive than protein electrophoresis. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Immunofixation

Fully-Specified Name

Component: Alpha 1 antitrypsin phenotype
Property: Prid
Time: Pt
System: Ser/Plas
Scale: Nom
Method: Immunofixation

Additional Names

Long Common Name: Alpha 1 antitrypsin phenotype [Identifier] in Serum or Plasma by Immunofixation
Short Name: A1AT Phenotyp SerPl IFE
Display Name: Alpha 1 antitrypsin phenotype Immunofixation
Consumer Name Alpha Get Info: Alpha 1 antitrypsin phenotype, Blood

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 1.0h(2)
Last Updated: Version 2.73 (MIN)
Change Reason: Release 2.71: COMPONENT: Changed for naming consistency across LOINC.;
Order vs. Observation: Both
Common Test Rank Get Info: 3161

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Alpha-1-Antitrypsin-Phänotypisierung:Nachweis oder Identität:Zeitpunkt:Serum oder Plasma:Nominal:Immunfixation
el-GR	Greek (Greece)	Φαινότυπος Α1-αντιθρυψίνης:Prid:Pt:Ορός/Πλάσμα:Nom:Ανοσοκαθήλωση Synonyms: Prid Α1-αντιθρυψίνη Φαινότυπος Α1-αντιθρυψίνης
es-AR	Spanish (Argentina)	fenotipificación de alfa 1 antitripsina:presencia o identidad:punto en el tiempo:suero/plasma:Nominal:inmunofijación
es-ES	Spanish (Spain)	Fenotipo Alfa 1 antitripsina:Presencia o identidad:Punto temporal:Suero o Plasma:Nom:Inmunofijación
es-MX	Spanish (Mexico)	Fenotipado de alfa 1 antitripsina:Presencia o identidad:Punto temporal:Suero o Plasma:Nominal:Inmunofijación
fr-CA	French (Canada)	Phénotype de l'alpha 1 antitrypsine:Présence ou identité:Temps ponctuel:Sérum/Plasma:Nominal:Immunofixation
fr-FR	French (France)	Alpha-1-antitrypsine phénotype:Identification:Ponctuel:Sérum/Plasma:Résultat nominal:Immunofixation
fr-BE	French (Belgium)	Phénotypage de l'alpha-1-antitrypsine:Présence ou identité:Temps ponctuel:Sérum/Plasma:Nominal:Immunofixation Synonyms: AAT
it-IT	Italian (Italy)	Alfa 1 antitripsina, fenotipo:Prid:Pt:Siero/Plasma:Nom:Immunofissazione Synonyms: Chimica Fenotipo dell''alfa 1 antitripsina Plasma Presenza o Identità Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR	Korean (Korea, Republic Of)	알파 1-항트립신 표현형:존재:검사시점:혈청/혈장:명칭결과:면역고정
nl-NL	Dutch (Netherlands)	alfa-1-antitrypsine fenotype:identificator:moment:serum of plasma:nominaal:immunofixatie
pt-BR	Portuguese (Brazil)	Alfa 1 antitripsina Fenotipagem:Ident:Pt:Sor/Plas:Nom:Imunofixação Synonyms: ; A1AT Phenotyp; A1A; Alpha-1-protease inhibitor; Alpha-1-proteinase inhibitor; A-1-AT; AAT; Alpha-1-trypsin inhibitor; Alpha-1-antitrypsin.total; Identity or presence; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Nominal; IFE; Ifix; Immunofixation electrophoresis; Phenotypic; Pheno; A1; Alfa; I; Chemistry
ru-RU	Russian (Russian Federation)	Альфа 1 антитрипсин фенотипирование:ПрИд:ТчкВрм:Сыв/Плаз:Ном:Иммунофиксация Synonyms: Номинальный;Именной Плазма Присутствие или Идентификация Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	Alfa 1 antitripsin fenotipleme:MevcKimlik:Zmlı:Ser/Plaz:Snf:İmmünfiksasyon
zh-CN	Chinese (China)	Alpha 1 抗胰蛋白酶表现型:存在与否或特征标识:时间点:血清/血浆:名义型:免疫固定电泳分析法 Synonyms: Ⅰ A1 型 A1A;A1AT;A-1-AT;AAT;Alpha 1 抗胰蛋白酶.总计;Alpha 1 胰蛋白酶抑制剂;Alpha 1 蛋白酶抑制剂;Alpha1 抗胰蛋白酶;Alpha1 抗胰蛋白酶.总计;Alpha1 胰蛋白酶抑制剂;Alpha1 蛋白酶抑制剂;Alpha-1-抗胰蛋白酶;Alpha1-抗胰蛋白酶;Alpha-1-抗胰蛋白酶.总计;Alpha1-抗胰蛋白酶.总计;Alpha-1-胰蛋白酶抑制剂;Alpha1-胰蛋白酶抑制剂;Alpha-1-蛋白酶抑制剂;Alpha1-蛋白酶抑制剂;α1 抗胰蛋白酶 Alpha 1 抗胰蛋白酶（α1-抗胰蛋白酶、A1AT）表现型（表现型分型、表型分型、表现型分析、表型分析、表现型鉴定、表型鉴定） I IFE;Ifix;免疫固定法;免疫固定电泳（Immunofixation electrophoresis，IFE）;免疫固定电泳法 α α1 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类存在;存在与否;特征标识;身份;身份标识时刻;随机;随意;瞬间血清或血浆阿尔法

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