LOINC
Version 2.67

69002-4Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detectionActive

Term Description

This term was created for (but not limited to) Gen-Probe's Aptima HPV assay (Cat No. 302610) that detects the E6 and E7 polycistronic mRNA from 14 high-risk HPV genotypes (16,18,31,33,35,39,45,51,52,56,58,59,66,and 68) that can lead to cervical cancer. E6/E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. This test is similar to LOINC 69358-0, which measures cells containing E6+E7 mRNA via flow cytometry.
Source: Regenstrief LOINC

Part Description

LP135722-9   Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Most human papilloma virus (HPV) genomes encode for eight major proteins, six "early" (E1, E2, E3, E4, E6, and E7) and two "late" (L1 and L2). The "early" are regulatory in function. E6 and E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. Source: Regenstrief LOINC

Fully-Specified Name

Component
Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Property
PrThr
Time
Pt
System
Cvx
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
HPV E6+E7 mRNA Cvx Ql NAA+probe
Display Name
HPV E6+E7 mRNA NAA+probe Ql (Cvx)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.38
Last Updated
Version 2.63
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Panels

LOINC Long Common Name
86636-8 Family planning report - FPAR 2.0 set
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets
79544-3 HEDIS 2016 Value Sets
82955-6 HEDIS 2017 Value Sets
87625-0 HEDIS 2018 Value Sets
90766-7 HEDIS 2019 Value Sets
94137-7 HEDIS 2020 Value Sets

Language Variants Get Info

zh-CNChinese (CHINA)
人乳头瘤病毒 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 型 mRNA:存在情况或阈值:时间点:子宫颈:序数型:探针法.基因扩增.靶向
nl-NLDutch (NETHERLANDS)
Humaan papillomavirus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:aanwezigheid:moment:cervix:ordinaal:moleculaire techniek (PCR)
fr-FRFrench (FRANCE)
Papillomavirus humain 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 ARNm:Présence/Seuil:Ponctuel:Col de l'utérus:Qualitatif:PCR amplification de cible
it-ITItalian (ITALY)
Papilloma virus umano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:PrThr:Pt:Cvx:Ord:Sonda.amp.tar
ru-RURussian (RUSSIAN FEDERATION)
Вирус папилломы человека 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 мРНК:PrThr:ТчкВрм:Шейка:Пор:Проба.усил.миш
es-ESSpanish (SPAIN)
ARN m de Papilomavirus humano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7:PrThr:Punto temporal:Cuello uterino:Ord:Sonda con amplificación dirigida
tr-TRTurkish (TURKEY)
Human papilloma virüsü 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:MevcEşik:Zmlı:Cvx:Srl:Prob.amf.hdf

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=69002-4