72264-5
Bilirubin excess and oxyhemoglobin and methemoglobin and xanthochromia and albumin quotient panel - Serum and CSF
Active
1756-6 Albumin in CSF/Albumin in Serum or Plasma
Term Description
The albumin quotient (AQ; CSF albumin/serum or plasma albumin x 100) is an important measurement to quantify the blood-brain barrier function. Normal function of the AQ barrier depends on the age of the patient; in newborns, a higher permeability may be observed.
Source: Regenstrief LOINC
Part Descriptions
LP157103-5 Albumin.CSF/Albumin.SerPl
The albumin quotient (AQ; CSF albumin/serum albumin x 100) is an important measurement to quantify the blood-brain barrier function. Normal function of the CSF/serum barrier depends on the age of the patient; in newborns, a higher permeability may be observed.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Albumin.CSF/Albumin.SerPl
- Property
- RelRto
- Time
- Pt
- System
- Ser/Plas+CSF
- Scale
- Qn
- Method
Additional Names
- Short Name
- Alb CSF/SerPl
- Display Name
- Albumin in CSF/Albumin in Serum or Plasma (S/P+CSF) [Relative ratio]
- Consumer Name Alpha Get Info
- Albumin in CSF/Albumin in Serum Or Plasma, S/P+CSF
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.73
- Change Reason
- Added specimen of serum to existing term since the albumin quotient (AQ) of csf/serum is comparable to AQ of csf/plasma.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 2790
Formula (Readable)
([CSF albumin]/[serum or plasma albumin]) x 100
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72264-5 | Bilirubin excess and oxyhemoglobin and methemoglobin and xanthochromia and albumin quotient panel - Serum and CSF |
| 55121-8 | Multiple sclerosis panel - Serum and CSF |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Albumin.Liquor/Albumin.Serum oder Plasma: Synonyms: Zerebrospinalflüssigkeit |
| de-AT | German (Austria) | Synonyms: Albumin L/S-Quotient |
| es-ES | Spanish (Spain) | Albúmina en Líquido Cefalorraquideo/Albúmina.Suero-Plasma: Synonyms: Cuantitativo |
| es-AR | Spanish (Argentina) | albúmina en líquido cefalorraquídeo/albúmina plasmática: |
| es-MX | Spanish (Mexico) | Albúmina.CSF / Albúmina.SerPl: |
| fr-FR | French (France) | Albumine LCR/ Sérum/plasma: |
| fr-BE | French (Belgium) | Albumine.LCR/Albumine.sérum/plasma: |
| fr-CA | French (Canada) | Albumine.LCR/Albumine.sérum/plasma: Synonyms: Null |
| it-IT | Italian (Italy) | Albumina.CSF/Albumina.SieroPlasma: Synonyms: Albumina in CSF Albumina in Siero o Plasma Chimica Liquido cerebrospinale Plasma Punto nel tempo (episodio) Rapporto Relativo Siero Siero o Plasma Siero o Plasma e LCS |
| ko-KR | Korean (Korea, Republic Of) | 뇌척수액 알부민/혈장 알부민: |
| nl-NL | Dutch (Netherlands) | albumine.liquor cerebrospinalis/albumine.serum of plasma: |
| pl-PL | Polish (Poland) | Albumina w PMR/albumina w surowicy lub osoczu: |
| pt-BR | Portuguese (Brazil) | Albumina LCR/Albumina plasma: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Альбумин.ЦСЖ/Альбумин.СывПлаз: Synonyms: Альбумин в сыворотке или плазме Альбумин в ЦСЖ; |
| tr-TR | Turkish (Turkey) | Albumin.BOS/Albumin.SerPlaz: |
| zh-CN | Chinese (China) | 白蛋白.脑脊液/白蛋白.血清/血浆: Synonyms: Alb; |
Example Units
| Unit | Source |
|---|---|
| {ratio} | Example UCUM Units |
72261-1 Bilirubin excess [Moles/volume] in Serum and CSF
Term Description
The bilirubin excess is the most sophisticated parameter to exclude subarachnoidal hemorrhage in patient with negative cranial CT scan (Apperloo J.J., et al. CCLM FESCC (44), 2006).
Source: Regenstrief LOINC
Part Descriptions
LP157150-6 Bilirubin excess
Normally bilirubin is thought to enter CSF only by passing through the blood brain barrier bound to albumin. This allows us to predict an "expected" CSF bilirubin concentration. Since bilirubin is a breakdown product of oxyhemoglobin, the bilirubin excess in CSF can be used to predict subarachnoid hemorrhage in the absence of cranial CT findings. Billirubin excess is defined as the surplus CSF bilirubin concentration measured after subtraction of an estimated upper limit for the individual patient. This upper limit, called the ''CSF bilirubin limit'' (CBL), is a calculated by multiplying the serum bilirubin concentration times the albumin quotient: ([bilirubin]serum X [albumin]CSF/[albumin]serum) X 1.25." (Clin Chem Lab Med 2006;44(8):938-948)
Source: Regenstrief LOINC, PMID: 16879058
Observation Required in Panel
Required
Fully-Specified Name
- Component
- Bilirubin excess
- Property
- SCnc
- Time
- Pt
- System
- Ser+CSF
- Scale
- Qn
- Method
Additional Names
- Short Name
- Bilirubin excess Ser+CSF-sCnc
- Display Name
- Bilirubin excess (S+CSF) [Moles/Vol]
- Consumer Name Alpha Get Info
- Bilirubin excess, Serum+Cerebrospinal fluid
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.42
- Last Updated
- Version 2.42
- Order vs. Observation
- Observation
Formula (Readable)
Bilirubin Excess = Measured CSF Bilirubin - (1.25 X ([bilirubin]serum X [albumin]CSF/[albumin]serum))
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72264-5 | Bilirubin excess and oxyhemoglobin and methemoglobin and xanthochromia and albumin quotient panel - Serum and CSF |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Exceso de bilirrubina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Exceso de bilirrubina: |
| fr-FR | French (France) | Bilirubine excès: |
| it-IT | Italian (Italy) | Bilirubina, eccesso: Synonyms: Chimica Concentrazione di Sostanza Liquido cerebrospinale Punto nel tempo (episodio) Siero Siero & |
| nl-NL | Dutch (Netherlands) | bilirubine excess: |
| pl-PL | Polish (Poland) | Nadmiar bilirubiny: |
| pt-BR | Portuguese (Brazil) | Excesso de Bilirrubina: |
| ru-RU | Russian (Russian Federation) | Билирубина избыток: Synonyms: Количественный Молярность; |
| tr-TR | Turkish (Turkey) | Bilirubin yüksek: |
| zh-CN | Chinese (China) | 胆红素过多: Synonyms: CSF CSF; |
Example Units
| Unit | Source |
|---|---|
| umol/L | Example UCUM Units |
72262-9 Methemoglobin [Moles/volume] in Cerebral spinal fluid
Term Description
The bilirubin excess is the most sophisticated parameter to exclude subarachnoidal hemorrhage in patient with negative cranial CT scan. The conclusion is also dependent on the amount of presence of methemoglobin in CSF (Apperloo J.J., et al. CCLM FESCC (44), 2006)
Source: Regenstrief LOINC
Part Descriptions
LP15729-4 Methemoglobin
Methemoglobin is a form of the oxygen-carrying protein hemoglobin, in which the iron in the heme group is in the Fe3+ state, not the Fe2+ of normal hemoglobin. Metheomglobin appears blue and is unable to carry oxygen. The NADH-dependent enzyme methemoglobin reductase (AKA diaphorase I) is responsible for converting methemoglobin back to hemoglobin. Normally 1-2% of people's hemoglobin is methemoglobin, a higher percentage than this can be genetic or caused by exposure to various chemicals and depending on the level can cause health problems. A higher level of methemoglobin will tend to cause a pulse oximeter to read closer to 85% regardless of the true level of oxygen saturation. Methemoglobinemia can be caused by genetic abnormalities such as diaphorase I deficiency, or abnormal hemoglobin variants. It can also be caused by certain oxidizing drugs (benzocaine), antibiotics (trimethoprim or sulfanamides), analine dyes, metoclopramide, chlorates, bromates, and nitrates. Infants under 6 months are particularly susceptible when exposed to nitrates, benzocaine, or even dehydration. Methemoglobinemia can be treated with supplemental oxygen and methylene blue.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Methemoglobin (Wikipedia)
Observation Required in Panel
Required
Fully-Specified Name
- Component
- Methemoglobin
- Property
- SCnc
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
Additional Names
- Short Name
- MetHgb CSF-sCnc
- Display Name
- Methemoglobin (CSF) [Moles/Vol]
- Consumer Name Alpha Get Info
- Methemoglobin, Spinal fluid
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.42
- Last Updated
- Version 2.42
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72264-5 | Bilirubin excess and oxyhemoglobin and methemoglobin and xanthochromia and albumin quotient panel - Serum and CSF |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Metahemoglobina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Metahemoglobina: |
| et-EE | Estonian (Estonia) | Methemoglobiin: Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Liikvor |
| fr-FR | French (France) | Méthémoglobine: |
| fr-BE | French (Belgium) | Méthémoglobine: |
| fr-CA | French (Canada) | Méthémoglobine: |
| it-IT | Italian (Italy) | Metaemoglobina: Synonyms: Chimica Concentrazione di Sostanza Liquido cerebrospinale Metemoglobina Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | methemoglobine: |
| pl-PL | Polish (Poland) | Methemoglobina: Synonyms: Methemoglobina |
| pt-BR | Portuguese (Brazil) | Metahemoglobina: |
| ru-RU | Russian (Russian Federation) | Метгемогломин: Synonyms: Количественный Молярность; |
| tr-TR | Turkish (Turkey) | Methemoglobin: |
| zh-CN | Chinese (China) | 高铁血红蛋白: Synonyms: CSF CSF; |
Example Units
| Unit | Source |
|---|---|
| mmol/L | Example UCUM Units |
72263-7 Oxyhemoglobin [Moles/volume] in Cerebral spinal fluid
Term Description
The bilirubin-excess is the most sophisticated parameter to exclude subarachnoidal hemorrhage in patient with negative cranial CT scan. The conclusion is also dependent on the amount of oxyhemoglobin present in CSF. (Apperloo J.J., et al. CCLM FESCC (44), 2006)
Source: Regenstrief LOINC
Part Descriptions
LP15766-6 Oxyhemoglobin
Oxyhemoglobin is the oxygen-loaded form of hemoglobin, the transport molecule for oxygen in the blood. Each hemoglobin molecule is a tetramer with 4 sites that reversibly bind oxygen. Loading occurs in the lung where the pO2 is high, and unloading occurs in tissues according to the hemoglobin saturation curve. The fraction of hemoglobin sites loaded with an oxygen molecule is close to 100% in arterial blood and 60-80% in mixed venous blood. Changes in absorption spectra of hemoglobin upon binding oxygen is the basis for pulse oximetry, and partly account for its bright red color compared to the purple blue of deoxyhemoglobin due to a higher absorption spectrum (940 nm vs. 660 nm wavelength for oxyhemoglobin).
Source: Regenstrief LOINC
Observation Required in Panel
Required
Fully-Specified Name
- Component
- Oxyhemoglobin
- Property
- SCnc
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
Additional Names
- Short Name
- OxyHgb CSF-sCnc
- Display Name
- Oxyhemoglobin (CSF) [Moles/Vol]
- Consumer Name Alpha Get Info
- Oxyhemoglobin, Spinal fluid
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.42
- Last Updated
- Version 2.42
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72264-5 | Bilirubin excess and oxyhemoglobin and methemoglobin and xanthochromia and albumin quotient panel - Serum and CSF |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Oxihemoglobina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Oxihemoglobina: |
| et-EE | Estonian (Estonia) | Oksühemoglobiin: Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Liikvor |
| fr-FR | French (France) | Oxyhémoglobine: |
| fr-BE | French (Belgium) | Oxyhémoglobine: |
| fr-CA | French (Canada) | Oxyhémoglobine: |
| it-IT | Italian (Italy) | Ossiemoglobina: Synonyms: Chimica Concentrazione di Sostanza Liquido cerebrospinale Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | oxyhemoglobine: |
| pl-PL | Polish (Poland) | Oksyhemoglobina: |
| pt-BR | Portuguese (Brazil) | Oxihemoglobina: |
| ru-RU | Russian (Russian Federation) | Оксигемоглобин: Synonyms: Количественный Молярность; |
| tr-TR | Turkish (Turkey) | Oksihemoglobin: |
| zh-CN | Chinese (China) | 氧合血红蛋白: Synonyms: CSF CSF; |
Example Units
| Unit | Source |
|---|---|
| mmol/L | Example UCUM Units |
13532-7 Xanthochromia [Presence] of Cerebral spinal fluid Qualitative
Part Descriptions
LP18043-7 Xanthochromia
Xanthochromia refers to the yellowish appearance of cerebrospinal fluid in certain medical conditions, especially subarachnoid hemorrhage, when red blood cells (RBC) enter the CSF during bleeding. RBCs are eventually destroyed, releasing the oxygen-carrying molecule heme, which in turn is degraded to yield bilirubin, a yellow-green pigment. Heme that enters the CSF for different reasons (for example when a small blood vessel is damaged during a lumbar puncture), has no time to be digested and bilirubin is not generated. Many laboratories rely on the color of the fluid alone when testing for xanthochromia. Recent guidelines, however, suggest that spectrophotometry should be performed since bilirubin absorbs light of wavelengths between 450-460 nm. Two related substances, oxyhemoglobin and methemoglobin (410-418 nm and 403-410 nm absorption ranges, respectively) that are also released when heme is metabolized may be detected during this process. There are other causes for xanthochromia.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
Observation Required in Panel
Optional
Fully-Specified Name
- Component
- Xanthochromia
- Property
- PrThr
- Time
- Pt
- System
- CSF
- Scale
- Ord
- Method
Additional Names
- Short Name
- Xanthochromia CSF Ql
- Display Name
- Xanthochromia Ql (CSF)
- Consumer Name Alpha Get Info
- Xanthochromia, Spinal fluid
Basic Attributes
- Class
- SPEC
- Type
- Laboratory
- First Released
- Version 1.0k
- Last Updated
- Version 2.73
- Change Reason
- Release 2.67: ORDER_OBS: Updated the ORDER_OBS value from "Order" to "Both".; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 1064
Example Answer List LL3596-5
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Detected | LA11882-0 | ||
| Not detected | LA11883-8 | ||
| Inconclusive Copyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value) | LA9663-1 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72264-5 | Bilirubin excess and oxyhemoglobin and methemoglobin and xanthochromia and albumin quotient panel - Serum and CSF |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Xantocromía: |
| es-MX | Spanish (Mexico) | Xantocromía: |
| es-AR | Spanish (Argentina) | xantocromía: |
| et-EE | Estonian (Estonia) | Ksantokroomia: Synonyms: Järgarvuline Juhuslik Liikvor |
| fr-FR | French (France) | Xanthochromie: |
| fr-BE | French (Belgium) | Xanthochromie: |
| fr-CA | French (Canada) | Xanthochromie: |
| it-IT | Italian (Italy) | Xantocromia: Synonyms: Caratteristiche campione Liquido cerebrospinale Presenza o Soglia Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | xanthochromie: |
| pt-BR | Portuguese (Brazil) | Xantocromia: Synonyms: Xanthchromia; |
| ru-RU | Russian (Russian Federation) | Ксантохромия: Synonyms: Порядковый Точка во времени; |
| tr-TR | Turkish (Turkey) | Ksantokromi: Synonyms: Mevcut |
| zh-CN | Chinese (China) | 皮肤黄染: Synonyms: CSF CSF; |
Third Party Copyright
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