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Part Description

LP145733-4   Amyloid beta 40 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.

The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.

Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
Amyloid beta 40 peptide:MCnc:Pt:CSF:Qn:
Long Common Name
Amyloid beta 40 peptide [Mass/volume] in Cerebrospinal Fluid
Short Name
AL beta40 CSF-mCnc
Display Name
Amyloid beta 40 peptide (CSF) [Mass/Vol]
Consumer Name Alpha Get Info
Amyloid beta 40 peptide, Spinal fluid

Part Model Get Info

  • Component
    Amyloid beta 40 peptide
    LP145733-4
    • Analyte
      Amyloid beta 40 peptide
      LP145733-4
      • Component Numerator
        Amyloid beta 40 peptide
        LP145733-4
        • Component Numerator Core
          Amyloid beta 40 peptide
          LP145733-4
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MCnc
    LP6827-2
  • Time
    Pt
    LP6960-1
  • System
    CSF
    LP7156-5
    • System Core
      CSF
      LP7156-5
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.83 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
18066

Member of these Panels

LOINCLong Common Name
98492-2Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebrospinal Fluid
106057-3Beta-Amyloid 1-42 and 1-40 panel - Cerebrospinal Fluid

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Amyloid-beta 40 peptid:Hmotnostní koncentrace:Časový bod:Mozkomíšní mok:Kvantitativní:
de-ATGerman (Austria)Synonyms: Amyloid Beta 40 Peptid /L
de-DEGerman (Germany)Amyloid-beta-40-Peptid:Massenkonzentration:Zeitpunkt:Liquor:Quantitativ:
Synonyms: Zerebrospinalflüssigkeit
el-GRGreek (Greece)β-αμυλοειδές πεπτίδιο 40:MCnc:Pt:ΕΝΥ:Qn:
Synonyms: CHEM MCnc Pt Qn β-αμυλοειδές πεπτίδιο 40 ΕΝΥ
es-ESSpanish (Spain)Péptido amiloide beta 40:Concentración de masa:Punto temporal:Líquido Cefalorraquideo:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Péptido beta 40 amiloide:Concentración de masa:Punto temporal:Fluído espinal cerebral:Cuantitativo:
fr-FRFrench (France)Peptide bêta amyloïde 1-40:Masse/Volume:Ponctuel:Liquide céphalorachidien:Numérique:
it-ITItalian (Italy)Amiloide beta 40 peptide:MCnc:Pt:LCS:Qn:
Synonyms: Chimica Concentrazione di Massa Liquido cerebrospinale Punto nel tempo (episodio)
nl-NLDutch (Netherlands)amyloïd-bèta-40-peptide:massa/volume:moment:liquor cerebrospinalis:kwantitatief:
Synonyms: amyloid beta 40 peptide
pl-PLPolish (Poland)Amyloid beta 40 peptyd:stężenie masowe:punkt w czasie:płyn mózgowo-rdzeniowy:ilościowy:
Synonyms: Peptyd amyloidu beta 40
ru-RURussian (Russian Federation)Амилоид бета 40 пептид:МассКонц:ТчкВрм:ЦСЖ:Колич:
Synonyms: Количественный Массовая концентрация Точка во времени;Момент Цереброспинальная жидкость
tr-TRTurkish (Turkey)Amiloid beta 40 peptid:KütlKons:Zmlı:BOS:Kant:
zh-CNChinese (China)淀粉样蛋白 Beta 40 肽:质量浓度:时间点:脑脊液:定量型:
Synonyms: B CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 β β淀粉样蛋白;淀粉样β蛋白 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 淀粉样蛋白 淀粉状朊 淀粉状蛋白 Beta 40 肽;Ab40 peptide;Ab40 肽;Abeta 40;AL beta40;Alzheimer 氏病;Alzheimer 病;Alzheimer氏病;Alzheimer病;Beta 淀粉样肽;Beta-淀粉样肽;Beta-淀粉样蛋白;Beta-淀粉状朊;Beta-淀粉状蛋白;β淀粉样肽;β-淀粉样肽;β-淀粉样蛋白;β-淀粉状朊;β-淀粉状蛋白;淀粉样蛋白β40 肽;淀粉状朊 Beta 40 肽;淀粉状朊β40 肽;淀粉状蛋白β40 肽;老年性痴呆;老年痴呆;阿尔茨海默病 硫酸胶化纤维素 类淀粉物 缩氨酸 胶化纤维素 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 贝塔

Example Units

UnitSource
pg/mLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=70072-4