69358-0
HPV E6+E7 mRNA cells/cells [Presence] in Cervix by Flow cytometry (FC)
Active
Term Description
This term was created for an assay that identifies cervical cells containing HPV E6 and E7 polycistronic mRNA using in situ hybridization with oligonucleotides specific for the mRNA transcripts. The cells remain intact, and following fixation and permeabilization, the probes enter the cells. The flow cytometer measures two things: 1. Quantification of E6 and E7 mRNA in each cell and 2. The percentage of cells over-expressing E6 and E7 mRNA. The test does not report the percentage quantity but an ordinal (positive, negative, indeterminant) based on the reported percentage. This test is similar to LOINC 69002-4, which is a target amplification nucleic acid probe test to detect E6+E7 mRNA.
Source: Regenstrief LOINC
Part Description
LP136531-3 Cells.HPV E6+E7 mRNA
Most human papilloma virus (HPV) genomes encode for eight major proteins, six "early" (E1, E2, E3, E4, E6, and E7) and two "late" (L1 and L2). The "early" are regulatory in function. E6 and E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Cells.HPV E6+E7 mRNA/cells
- Property
- PrThr
- Time
- Pt
- System
- Cvx
- Scale
- Ord
- Method
- Flow cytometry
Additional Names
- Short Name
- HPV E6+E7 mRNA cells/cells Cvx Ql FC
- Display Name
- HPV E6+E7 mRNA cells/cells FC Ql (Cvx)
- Consumer Name Alpha Get Info
- HPV E6+E7 MRNA Cells/cells, Cervix
Example Answer List: LL360-9
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.38
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 10844
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Células.HPV E6+E7 ARNm/células: |
es-MX | Spanish (Mexico) | Células ARNm de HPV E6 + E7 / células: |
fr-FR | French (France) | Cellules HPV E6+E7 ARNm /cellules: |
it-IT | Italian (Italy) | Cellule.HPV E6+E7 mRNA/cellule: Synonyms: Cellule HPV E6+E7 mRNA Cervice uterina Citometria a flusso (FC) Microbiologia Presenza o Soglia Punto nel tempo (episodio) |
nl-NL | Dutch (Netherlands) | cellen.HPV E6+E7 mRNA/cellen: Synonyms: baarmoederhals |
pl-PL | Polish (Poland) | Komórki.HPV E6+E7 mRNA/komórki: Synonyms: Komórki HPV E6+E7 mRNA Komórki.HPV E6+E7 mRNA/Komórki. |
ru-RU | Russian (Russian Federation) | Клетки.ВПЧ E6+E7 mRNA/клетки: Synonyms: Порядковый Точка во времени; |
tr-TR | Turkish (Turkey) | Hücreler.HPV E6+E7 mRNA/Hücreler: Synonyms: Akış hücremetresi Mevcut |
zh-CN | Chinese (China) | 细胞.人乳头状瘤病毒 E6+E7 mRNA/细胞: Synonyms: HPV E6+E7 mRNA细胞; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=69358-0
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright