Version 2.78

Term Description

A pericentric inversion of chromosome 16, inv(16)(p13;q22), results in a fused transcript between MYH11 (16p13.1) and CBFB (16q22.1) genes and is known to cause acute myeloid leukemia (AML). Techniques like real-time PCR are used to detect the MYH11-CBFB fused transcript. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.
Source: Regenstrief LOINC

Part Description

LP146062-7   inv(16)(p13.1;q22.1)(MYH11,CBFB)
The inv(16)(p13.1;q22.1) CBFB-MYH11 fusion transcript is a chromosomal abnormality associated with acute myelomonocytic leukemia (AML). This results in the formation of a chimeric protein between core binding factor beta and smooth muscle myosin heavy chain 11. Positive results are indicative of AML subtype M4E0. Source: Regenstrief LOINC

Fully-Specified Name

Component
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript
Property
NRto
Time
Pt
System
Bld/Tiss
Scale
Qn
Method
Molgen

Additional Names

Long Common Name
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Short Name
inv(16)(p13;q22)/control Bld/T
Display Name
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Consumer Name Alpha Get Info
inv(16)(p13.1;q22.1)(MYH11,CBFB)/control Transcript, Blood or tissue specimen

Basic Attributes

Class
MOLPATH.INV
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
5676

Member of these Panels

LOINC Long Common Name
72104-3 Acute and chronic leukemia fusion transcript per control transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) inv(16)(p13.1;q22.1)(MYH11,CBFB) Tránscritos de fusión/transcrito control:Relación de número:Punto temporal:Sangre o tejido:Qn:Genética molecular
Synonyms: Cuantitativo
es-MX Spanish (Mexico) inv (16) (p13.1; q22.1) (MYH11, CBFB) transcripción de fusión / transcripción de control:Proporción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-FR French (France) inv(16)(p13.1;q22.1)(MYH11,CBFB) transcrit de fusion/transcrit de référence:Nombre/Nombre:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
fr-CA French (Canada) inv(16)(p13.1;q22.1)(MYH11,CBFB) transcrit de fusion/Transcrit de contrôle:Ratio de numérique:Temps ponctuel:Sang/Tissu:Quantitatif:Molgen
it-IT Italian (Italy) inv(16)(p13.1;q22.1)(MYH11,CBFB), trascritto di fusione/trascritto di controllo:NRto:Pt:Sangue/Tess:Qn:Molgen
Synonyms: Genetica molecolare Inversione genetica Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) inv(16)(p13.1;q22.1)(MYH11,CBFB) fusietranscript/controle transcript:aantalsverhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek
Synonyms: molgen
pt-BR Portuguese (Brazil) inv(16)(p13.1;q22.1)(MYH11,CBFB) transcrição de fusão/controle de transcrição::Pt:Sg/Tecido:Qn:Genética molecular
ru-RU Russian (Russian Federation) inv(16)(p13.1;q22.1)(MYH11,CBFB) слияния транскрипт/контрольный транскрипт:КолОтн:ТчкВрм:Кр/Тк:Колич:МолГен
Synonyms: Количественное отношение Количественный Кровь Кровь или Ткань Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TR Turkish (Turkey) inv(16)(p13.1;q22.1)(MYH11,CBFB) füzyon transkript/kontrol transkripti:SayOr:Zmlı:Kan/Dk:Kant:Molgen
zh-CN Chinese (China) inv(16)(p13.1;q22.1)(MYH11,CBFB) 融合转录物/对照转录物:计数型比率:时间点:全血/组织:定量型:分子遗传学类实验室方法
Synonyms: 倒位(16)(p13.1;q22.1)(MYH11,CBFB);基因倒位;基因倒置;倒位;倒置;gene inversion 全血或组织;血液/组织;血液或组织 分子病理学.基因倒位;分子病理学试验.基因倒位;分子病理学试验类.倒位 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率 对照转录物（转录本、转录产物、转录子、转录）;对照基因转录本;控制转录本 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录 血;血液

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72210-8