7007-8

Dirithromycin [Susceptibility] by Gradient strip

Active

Part Descriptions

LP17270-7   Dirithromycin
Dirithromycin is a macrolide glycopeptide antibiotic.

Dirithromycin (Dynabac) is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-(2-methoxyethoxy)acetaldehyde. The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine. Erythromycyclamine is a semisynthetic derivative of erythromycin in which the 9-ketogroup of the erythronolide ring has been converted to an amino group. Erythromycyclamine retains the antibacterial properties of erythromycin oral administration. The prodrug, dirithromycin, is provided as enteric coated tablets to protect it from acid catalyzed hydrolysis in the stomach. Orally administered dirithromycin is absorbed rapidly into the plasma, largely from the small intestine. Spontaneous hydrolysis to erythromycyclamine occurs in the plasma. Oral bioavailability is estimated to be about 10%, but food does not affect absorption of the prodrug. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP6300-0   Gradient strip
A gradient strip is a reagent strip that contains a predefined concentration gradient of a specific antibiotic or combination of antibiotics that is used for antimicrobial susceptibility testing (AST) and antimicrobial resistance detection (ARD).
For AST, the result is reported in terms of the minimum inhibitory concentration (MIC) of a specific antimicrobial that prevents the visible growth of bacteria. In LOINC, the "Gradient strip" method is used for AST gradient strips that result in an MIC result.
For ARD, the result is reported as the presence or absence of a specific enzyme or other mechanism that confers resistance, which is determined based on comparing the inhibitory concentration (IC) of a specific antimicrobial with the IC of that antimicrobial plus a resistance inhibitor. In LOINC, the "Gradient strip ARD" method is used for ARD gradient strips, which are not intended for determining individual MIC values. Source: Regenstrief LOINC

Fully-Specified Name

Component

Dirithromycin

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

Gradient strip

Additional Names

Short Name

Dirithromycin Islt Grad strip

Display Name

Dirithromycin Strip [Susc]

Consumer Name Alpha Get Info

Susceptibility to Dirithromycin

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 1.0h(2)

Last Updated

Version 2.56

Change Reason

Feb 2016-removed "E-test" from the short and long names because the "ETEST" name is trademarked

Order vs. Observation

Observation

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Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• Dynabac
• Epsilometer
• Estrip
• E-strip
• Grad strip
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• MIC
• Minimum inhibitory concentration
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty

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LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.