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Term Description

Cryoglobulins are proteins in the blood that are soluble at 37 degrees Celsius but precipitate at lower temperatures. There are three classes of cryoglobulins that are differentiated by what type of protein precipitates. In type 1, the proteins involved are monoclonal immunoglobulins, usually IgM. Type 2 proteins include a mixture of monoclonal IgM and polyclonal IgG proteins. Type 3 may include polyclonal IgM and IgG cryoglobulins. In some cases, the proteins congeal rather than precipitate when observed in the laboratory. An additional process of hypotonically diluting the serum may be required in these instances in order to observe precipitation. PMID: 3787096
Source: Regenstrief LOINC

Part Description

LP15516-5   Cryoglobulin
Serum cryoglobulins are immunoglobulins that, in vitro, precipitate at temperatures below 37°C and redissolve on rewarming.Cryoglobulins can be transient and without clinical implications or they can be a marker of significant disease. Monoclonal cryoglobulins, which are IgG, IgM, or IgA, or monoclonal free light chains, are usually associated with haematological disorders. Mixed cryoglobulins, which contain polyclonal immunoglobulins with or without a monoclonal component, are found in many infectious and systemic disorders. There is a significant association between essential mixed cryoglobulinaemia and hepatitis C virus infection (> 90%). PMID: 11825916 Source: Regenstrief LOINC, PMID: 11825916

LOINC Names Get Info

Fully-Specified Name
Cryoglobulin:PrThr:Pt:Ser:Ord:Hypotonic dilution
Long Common Name
Cryoglobulin [Presence] in Serum by Hypotonic dilution
Short Name
Cryoglob Ser Ql Hypotonic dilution
Display Name
Cryoglobulin Hypotonic dilution Ql (S)
Consumer Name Alpha Get Info
Cryoglobulin, Blood

Part Model Get Info

  • Component
    Cryoglobulin
    LP15516-5
    • Analyte
      Cryoglobulin
      LP15516-5
      • Component Numerator
        Cryoglobulin
        LP15516-5
        • Component Numerator Core
          Cryoglobulin
          LP15516-5
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Hypotonic dilution
    LP148652-3

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.56 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Kryoglobulin:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Hypotonické ředění
el-GRGreek (Greece)Κρυοσφαιρίνη:PrThr:Pt:Ορός:Ord:Υποτονική αραίωση
Synonyms: Ord PrThr Pt SERO Αραίωση Κρυοσφαιρίνη Ορός Υποτονική αραίωση
es-ESSpanish (Spain)Crioglobulina:PrThr:Punto temporal:Suero:Ord:Disolución hipotónica
es-MXSpanish (Mexico)Crioglobulina:Presencia o umbral:Punto temporal:Suero:Ordinal:Dilución hipotónica
fr-FRFrench (France)Cryoglobulines:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Dilution hypotonique
it-ITItalian (Italy)Crioglobulina:PrThr:Pt:Siero:Ord:Diluizione ipotonica
Synonyms: Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)cryoglobuline:aanwezigheid:moment:serum:ordinaal:hypotonische verdunning
tr-TRTurkish (Turkey)Kriyoglobulin:MevcEşik:Zmlı:Ser:Srl:Hipotonik dilüsyon
Synonyms: Mevcut
zh-CNChinese (China)冷球蛋白:存在情况或阈值:时间点:血清:序数型:低渗稀释
Synonyms: Cryo;冷凝蛋白质;冷沉淀;冷沉淀物;冷沉淀球蛋白;冷沉球蛋白 HYPO 低张 低张的 低渗 低渗压 低渗压的 低渗性（Hypotonic，HYPO） 低渗性的 低渗性稀释 低渗的 低渗透 低渗透的 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 稀释 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=70970-9