Version 2.80

Term Description

The presence of anti-Epstein-Barr Nuclear Antigen-1 (anti-EBNA-1) IgM and anti-EBNA-1 IgG antibodies in human serum/plasma can be simultaneously detected by rapid ELISA. Results are used to aid in the diagnosis of acute Infectious Mononucleosis (IM). The relative strength of IgG and IgM reactions is visually compared. When IgM is greater than or equal to IgG, it is indicative of acute/current mononucleosis infection and the test is reported as "positive." When IgG response is greater than IgM, it is indicative of previous exposure and the test is reported as "negative." Absence of both IgG and IgM is also "negative" and indicates no previous exposure to EBV. This code is based on, but not limited to, Merdian BioScience's MONOLERT Rapid ELISA Test for infectious Mononucleosis.

Part Description

LP128550-3   Epstein Barr virus nuclear 1
Epstein-Barr virus (EBV) is a gamma herpes virus also known as human herpes 4 and occurs only in humans. EBV is prevalent worldwide with over 90% of the adult population infected in their lifetime. The virus is spread mainly through body fluids and particularly through saliva. Symptoms of infection include fatigue, fever, inflamed throat, swollen lymph nodes in the neck, enlarged spleen, swollen liver and rash. EBV becomes dormant post infection but occasionally will reactivate especially in immunosuppressed patients. Laboratory tests are used to determine whether the infection is a primary infection (absence of anti-EBNA, presence of anti-VCA) or a past infection (presence of both anti-EBNA and anti-VCA) Epstein-Barr nuclear antigen begins to appear 2-4 months after symptoms first are evident and persist for the life of the patient. (http://www.cdc.gov/epstein-barr/laboratory-testing.html) Epstein-Barr nuclear antigen 1 (EBNA1) antibody is the main antibody tested in immunoassay tests. It is also the only EBV protein regularly present in EBV-associate neoplasms. There is little difference between EBNA 1 and EBNA 2 other than in their prevalence across the globe. Viral capsid antigen (VCA) p150 antibody is most commonly used in laboratory testing, but VCA p18 is also utilized though some reports of mixed results has been observed.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component
Epstein Barr virus nuclear 1 Ab.IgG & IgM
Property
ColorRto
Time
Pt
System
Ser/Plas
Scale
Nom
Method
IA.rapid

Additional Names

Long Common Name
Epstein Barr virus nuclear 1 IgG and IgM [Color Ratio] in Serum or Plasma by Rapid immunoassay
Short Name
EBV NA 1 IgG+IgM SerPl IA.rapid-ColRto
Display Name
EBV nuclear 1 IgG and IgM IA.rapid Nom
Consumer Name Alpha Get Info
Epstein Barr virus (EBV) Nuclear 1 IgG and IgM antibodies, Blood

Example Answer List: LL2174-2

Source: Meridian Biosciences
Answer Code Score Answer ID
Color of IgM > or = IgG: Positive, acute/current mononucleosis LA18915-1
Color of IgG > IgM: Negative, previous exposure LA18916-9
Faint or no color for IgG and IgM: Negative, no previous exposure, patient is susceptible to EBV LA18917-7

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.56 (MIN)
Change Reason
The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Ιός Epstein Barr πυρηνικός 1 Αντισώματα IgG & IgM:ColorRto:Pt:Ορός/Πλάσμα:Nom:IA.rapid
Synonyms: ColorRto Ανοσοσφαιρίνη G Ανοσοσφαιρίνη M Ιός Ιός Epstein Barr Ιός Epstein Barr πυρηνικός 1 Πυρηνικό Πυρηνικός ιός Epstein Barr
es-ES Spanish (Spain) Virus nuclear de Epstein Barr Acs.IgG & IgM:ColorRto:Punto temporal:Suero o Plasma:Nom:IA.rapid
es-MX Spanish (Mexico) Virus de Epstein Barr nuclear 1 Ab IgG e IgM:Proporción de color:Punto temporal:Suero o Plasma:Nominal:Inmunoensayo rápido
fr-CA French (Canada) Nucléaire de l'Epstein-Barr 1, IgG & IgM:Ratio de couleur:Temps ponctuel:Sérum/Plasma:Nominal:IA.rapide
fr-FR French (France) Epstein barr virus 1 nucléaire Ac IgG et IgM:Comparaison couleur:Ponctuel:Sérum/Plasma:Résultat nominal:Immunoanalyse rapide
it-IT Italian (Italy) Epstein Barr virus, nucleari 1 Ab.IgG & IgM:Rapporto colore:Pt:Siero/Plasma:Nom:IA.rapido
Synonyms: Ab.IgG e IgM nucleari 1 del virus di Epstein Barr anticorpi IgG anticorpi IgG e IgM Anticorpi IgG+IgM anticorpo Immunoassay Immunoassay rapido Microbiologia Nucleari 1 del virus di Epstein Barr Nucleari del virus di Epstein Barr Plasma Punto nel tempo (episodio) Rapporto del colore Siero Siero o Plasma Virus di Epstein Barr
nl-NL Dutch (Netherlands) Epstein-Barr-virus nucleair 1 As.IgG & IgM:kleurverhouding:moment:serum of plasma:nominaal:immunoassay.sneltest
Synonyms: antistof; antilichaam IA IA.rapid
pl-PL Polish (Poland) Wirus Epsteina Barr antygen jądrowy 1 Ab.IgG i IgM:stosunek barw:punkt w czasie:surowica lub osocze:cecha:szybka metoda immunologiczna
Synonyms: Antygen jądrowy 1 wirusa Epsteina-Barr Antygen jądrowy wirusa Epsteina-Barr IgG IgM Przeciwciała IgG do antygenu jądrowego 1 wirusa Epsteina-Barr Przeciwciała IgG i IgM do antygenu jądrowego 1 wirusa Epsteina-Barr Wirus Epsteina-Barr
pt-BR Portuguese (Brazil) Epstein Barr vírus nuclear 1 Ac.IgG e IgM::Pt:Soro/Plas:Nom:Imunoensaio.rápido
ru-RU Russian (Russian Federation) Эпштейн Барр вирус ядерный 1 Ат.IgG & IgM:ЦветОтн:ТчкВрм:Сыв/Плаз:Ном:IA.rapid
Synonyms: Антитело Номинальный;Именной Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент Цвет отношение
tr-TR Turkish (Turkey) Epstein Barr virus nükleer 1 Ab.IgG & IgM:RenkOrn:Zmlı:Ser/Plaz:Snf:İA.hızlı
Synonyms: Çekirdek İmmünölçüm, immünoassay Rnk oranı
zh-CN Chinese (China) Epstein Barr 病毒细胞核 1 抗体.IgG 与 IgM:颜色比率:时间点:血清/血浆:名义型:免疫测定法.快速
Synonyms: Ⅰ Ab.IgG;IgG;抗体 IgG Ab.IgG+IgM;IgG+IgM;抗体 IgG+抗体 IgM Ab;自身抗体 Burkitt 淋巴瘤;EB 病毒;EBV;人类疱疹病毒 4 型;人类疱疹病毒 IV 型;人类疱疹病毒第四型;传染性单核细胞增多症;胃癌;鼻咽癌;爱波斯坦-巴尔病毒;埃波斯坦-巴尔病毒;E.B.病毒;埃-巴二氏病毒;疱疹病毒;传染性单核细胞增多症;癌症 EB 病毒细胞核 1;EBNA 1;EBV NA 1;EBV 细胞核 1;人类疱疹病毒 4 型细胞核 1;人类疱疹病毒 IV 型细胞核 1 EB 病毒细胞核;EBNA;EBV NA;EBV 细胞核;人类疱疹病毒 4 型细胞核;人类疱疹病毒 IV 型细胞核 I 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 G 免疫球蛋白 M 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 快速免疫测定;快速免疫测定法;快速免疫分析法;快速免疫检定法;快速免疫检定;快速免疫试验;酶免疫测定法.快速;快速酶免疫测定法;快速酶免疫测定;快速酶免疫分析法;快速酶免疫检定法;快速酶免疫检定;快速酶免疫试验 抗体.IgG & IgM;抗体.IgG+IgM 时刻;随机;随意;瞬间 显色比率;颜色比值;颜色比;显色比值 核;胞核 核心抗体IgG 核心抗原抗体.IgG 核心抗原抗体IgG 核抗体.IgG 核抗体IgG 核抗原抗体.IgG 核抗原抗体IgG 爱波斯坦 爱泼斯坦 血清或血浆

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